{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:07:52Z","timestamp":1740150472139,"version":"3.37.3"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The differential effects of sporadic Creutzfeldt-Jakob disease (sCJD) on the hippocampus and other neocortical areas are poorly understood. We aimed to reveal the histological patterns of cellular prion protein (PrPC) and abnormal prion protein (PrPSc) in hippocampi of sCJD patients and normal controls (NCs). Our study examined 18 postmortem sCJD patients (MM1, 14 cases; MM1\u2009+\u20092c, 3 cases; MM1\u2009+\u20092t, 1 case) and 12 NCs. Immunohistochemistry was conducted using 4 primary antibodies, of which 3 targeted the N-terminus of the prion protein (PrP), and 1 (EP1802Y) targeted the C-terminal domain. PrPC expression was abundant in the hippocampus of NCs, and the distribution of PrPC at CA3\/4 was reminiscent of synaptic complexes. In sCJD cases with a disease history of &amp;lt;2\u2009years, antibodies against the N-terminus could not detect synapse-like PrP expression at CA4; however, EP1802Y could characterize the synapse-like expression. PrPSc accumulation and spongiform changes became evident after 2\u2009years of illness, when PrPSc deposits were more noticeably detected by N-terminal-specific antibodies. Our findings highlighted the chronology of histopathological alterations in the CA4 region in sCJD patients.<\/jats:p>","DOI":"10.1093\/jnen\/nlac078","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T16:48:35Z","timestamp":1662396515000},"page":"900-909","source":"Crossref","is-referenced-by-count":0,"title":["Chronological Changes in the Expression Pattern of Hippocampal Prion Proteins During Disease Progression in Sporadic Creutzfeldt-Jakob Disease MM1 Subtype"],"prefix":"10.1093","volume":"81","author":[{"given":"Kaoru","family":"Yagita","sequence":"first","affiliation":[{"name":"From the Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Koyama","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideomi","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"From the Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Aishima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Medicine, University of Saga , Saga, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naokazu","family":"Sasagasako","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuro-Muscular Center, National Omuta Hospital , Omuta, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"},{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University , Fukuoka, 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