{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:57:52Z","timestamp":1792083472973,"version":"4.4.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis defined by a unique pattern of hyperphosphorylated tau (p-tau) accumulation that begins in neocortical regions of the brain. It is associated with a range of neuropsychological symptoms, but a definitive diagnosis can only be made by postmortem brain examination. In 2018, we instituted CTE screening for all autopsy brains as part of our routine departmental protocol by performing p-tau immunohistochemistry on a restricted set of 3 neocortical blocks (frontal, temporal, and parietal). This strategy allowed us to identify 4 cases of low-stage CTE from 180 consecutive autopsies. Two of the 4 cases had a documented history of brain injury; for the remaining 2 cases, there was a long history of treatment-resistant tonic\/clonic epilepsy suggesting that undocumented brain injuries may have occurred. Our experience indicates that 3-block CTE screening is useful in identifying CTE in routine practice. The results of this study further support the association between prior head injuries and CTE and demonstrate that, albeit uncommon, CTE does occur in the general population. Our findings suggest that p-tau screening should be routinely pursued in brain autopsy, particularly where there is a documented or likely history of traumatic brain injury.<\/jats:p>","DOI":"10.1093\/jnen\/nlac071","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T19:14:34Z","timestamp":1660158874000},"page":"790-795","source":"Crossref","is-referenced-by-count":12,"title":["Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia"],"prefix":"10.1093","volume":"81","author":[{"given":"Catherine M","family":"Suter","sequence":"first","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"},{"name":"School of Medical Sciences, University of Sydney , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Affleck","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Davies","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arran L","family":"Burns","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"},{"name":"Sydney Medical School, University of Sydney , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sy","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"I\u2019Ons","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"},{"name":"Forensic and Analytical Scientific Services , Lidcombe, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Buckland","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Royal Prince Alfred Hospital , Camperdown, NSW, Australia"},{"name":"School of Medical Sciences, University of Sydney , Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"2023110303231202100_nlac071-B1","doi-asserted-by":"crossref","first-page":"880905","DOI":"10.3389\/fneur.2022.880905","article-title":"Chronic traumatic encephalopathy as a preventable environmental disease","volume":"13","author":"Buckland","year":"2022","journal-title":"Front Neurol"},{"key":"2023110303231202100_nlac071-B2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1055\/s-0040-1713632","article-title":"The neuropathology of chronic traumatic encephalopathy: The status of the literature","volume":"40","author":"McKee","year":"2020","journal-title":"Semin Neurol"},{"key":"2023110303231202100_nlac071-B3","first-page":"210","article-title":"The Second NINDS\/NIBIB Consensus Meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy","volume":"80","author":"Bieniek","year":"2021","journal-title":"J Neuropathol Exp Neurol"},{"key":"2023110303231202100_nlac071-B4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury","volume":"68","author":"McKee","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"2023110303231202100_nlac071-B5","first-page":"16","article-title":"Chronic traumatic encephalopathy in two former Australian National Rugby League players","volume":"7","author":"Buckland","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"2023110303231202100_nlac071-B6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/00313029600169653","article-title":"Dementia pugilistica in an alcoholic achondroplastic dwarf","volume":"28","author":"Williams","year":"1996","journal-title":"Pathology"},{"key":"2023110303231202100_nlac071-B7","first-page":"615","article-title":"Detection of CTE in autopsy cohorts using restricted cortical sampling. 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