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Symptoms range in severity but are generally milder and later in onset than in Alzheimer disease (AD). Recently, an early predilection for neurofibrillary degeneration in the hippocampal CA2 subregion has been demonstrated in PART, whereas AD neuropathologic change (ADNC) typically displays relative sparing of CA2 until later stages. In this study, we utilized a semiquantitative scoring system to evaluate asymmetry of neurofibrillary degeneration between left and right hippocampi in 67 PART cases and 17 ADNC cases. 49% of PART cases demonstrated asymmetric findings in at least one hippocampal subregion, and 79% of the asymmetric cases displayed some degree of CA2 asymmetry. Additionally, 19% of cases revealed a difference in Braak score between the right and left hippocampi. There was a significant difference in CA2 neurofibrillary degeneration (p\u2009=\u20090.0006) and CA2\/CA1 ratio (p\u2009&amp;lt;\u20090.0001) when comparing the contralateral sides, but neither right nor left was more consistently affected. These data show the importance of analyzing bilateral hippocampi in the diagnostic evaluation of PART and potentially of other neurodegenerative diseases.<\/jats:p>","DOI":"10.1093\/jnen\/nlab032","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T03:00:39Z","timestamp":1618628439000},"page":"436-445","source":"Crossref","is-referenced-by-count":35,"title":["Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease"],"prefix":"10.1093","volume":"80","author":[{"given":"Jamie M","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Upstate Medical University From the , Syracuse, New York, USA"},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center , San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Fudym","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of New York, Upstate Medical University , Syracuse, New York, USA"},{"name":"Department of Pathology, University of Michigan , Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"School of Medicine, University of Michigan , Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F","family":"Bieniek","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Upstate Medical University From the , Syracuse, New York, USA"},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center , San Antonio, Texas, USA"},{"name":"Department of Neuroscience, Mayo Clinic , Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center , San Antonio, Texas, USA"},{"name":"Department of Neurology, University of Texas Health Science Center , San Antonio, Texas, USA"},{"name":"The Framingham Heart Study , Framingham, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles L","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center , Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Crary","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Upstate Medical University From the , Syracuse, New York, USA"},{"name":"Department of Pathology, State University of New York, Upstate Medical University , Syracuse, New York, USA"},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center , San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"2024032523395014900_nlab032-B1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/BF00296494","article-title":"Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: A rare subtype in 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