{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:41:27Z","timestamp":1772502087088,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To improve the therapy of neonatal central nervous system infections, well-characterized animal models are urgently needed. The present study analyzes neuropathological alterations with particular focus on neural injury and repair in brains of neonatal mice with Listeria monocytogenes (LM) meningitis\/meningoencephalitis using a novel nasal infection model. The hippocampal formation and frontal cortex of 14 neonatal mice with LM meningitis\/meningoencephalitis and 14 uninfected controls were analyzed by histology, immunohistochemistry, and in situ tailing for morphological alterations. In the dentate gyrus of the hippocampal formation of mice with LM meningitis\/meningoencephalitis, an increased density of apoptotic neurons visualized by in situ tailing (p\u2009=\u20090.04) and in situ tailing plus immunohistochemistry for activated Caspase-3 (p\u2009&amp;lt;\u20090.0001) was found. A decreased density of dividing cells stained with an anti-PCNA-antibody (p\u2009&amp;lt;\u20090.0001) and less neurogenesis visualized by anti-calretinin (p\u2009&amp;lt;\u20090.0001) and anti-calbindin (p\u2009=\u20090.01) antibodies were detected compared to uninfected controls. The density of microglia was higher in LM meningitis (p\u2009&amp;lt;\u20090.0001), while the density of astrocytes remained unchanged. Infiltrating monocytes and neutrophilic granulocytes likely contributed to tissue damage. In conclusion, in the brains of LM-infected mice a strong immune response was observed which led to neuronal apoptosis and an impaired neural regeneration. This model appears very suitable to study therapies against long-term sequelae of neonatal LM meningitis.<\/jats:p>","DOI":"10.1093\/jnen\/nlab079","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T21:43:46Z","timestamp":1630964626000},"page":"861-867","source":"Crossref","is-referenced-by-count":5,"title":["Neural Injury and Repair in a Novel Neonatal Mouse Model of <i>Listeria Monocytogenes<\/i> Meningoencephalitis"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-965X","authenticated-orcid":false,"given":"Jana","family":"Seele","sequence":"first","affiliation":[{"name":"Department of Neuropathology, University Medical Center G\u00f6ttingen, Georg-August-University G\u00f6ttingen, G\u00f6ttingen , Germany"},{"name":"Department of Geriatrics, Evangelisches Krankenhaus G\u00f6ttingen-Weende , G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Ball\u00fcer","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Medical Center G\u00f6ttingen, Georg-August-University G\u00f6ttingen, G\u00f6ttingen , Germany"},{"name":"Department of Geriatrics, Evangelisches Krankenhaus G\u00f6ttingen-Weende , G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone C","family":"Tauber","sequence":"additional","affiliation":[{"name":"Department of Neurology, RWTH University Hospital , Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Bunkowski","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Medical Center G\u00f6ttingen, Georg-August-University G\u00f6ttingen, G\u00f6ttingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Medical Center G\u00f6ttingen, Georg-August-University G\u00f6ttingen, G\u00f6ttingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Stadelmann","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Medical Center G\u00f6ttingen, Georg-August-University G\u00f6ttingen, G\u00f6ttingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Beineke","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Hannover , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"P\u00e4gelow","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epizootics, Centre of Infection Medicine, Freie Universit\u00e4t Berlin , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Fulde","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epizootics, Centre of Infection Medicine, Freie Universit\u00e4t Berlin , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Nau","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Medical Center G\u00f6ttingen, Georg-August-University G\u00f6ttingen, G\u00f6ttingen , Germany"},{"name":"Department of Geriatrics, Evangelisches Krankenhaus G\u00f6ttingen-Weende , G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"2024032523415854000_nlab079-B1","volume-title":"Neonatal Meningitis","author":"Bundy","year":"2020"},{"key":"2024032523415854000_nlab079-B2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clp.2014.10.004","article-title":"Bacterial meningitis in infants","volume":"42","author":"Ku","year":"2015","journal-title":"Clin Perinatol"},{"key":"2024032523415854000_nlab079-B3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/bmj.323.7312.533","article-title":"Meningitis in infancy in England and Wales: Follow up at age 5 years","volume":"323","author":"Bedford","year":"2001","journal-title":"BMJ"},{"key":"2024032523415854000_nlab079-B4","doi-asserted-by":"crossref","first-page":"F173","DOI":"10.1136\/fn.88.3.F173","article-title":"Neonatal meningitis","volume":"88","author":"Heath","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2024032523415854000_nlab079-B5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1056\/NEJM199710023371404","article-title":"Bacterial meningitis in the United States in 1995. 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