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We previously demonstrated that hp-tau-dependent p-\u03b1Syn accumulation was associated with the activation of GSK-3\u03b2 in the brains of P301L tau transgenic mice. To confirm the effects of another mutant tau on p-\u03b1Syn accumulation in vivo, we herein examined the brains of PS19 mice that overexpress human P301S mutant tau. Immunohistochemically, hp-tau and p-\u03b1Syn aggregates were detected in the same neuronal cells in the cerebrum and brain stem of aged PS19 mice. A semiquantitative analysis showed a positive correlation between hp-tau and p-\u03b1Syn accumulation. Furthermore, an activated form of GSK-3\u03b2 was detected within cells containing both hp-tau and p-\u03b1Syn aggregates in PS19 mice. Western blotting showed a decrease in inactivated PP2A levels in PS19 mice. The present results suggest that the overexpression of human P301S mutant tau induces p-\u03b1Syn accumulation that is accompanied by not only GSK-3\u03b2, but also PP2A activation in PS19 mice, and highlight the synergic effects between tau and \u03b1Syn in the pathophysiology of neurodegenerative diseases that show the codeposition of tau and \u03b1Syn.<\/jats:p>","DOI":"10.1093\/jnen\/nlab054","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T11:39:16Z","timestamp":1624275556000},"page":"731-740","source":"Crossref","is-referenced-by-count":8,"title":["Deposition of Phosphorylated \u03b1-Synuclein and Activation of GSK-3\u03b2 and PP2A in the PS19 Mouse Model of Tauopathy"],"prefix":"10.1093","volume":"80","author":[{"given":"Yuta","family":"Takaichi","sequence":"first","affiliation":[{"name":"From the Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo , 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