{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:10:08Z","timestamp":1788491408130,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860212"],"award-info":[{"award-number":["81860212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760256"],"award-info":[{"award-number":["81760256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960256"],"award-info":[{"award-number":["81960256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Provincial Natural Science Foundation for Youth Scientific Research","award":["20192ACBL21038"],"award-info":[{"award-number":["20192ACBL21038"]}]},{"name":"Jiangxi Provincial Natural Science Foundation for Youth Scientific Research","award":["20192BAB215021"],"award-info":[{"award-number":["20192BAB215021"]}]},{"name":"Youth Scientific Research Foundation of Jiangxi Education Department","award":["GJJ180144"],"award-info":[{"award-number":["GJJ180144"]}]},{"name":"Jiangxi Provincial Key R&D Program","award":["20202BBGL73039"],"award-info":[{"award-number":["20202BBGL73039"]}]},{"name":"Academic and Technical Leaders of Major Disciplines Foundation","award":["20204BCJL22049"],"award-info":[{"award-number":["20204BCJL22049"]}]},{"name":"Natural Science Foundation of Jiangxi","award":["20192BAB205038"],"award-info":[{"award-number":["20192BAB205038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The nuclear factor kappa B (NF-\u03baB) pathway and inhibitor of NF-\u03baB kinase \u03b2 (IKK\u03b2) are involved in Alzheimer disease (AD) pathogenesis. This study explored the mechanisms underlying IKK\u03b2-mediated A\u03b2 aggregation and neuron regeneration in APP.PS1 mice. Adenoviral transduction particles were injected into the hippocampal CA1 region of the mice to knock down or inhibit target genes. Morris water maze was performed to evaluate the cognitive function of the mice. A\u03b2 deposition was determined by histological examination. sh-IKK\u03b2 plasmids and microRNA (miR)-155-5p inhibitor were transfected into A\u03b21-42-induced N2a cells. The expressions of AD-related proteins were detected by Western blot. The interaction between S-phase kinase-associated protein 2 (SKP2) and IKK\u03b2 was assessed by co-immunoprecipitation. IKK\u03b2 knockdown (KD) and miR-155-5p inhibition ameliorated cognitive impairment, improved neuron regeneration, and attenuated A\u03b2 deposition in APP\/PS1 mice. SKP2 KD aggravated cognitive impairment, inhibited neuron regeneration, and promoted A\u03b2 deposition in the mice. SKP2 regulated the stability of IKK\u03b2 protein via ubiquitination. MiR-155-5p regulates A\u03b2 deposition and the expression of A\u03b2 generation-related proteins in N2a cells via targeting SKP2. These results indicate that the miR-155-5p\/SKP2\/IKK\u03b2 axis was critical for pathogenesis in this AD model and suggest the potential of miR-155-5p as a target for AD treatment.<\/jats:p>","DOI":"10.1093\/jnen\/nlab116","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T03:03:36Z","timestamp":1638673416000},"page":"16-26","source":"Crossref","is-referenced-by-count":16,"title":["MicroRNA-155-5p Targets SKP2, Activates IKK\u03b2, Increases A\u03b2 Aggregation, and Aggravates a Mouse Alzheimer Disease Model"],"prefix":"10.1093","volume":"81","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun-Hu","family":"Gu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Juan","family":"Cheng","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Tian","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liao","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-7795","authenticated-orcid":false,"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"2024032523432230700_nlab116-B1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","article-title":"Alzheimer\u2019s disease","volume":"167","author":"Soria Lopez","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"2024032523432230700_nlab116-B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s 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