{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:51:32Z","timestamp":1778575892967,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Shelanski Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Resected lesions from the pineal region are rare specimens encountered by surgical pathologists, and their heterogeneity can pose significant diagnostic challenges. Here, we reviewed 221 pineal region lesions resected at New York-Presbyterian Hospital\/Columbia University Irving Medical Center from 1994 to 2019 and found the most common entities to be pineal parenchymal tumors (25.3%), glial neoplasms (18.6%), and germ cell tumors (17.6%) in this predominantly adult cohort of patients. Six cases of a rare midline entity usually found exclusively in the fourth ventricle, the rosette-forming glioneuronal tumor, were identified. These tumors exhibit biphasic morphology, with a component resembling pilocytic astrocytoma admixed with variable numbers of small cells forming compact rosettes and perivascular pseudorosettes. Targeted sequencing revealed a 100% co-occurrence of novel and previously described genetic alterations in the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways, suggesting a synergistic role in tumor formation. The most common recurrent mutation, PIK3CA H1047R, was identified in tumor cells forming rosettes and perivascular pseudorosettes. A review of the literature revealed 16 additional cases of rosette-forming glioneuronal tumors in the pineal region. Although rare, this distinctive low-grade tumor warrants consideration in the differential diagnosis of pineal region lesions.<\/jats:p>","DOI":"10.1093\/jnen\/nlab089","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T07:58:13Z","timestamp":1631174293000},"page":"933-943","source":"Crossref","is-referenced-by-count":14,"title":["Rosette-Forming Glioneuronal Tumor in the Pineal Region: A Series of 6 Cases and Literature Review"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-4287","authenticated-orcid":false,"given":"Chun-Chieh","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center From the , New York, New York, USA"},{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center , Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh M","family":"Mansukhani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center From the , New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-0286","authenticated-orcid":false,"given":"Jeffrey N","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Columbia University Irving Medical Center , New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-0226","authenticated-orcid":false,"given":"Peter","family":"Canoll","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center From the , New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Zanazzi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center , Lebanon, New Hampshire, USA"},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center , Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2024032523420901100_nlab089-B1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuchi.2014.01.005","article-title":"Incidence of pineal tumours. A review of the literature","volume":"61","author":"Mottolese","year":"2015","journal-title":"Neurochirurgie"},{"key":"2024032523420901100_nlab089-B2","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neurol.2008.01.008","article-title":"Pathology of tumors of the pineal region","volume":"164","author":"De Girolami","year":"2008","journal-title":"Rev Neurol (Paris)"},{"key":"2024032523420901100_nlab089-B3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/00000478-200205000-00004","article-title":"A rosette-forming glioneuronal tumor of the fourth ventricle: Infratentorial form of dysembryoplastic neuroepithelial tumor?","volume":"26","author":"Komori","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"2024032523420901100_nlab089-B4","first-page":"vdaa116","article-title":"Rosette-forming glioneuronal tumor: An illustrative case and a systematic review","volume":"2","author":"Wilson","year":"2020","journal-title":"Neurooncol 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Report of thirty-nine cases","volume":"23","author":"Daumas-Duport","year":"1988","journal-title":"Neurosurg"},{"key":"2024032523420901100_nlab089-B20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00005072-197905000-00006","article-title":"Pineocytoma with astrocytomatous differentiation","volume":"38","author":"Borit","year":"1979","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523420901100_nlab089-B21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/brain\/102.2.289","article-title":"The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). 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