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OB A\u03b2 was found in less than 5% of cases in lower Thal phases 0 and 1, in 20% of cases in phase 2, in 60% of cases in phase 3 and in more than 80% of cases in higher Thal phases 4 and 5. OB A\u03b2 and tau pathology significantly predicted a Thal phase greater than 3, a Braak NF stage greater than 4, and an MMSE score lower than 24. While OB tau pathology is almost universal in the elderly and therefore is not a good predictor of AD severity, OB A\u03b2 pathology coincides with clinically-manifest AD and might prove to be a useful biomarker of the extent of brain spread of both amyloid and tau pathology.<\/jats:p>","DOI":"10.1093\/jnen\/nlac042","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T07:31:42Z","timestamp":1656142302000},"page":"643-649","source":"Crossref","is-referenced-by-count":16,"title":["Olfactory Bulb Amyloid-\u03b2 Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-7421","authenticated-orcid":false,"given":"C\u00e9cilia","family":"Tremblay","sequence":"first","affiliation":[{"name":"From the Department of Neuropathology, Banner Sun Health Research Institute , Sun City, Arizona, 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Neuropathology, Banner Sun Health Research Institute , Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A","family":"Shill","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute , Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Driver-Dunckley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona , Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamal H","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona , Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G","family":"Beach","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Banner Sun Health Research 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