{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:53:29Z","timestamp":1784400809599,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Uppsala University Hospital and Hans Gabriel and Alice Trolle-Wachtmeister Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The hallmark alteration in \u03b1-synucleinopathies, \u03b1-synuclein, is observed not only in the brain but also in the peripheral tissues, particularly in the intestine. This suggests that endoscopic biopsies performed for colon cancer screening could facilitate the assessment of \u03b1-synuclein in the gastrointestinal (GI) tract. Using immunohistochemistry for \u03b1-synuclein, we assessed whether GI biopsies could be used to confirm an ongoing \u03b1-synucleinopathy. Seventy-four subjects with cerebral \u03b1-synucleinopathy in various Braak stages with concomitant GI biopsies were available for study. In 81% of the subjects, \u03b1-synuclein was seen in the mucosal\/submucosal GI biopsies. Two subjects with severe cerebral \u03b1-synucleinopathy and a long delay between biopsy and death displayed no \u03b1-synuclein pathology in the gut, and 11 subjects with sparse cerebral \u03b1-synucleinopathy displayed GI \u03b1-synuclein up to 36\u2009years prior to death. The finding that there was no GI \u03b1-synuclein in 19% of the subjects with cerebral \u03b1-synucleinopathy, and \u03b1-synuclein was observed in the gut of 11 subjects (15%) with sparse cerebral \u03b1-synucleinopathy even many years prior to death is unexpected and jeopardizes the use of assessment of \u03b1-synuclein in the peripheral tissue for confirmation of an ongoing cerebral \u03b1-synucleinopathy.<\/jats:p>","DOI":"10.1093\/jnen\/nlac023","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T06:52:28Z","timestamp":1649314348000},"page":"356-362","source":"Crossref","is-referenced-by-count":5,"title":["Gastrointestinal Biopsy Obtained During Cancer Screening, a Biological Marker for \u03b1-Synucleinopathy?"],"prefix":"10.1093","volume":"81","author":[{"given":"Jelena","family":"Jotanovic","sequence":"first","affiliation":[{"name":"Department of Pathology, Uppsala University Hospital , Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Milin-Lazovic","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade , Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Alafuzoff","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uppsala University Hospital , Uppsala, Sweden"},{"name":"Department of Immunology, Genetics and Pathology, Uppsala University , Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"2024032523453683300_nlac023-B1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol"},{"key":"2024032523453683300_nlac023-B2","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"2024032523453683300_nlac023-B3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/mds.24996","article-title":"Identifying prodromal Parkinson\u2019s disease: Pre-motor disorders in Parkinson\u2019s disease","volume":"27","author":"Postuma","year":"2012","journal-title":"Mov Disord"},{"key":"2024032523453683300_nlac023-B4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/ene.12753","article-title":"Can we use peripheral tissue biopsies to diagnose Parkinson\u2019s disease? 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