{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:01:44Z","timestamp":1777089704485,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EPISTOP","award":["602391"],"award-info":[{"award-number":["602391"]}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013142","name":"TSC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013142","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Tuberous Sclerosis Assosiation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Complex cortical malformations (CCMs), such as hemimegalencephaly and polymicrogyria, are associated with drug-resistant epilepsy and developmental impairment. They share certain neuropathological characteristics including mammalian target of rapamycin (mTOR) activation and an atypical number of white matter neurons. To get a better understanding of the pathobiology of the lesion architecture, we investigated the role of neurite outgrowth inhibitor A (NogoA), a known regulator of neuronal migration. Epilepsy surgery specimens from 16 CCM patients were analyzed and compared with sections of focal cortical dysplasia IIB (FCD IIB, n\u2009=\u200922), tuberous sclerosis complex (TSC, n\u2009=\u20098) as well as healthy controls (n\u2009=\u200915). Immunohistochemistry was used to characterize NogoA, myelination, and mTOR signaling. Digital slides were evaluated automatically with ImageJ. NogoA staining showed a significantly higher expression within the white matter of CCM and FCD IIB, whereas cortical tubers presented levels similar to controls. Further analysis of possible associations of NogoA with other factors revealed a positive correlation with mTOR and seizure frequency. To identify the main expressing NogoA cell type, double staining revealed dysmorphic neuronal white matter cells. Increased NogoA expression is associated with profound inhibition of neuritic sprouting and therefore contributes to a decrease in neuronal network complexity in CCM patients.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa159","type":"journal-article","created":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T15:55:01Z","timestamp":1612108501000},"page":"274-282","source":"Crossref","is-referenced-by-count":1,"title":["Neurite Outgrowth Inhibitor (NogoA) Is Upregulated in White Matter Lesions of Complex Cortical Malformations"],"prefix":"10.1093","volume":"80","author":[{"given":"Theresa","family":"Scholl","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics and Adolescent Medicine, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria-Elisabeth","family":"Gruber","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics and Adolescent Medicine, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Samueli","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics and Adolescent Medicine, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Lehner","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Kasprian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Czech","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy J","family":"Reinten","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Amsterdam UMC, University of Amsterdam , Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"Hoogendijk","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Amsterdam UMC, University of Amsterdam , Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A","family":"Hainfellner","sequence":"additional","affiliation":[{"name":"Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Amsterdam UMC, University of Amsterdam , Amsterdam, The Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) , Zwolle, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"M\u00fchlebner","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Amsterdam UMC, University of Amsterdam , Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Feucht","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics and Adolescent Medicine, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,31]]},"reference":[{"key":"2024032523381566900_nlaa159-B1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/brain\/aws019","article-title":"A developmental and genetic classification for malformations of cortical development: Update 2012","volume":"135","author":"Barkovich","year":"2012","journal-title":"Brain"},{"key":"2024032523381566900_nlaa159-B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/nan.12462","article-title":"Review: The international consensus classification of Focal Cortical Dysplasia\u2014A critical update 2018","volume":"44","author":"Najm","year":"2018","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2024032523381566900_nlaa159-B3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00234-009-0644-2","article-title":"Current concepts of polymicrogyria","volume":"52","author":"Barkovich","year":"2010","journal-title":"Neuroradiology"},{"key":"2024032523381566900_nlaa159-B4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/088307380201700512","article-title":"Hemimegalencephaly: Part 1. Genetic, clinical, and imaging aspects","volume":"17","author":"Flores-Sarnat","year":"2002","journal-title":"J Child Neurol"},{"key":"2024032523381566900_nlaa159-B5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/epi.13264","article-title":"Surgical management of medically refractory epilepsy in patients with polymicrogyria","volume":"57","author":"Wang","year":"2016","journal-title":"Epilepsia"},{"key":"2024032523381566900_nlaa159-B6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/dmcn.12390","article-title":"Hemimegalencephaly: What happens when children get older?","volume":"56","author":"Wu","year":"2014","journal-title":"Dev Med Child Neurol"},{"key":"2024032523381566900_nlaa159-B7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ebcr.2017.02.002","article-title":"Evolution of epilepsy in hemimegalencephaly from infancy to adulthood: Case report and review of the literature","volume":"7","author":"Ikeda","year":"2017","journal-title":"Epilepsy Behav Case Rep"},{"key":"2024032523381566900_nlaa159-B8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1148\/rg.243035135","article-title":"Best cases from the AFIP: Hemimegalencephaly","volume":"24","author":"Broumandi","year":"2004","journal-title":"Radiographics"},{"key":"2024032523381566900_nlaa159-B9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1750-3639.2012.00581.x","article-title":"Malformations of cortical development","volume":"22","author":"Aronica","year":"2012","journal-title":"Brain Pathol"},{"key":"2024032523381566900_nlaa159-B10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awh681","article-title":"Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly","volume":"129","author":"Salamon","year":"2006","journal-title":"Brain"},{"key":"2024032523381566900_nlaa159-B11","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/brain\/awq078","article-title":"Clinical and imaging heterogeneity of polymicrogyria: A study of 328 patients","volume":"133","author":"Leventer","year":"2010","journal-title":"Brain"},{"key":"2024032523381566900_nlaa159-B12","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/brain\/awh658","article-title":"Periventricular nodular heterotopia with overlying polymicrogyria","volume":"128","author":"Wieck","year":"2005","journal-title":"Brain"},{"key":"2024032523381566900_nlaa159-B13","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.clinph.2009.06.022","article-title":"Combined SEEG and source localisation study of temporal lobe schizencephaly and polymicrogyria","volume":"120","author":"Maillard","year":"2009","journal-title":"Clin Neurophysiol"},{"key":"2024032523381566900_nlaa159-B14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1528-1167.2012.03667.x","article-title":"Intracranial evaluation of the epileptogenic zone in regional infrasylvian polymicrogyria","volume":"54","author":"Ramantani","year":"2013","journal-title":"Epilepsia"},{"key":"2024032523381566900_nlaa159-B15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/dmcn.12840","article-title":"The histopathology of polymicrogyria: A series of 71 brain autopsy studies","volume":"58","author":"Jansen","year":"2016","journal-title":"Dev Med Child Neurol"},{"key":"2024032523381566900_nlaa159-B16","volume-title":"GeneReviews(R)","author":"Stutterd","year":"1993"},{"key":"2024032523381566900_nlaa159-B17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/BF01236058","article-title":"Unlayered polymicrogyria: Structural and developmental aspects","volume":"184","author":"Ferrer","year":"1991","journal-title":"Anat Embryol"},{"key":"2024032523381566900_nlaa159-B18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00401-010-0663-4","article-title":"Hemimegalencephaly: A fetal case with neuropathological confirmation and review of the literature","volume":"120","author":"Manoranjan","year":"2010","journal-title":"Acta Neuropathol"},{"key":"2024032523381566900_nlaa159-B19","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1212\/01.wnl.0000183747.05269.2d","article-title":"A developmental and genetic classification for malformations of cortical development","volume":"65","author":"Barkovich","year":"2005","journal-title":"Neurology"},{"key":"2024032523381566900_nlaa159-B20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pediatrneurol.2013.11.005","article-title":"Congenital cytomegalovirus infection and brain clefting","volume":"50","author":"White","year":"2014","journal-title":"Pediatr Neurol"},{"key":"2024032523381566900_nlaa159-B21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00381-018-4019-z","article-title":"Congenital pial AVF along the falx cerebri with complete agenesis of the corpus callosum and bilateral parasagittal pachygyria-polymicrogyria secondary to chronic ischemia","volume":"35","author":"Ngam","year":"2019","journal-title":"Childs Nerv Syst"},{"key":"2024032523381566900_nlaa159-B22","volume-title":"GeneReviews(R)","author":"Mirzaa","year":"1993"},{"key":"2024032523381566900_nlaa159-B23","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1093\/brain\/awx203","article-title":"Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly","volume":"140","author":"Alcantara","year":"2017","journal-title":"Brain"},{"key":"2024032523381566900_nlaa159-B24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ana.20616","article-title":"Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes","volume":"58","author":"Piao","year":"2005","journal-title":"Ann Neurol"},{"key":"2024032523381566900_nlaa159-B25","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/brain\/awv045","article-title":"PI3K\/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia","volume":"138","author":"Jansen","year":"2015","journal-title":"Brain"},{"key":"2024032523381566900_nlaa159-B26","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1523\/JNEUROSCI.22-09-03553.2002","article-title":"Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions","volume":"22","author":"Huber","year":"2002","journal-title":"J Neurosci"},{"key":"2024032523381566900_nlaa159-B27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/01.jnen.0000248559.83573.71","article-title":"Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions","volume":"66","author":"Kuhlmann","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523381566900_nlaa159-B28","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/epi.12143","article-title":"A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II","volume":"54","author":"Shepherd","year":"2013","journal-title":"Epilepsia"},{"key":"2024032523381566900_nlaa159-B29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00441-012-1432-6","article-title":"The role of Nogo-A in axonal plasticity, regrowth and repair","volume":"349","author":"Pernet","year":"2012","journal-title":"Cell Tissue Res"},{"key":"2024032523381566900_nlaa159-B30","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nn1261","article-title":"The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination","volume":"7","author":"Karnezis","year":"2004","journal-title":"Nat Neurosci"},{"key":"2024032523381566900_nlaa159-B31","doi-asserted-by":"crossref","first-page":"e97803","DOI":"10.1371\/journal.pone.0097803","article-title":"Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: A randomized, first-in-human clinical trial","volume":"9","author":"Meininger","year":"2014","journal-title":"PLoS One"},{"key":"2024032523381566900_nlaa159-B32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jnen\/64.2.129","article-title":"Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis","volume":"64","author":"Satoh","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523381566900_nlaa159-B33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1460-9568.2004.03470.x","article-title":"Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy","volume":"20","author":"Bandtlow","year":"2004","journal-title":"Eur J Neurosci"},{"key":"2024032523381566900_nlaa159-B34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/NEN.0b013e31825d6585","article-title":"Expression of the Nogo-A system in cortical lesions of pediatric patients with tuberous sclerosis complex and focal cortical dysplasia type IIb","volume":"71","author":"Yu","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523381566900_nlaa159-B35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2024032523381566900_nlaa159-B36","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/bpa.12452","article-title":"Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex","volume":"27","author":"Scholl","year":"2017","journal-title":"Brain Pathol"},{"key":"2024032523381566900_nlaa159-B37","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.nbd.2006.07.018","article-title":"Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph\/mceph mouse","volume":"24","author":"Lavebratt","year":"2006","journal-title":"Neurobiol Dis"},{"key":"2024032523381566900_nlaa159-B38","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbrc.2016.03.037","article-title":"Upregulated expression of Nogo-A and NgR in an experimental model of focal microgyria regulates the migration, proliferation and self-renewal of subventricular zone neural progenitors","volume":"473","author":"Yu","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2024032523381566900_nlaa159-B39","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.bbadis.2017.04.008","article-title":"Nogo-A in the visual system development and in ocular diseases","volume":"1863","author":"Pernet","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2024032523381566900_nlaa159-B40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1385\/MN:34:3:205","article-title":"The growing role of mTOR in neuronal development and plasticity","volume":"34","author":"Jaworski","year":"2006","journal-title":"Mol Neurobiol"},{"key":"2024032523381566900_nlaa159-B41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-6-30","article-title":"Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1","volume":"6","author":"Murthy","year":"2013","journal-title":"Mol Brain"},{"key":"2024032523381566900_nlaa159-B42","doi-asserted-by":"crossref","first-page":"e86820","DOI":"10.1371\/journal.pone.0086820","article-title":"Protein synthesis dependence of growth cone collapse induced by different Nogo-A-domains","volume":"9","author":"Manns","year":"2014","journal-title":"PLoS One"},{"key":"2024032523381566900_nlaa159-B43","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1471-4159.2011.07520.x","article-title":"Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons","volume":"119","author":"Peng","year":"2011","journal-title":"J Neurochem"},{"key":"2024032523381566900_nlaa159-B44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnmol.2018.00042","article-title":"A Nogo-like signaling perspective from birth to adulthood and in old age: Brain expression patterns of ligands, receptors and modulators","volume":"11","author":"Smedfors","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"2024032523381566900_nlaa159-B45","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1523\/JNEUROSCI.5586-07.2008","article-title":"Synaptic function for the Nogo-66 receptor NgR1: Regulation of dendritic spine morphology and activity-dependent synaptic strength","volume":"28","author":"Lee","year":"2008","journal-title":"J Neurosci"},{"key":"2024032523381566900_nlaa159-B46","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/cercor\/bhl146","article-title":"Involvement of the myelin-associated inhibitor Nogo-A in early cortical development and neuronal maturation","volume":"17","author":"Mingorance-Le Meur","year":"2007","journal-title":"Cereb Cortex"},{"key":"2024032523381566900_nlaa159-B47","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1093\/cercor\/bhp307","article-title":"Nogo-A regulates neural precursor migration in the embryonic mouse cortex","volume":"20","author":"Mathis","year":"2010","journal-title":"Cereb Cortex"},{"key":"2024032523381566900_nlaa159-B48","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/hmg\/ddl062","article-title":"Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice","volume":"15","author":"Kappeler","year":"2006","journal-title":"Hum Mol Genet"},{"key":"2024032523381566900_nlaa159-B49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S1474-4422(16)30399-4","article-title":"Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: A randomised, double-blind, placebo-controlled, phase 2 trial","volume":"16","author":"Meininger","year":"2017","journal-title":"Lancet Neurol"},{"key":"2024032523381566900_nlaa159-B50","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/STROKEAHA.107.507426","article-title":"Nogo-A expression after focal ischemic stroke in the adult rat","volume":"39","author":"Cheatwood","year":"2008","journal-title":"Stroke"},{"key":"2024032523381566900_nlaa159-B51","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nm1436","article-title":"Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates","volume":"12","author":"Freund","year":"2006","journal-title":"Nat Med"},{"key":"2024032523381566900_nlaa159-B52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2024032523381566900_nlaa159-B53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuroscience.2014.12.035","article-title":"Loss of Nogo-A-expressing neurons in a rat model of Parkinson's disease","volume":"288","author":"Schawkat","year":"2015","journal-title":"Neuroscience"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/80\/3\/274\/36335384\/nlaa159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/80\/3\/274\/36335384\/nlaa159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:01:39Z","timestamp":1711411299000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/80\/3\/274\/6124781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,31]]},"published-print":{"date-parts":[[2021,2,22]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlaa159","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2021,1,31]]}}}