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Preclinical models have been developed to simulate the clinical paradigm to better understand the neuropathophysiology and develop therapeutic treatment. Neuropathological findings in the preclinical models have not been comprehensively examined before. This systematic review studies the past 40\u2009years of the histological findings after open surgical repair in preclinical models. Our main finding is that damage is predominantly in the grey matter of the spinal cord, although white matter damage in the spinal cord is also reported. Future research needs to examine the neuropathological findings in preclinical models after endovascular repair, a newer type of surgical repair used to treat aortic aneurysms.<\/jats:p>","DOI":"10.1093\/jnen\/nlab084","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T18:27:22Z","timestamp":1631903242000},"page":"895-911","source":"Crossref","is-referenced-by-count":10,"title":["Histological Findings After Aortic Cross-Clamping in Preclinical Animal Models"],"prefix":"10.1093","volume":"80","author":[{"given":"Hamdy","family":"Awad","sequence":"first","affiliation":[{"name":"From the Department of Anesthesiology, Wexner Medical Center, The Ohio State University , Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Efanov","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology, Wexner Medical Center, The Ohio State University , Columbus, Ohio, 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