{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:06:18Z","timestamp":1788977178287,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004486","name":"Fondazione Cassa di Risparmio di Perugia","doi-asserted-by":"publisher","award":["2015.0377.021"],"award-info":[{"award-number":["2015.0377.021"]}],"id":[{"id":"10.13039\/501100004486","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MicroRNAs (miRNAs) are small non-coding RNAs that play key roles in tumorigenesis as modulators of cell signaling pathways. miRNA expression has been found to be dysregulated in several human and canine tumors, but data are not yet available on canine meningioma. In this study, we analyzed the expression of 12 miRNAs (i.e. miR-335, miR-200a, miR-98, miR-96, miR-190a, miR-29c, miR-219-5p, miR-155, miR-146a, miR-145, miR-136, miR-451) by RT-qPCR in a series of 41 formalin-fixed, paraffin-embedded canine meningiomas, and normal arachnoid samples. We identified 8 dysregulated miRNAs that might be involved in canine meningioma pathogenesis. Five miRNAs (i.e. miR-96, miR-145, miR-335, miR-200a, miR-29c), were downregulated in tumor samples and 3 (i.e. miR-136, miR-155, miR-146a) were upregulated. Moreover, miR-200a was overexpressed in grade III compared to grade I and grade II meningiomas, suggesting that it might have a dual role in tumor initiation and progression. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses suggest that dysregulated miRNAs might influence cellular processes and pathways mainly involved in tumor cell migration, extracellular matrix interactions, cell proliferation, and inflammatory responses. The characterization of miRNA functions in canine meningiomas is needed to assess their potential clinical utility, also in view of the relevance of the dog as a potential spontaneous animal model of human disease.<\/jats:p>","DOI":"10.1093\/jnen\/nlab057","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T12:39:37Z","timestamp":1626525577000},"page":"769-775","source":"Crossref","is-referenced-by-count":7,"title":["MicroRNA Dysregulation in Canine Meningioma: RT-qPCR Analysis of Formalin-Fixed Paraffin-Embedded Samples"],"prefix":"10.1093","volume":"80","author":[{"given":"Greta","family":"Foiani","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia From the , Perugia, Italy (GF, GG, MTM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Guelfi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia From the , Perugia, Italy (GF, GG, MTM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Mandara","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia From the , Perugia, Italy (GF, GG, MTM)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"2024032523404451300_nlab057-B1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/jvim.12136","article-title":"Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight","volume":"27","author":"Song","year":"2013","journal-title":"J Vet Intern Med"},{"key":"2024032523404451300_nlab057-B2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1939-1676.2008.0106.x","article-title":"Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogs","volume":"22","author":"Petersen","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2024032523404451300_nlab057-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/neuonc\/noz150","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012-2016","volume":"21","author":"Ostrom","year":"2019","journal-title":"Neuro Oncol"},{"key":"2024032523404451300_nlab057-B4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00005072-198603000-00001","article-title":"Presidential address: the histopathology of meningiomas. 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