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These odd astrocytes, now well known to neuropathologists, are present in a large variety of neurological disorders, and yet the mechanisms underlying their generation and their functional attributes are still not well understood. They undergo abnormal mitoses and fail to accomplish cytokinesis, resulting in multinucleation. Oxidative stress, hypoxia, and inflammation may be contributing pathologies to generate these astrocytes. The abnormal mitoses occur from changes in cell shape, the accumulation of cytoplasmic proteins, and the mislocalization of many of the important molecules whose coordination is necessary for proper mitotic spindle formation. Modern technologies will be able to characterize their abnormalities and solve century old questions of their form and function.<\/jats:p>","DOI":"10.1093\/jnen\/nlac043","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T14:15:23Z","timestamp":1654956923000},"page":"588-595","source":"Crossref","is-referenced-by-count":3,"title":["Alzheimer Type I Astrocytes: Still Mysterious Cells"],"prefix":"10.1093","volume":"81","author":[{"given":"James E","family":"Goldman","sequence":"first","affiliation":[{"name":"From the Division of Neuropathology, Department of Pathology & Cell Biology, Columbia University Vagelos College of Physicians and Surgeons and The Taub Institute for Research on Alzheimer's Disease and Aging, NY-Presbyterian Columbia University Irving Medical Center , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"2024032523462734000_nlac043-B1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jnen\/60.2.121","article-title":"Alzheimer-Type I astrogliopathy (AIA) and its implications for dynamic plasticity of astroglia: A historical review of the significance of AIA","volume":"60","author":"Ma","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523462734000_nlac043-B2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02866030","article-title":"Ein Beitrag zur Klinik und pathologischen Anatomie der Westphal-Str\u00fcmpellschen Pseudosklerose","volume":"8","author":"V. 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