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We examined data from the National Alzheimer's Coordinating Center to compare clinical features of autopsy-confirmed LATE-NC and FTLD-TDP. A total of 265 LATE-NC and 92 FTLD-TDP participants were included. Cognitive and behavioral symptoms were compared, stratified by level of impairment based on global clinical dementia rating (CDR) score. LATE-NC participants were older at death, more likely to carry APOE \u03b54, more likely to have Alzheimer disease neuropathology, and had lower (i.e. less severe) final CDR global scores than those with FTLD-TDP. Participants with FTLD-TDP were more likely to present with primary progressive aphasia, or behavior problems such as apathy, disinhibition, and personality changes. Among participants with final CDR score of 2\u20133, those with LATE-NC were more likely to have visuospatial impairment, delusions, and\/or visual hallucinations. These differences were robust after sensitivity analyses excluding older (\u226580\u2009years at death), LATE-NC stage 3, or severe Alzheimer cases. Overall, FTLD-TDP was more globally severe, and affected younger participants, whereas psychoses were more common in LATE-NC.<\/jats:p>","DOI":"10.1093\/jnen\/nlab098","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T18:10:01Z","timestamp":1633111801000},"page":"1024-1032","source":"Crossref","is-referenced-by-count":21,"title":["Differences in Symptomatic Presentation and Cognitive Performance Among Participants With LATE-NC Compared to FTLD-TDP"],"prefix":"10.1093","volume":"80","author":[{"given":"Merilee A","family":"Teylan","sequence":"first","affiliation":[{"name":"National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington From the , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mock","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington From the , Seattle, 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