{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:04:27Z","timestamp":1790355867393,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AG028383"],"award-info":[{"award-number":["P30 AG028383"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG057187"],"award-info":[{"award-number":["R01 AG057187"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG042475"],"award-info":[{"award-number":["R01 AG042475"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG054060"],"award-info":[{"award-number":["R01 AG054060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 NS118584"],"award-info":[{"award-number":["RF1 NS118584"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) often occur in aged brains that also contain appreciable Alzheimer disease neuropathologic changes (ADNC). Question has arisen as to whether LATE-NC can occur independently of ADNC. We evaluated data from the University of Kentucky Alzheimer\u2019s Disease Research Center autopsy cohort (383 included subjects) to address 2 questions: (i) Is LATE-NC seen in the absence of ADNC, outside of persons who had the frontotemporal dementia (FTD) clinical syndrome? and (ii) is LATE-NC associated with cognitive impairment across the full spectrum of ADNC severity? In the present study, the pathologic combination of LATE-NC (Stage &amp;gt;1) and low\/no ADNC was common: 8.9% (34\/383) of all subjects (including demented and non-demented individuals) showed this combination. There were no FTLD-TDP cases to be included from the community-based cohort. Across a broad range of ADNC severity, the presence of LATE-NC was associated with impaired cognition but was never associated with a FTD clinical syndrome.<\/jats:p>","DOI":"10.1093\/jnen\/nlab050","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T14:07:54Z","timestamp":1626444474000},"page":"649-651","source":"Crossref","is-referenced-by-count":33,"title":["LATE Neuropathologic Changes with Little or No Alzheimer Disease is Common and is Associated with Cognitive Impairment but Not Frontotemporal Dementia"],"prefix":"10.1093","volume":"80","author":[{"given":"Peter T","family":"Nelson","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"2024032523403913800_nlab050-B1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"2024032523403913800_nlab050-B2","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/brain\/awz224","article-title":"LATE to the PART-y","volume":"142","author":"Josephs","year":"2019","journal-title":"Brain"},{"key":"2024032523403913800_nlab050-B3","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1093\/brain\/awz226","article-title":"Reply: LATE to the 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