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Hence, we are uniquely poised to address several questions: What proportion of ET cases has Lewy pathology (LP)? What is the nature of that pathology and how does it relate to other comorbidities? Each brain had a complete neuropathological assessment, including \u03b1-synuclein immunostaining. We created a 10-category classification scheme to fully encapsulate the patterns of LP observed. Four metrics of cerebellar pathology were also quantified. Mean age at death\u2009=\u200989.0\u2009\u00b1\u20096.4\u2009years. Fifty-eight (25.1%) had LP and 46 (19.9%) had early to late stages of Parkinson disease (PD). LP was very heterogeneous. Of 58 cases with LP, 14 (24.1%) clinically developed possible PD or PD after a latency of 5 or more years. There was a similar degree of cerebellar pathology in ET cases both with and without LP. In summary, 1 in 4 ET cases had LP\u2014a proportion that seems higher than expected based on studies among control populations. Heterogeneous LP likely reflects clinical associations between ET and PD, and ET with Alzheimer disease-type neuropathology. These data further our understanding of ET and its relatedness to other degenerative diseases.<\/jats:p>","DOI":"10.1093\/jnen\/nlac068","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T10:28:26Z","timestamp":1660213706000},"page":"796-806","source":"Crossref","is-referenced-by-count":37,"title":["Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository"],"prefix":"10.1093","volume":"81","author":[{"given":"Elan D","family":"Louis","sequence":"first","affiliation":[{"name":"From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Iglesias-Hernandez","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora C","family":"Hernandez","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University of Texas Southwestern , Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xena","family":"Flowers","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Han","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul G","family":"Vonsattel","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University , New York, New York, USA"},{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis L","family":"Faust","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"2024032523473656500_nlac068-B1","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1212\/01.wnl.0000218162.80315.b9","article-title":"Neuropathologic findings in essential tremor","volume":"66","author":"Louis","year":"2006","journal-title":"Neurology"},{"key":"2024032523473656500_nlac068-B2","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1212\/01.wnl.0000279339.87987.d7","article-title":"A population-based study of mortality in essential 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