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The basic morphological classification of plaques into neuritic, cored and diffuse has been supplemented by sophisticated immunohistochemical and biochemical analyses and increasingly detailed mapping of plaque brain distribution. Changes in plaque classification and staging have in turn contributed to changes in the definition and diagnostic criteria for AD. All of this information continues to be tested by clinicopathological correlations and it is through the insights thereby gained that we will best be able to employ the powerful tool of amyloid imaging.<\/jats:p>","DOI":"10.1093\/jnen\/nlac030","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T02:42:21Z","timestamp":1653100941000},"page":"387-413","source":"Crossref","is-referenced-by-count":33,"title":["A History of Senile Plaques: From Alzheimer to Amyloid Imaging"],"prefix":"10.1093","volume":"81","author":[{"given":"Thomas G","family":"Beach","sequence":"first","affiliation":[{"name":"From the Civin Laboratory for Neuropathology, Banner Sun Health Research Institute , Sun City, Arizona, 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