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TDP-43 encephalopathy neuropathologic change (LATE-NC). LATE-NC is a common copathology with Alzheimer disease neuropathologic change (ADNC). Data from the National Alzheimer\u2019s Coordinating Center were analyzed to compare clinical features and copathologies of autopsy-confirmed ADNC with versus without comorbid LATE-NC. A total of 735 participants with ADNC alone and 365 with ADNC with LATE-NC were included. Consistent with prior work, brains with LATE-NC had more severe ADNC, more hippocampal sclerosis, and more brain arteriolosclerosis copathologies. Behavioral symptoms and cognitive performance on neuropsychological tests were compared, stratified by ADNC severity (low\/intermediate vs high). Participants with ADNC and LATE-NC were older, had higher ADNC burden, and had worse cognitive performance than participants with ADNC alone. In the low\/intermediate ADNC strata, participants with comorbid LATE-NC had higher prevalence of behavioral symptoms (apathy, disinhibition, agitation, personality change). They also had worsened performance in episodic memory and language\/semantic memory. Differences narrowed in the high ADNC strata, with worsened performance in only episodic memory in the comorbid LATE-NC group. The co-occurrence of LATE-NC with ADNC is associated with a different pattern of behavioral and cognitive performance than ADNC alone, particularly in people with low\/intermediate ADNC burden.<\/jats:p>","DOI":"10.1093\/jnen\/nlac093","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T18:16:27Z","timestamp":1666289787000},"page":"975-987","source":"Crossref","is-referenced-by-count":30,"title":["Symptomatic Profile and Cognitive Performance in Autopsy-Confirmed Limbic-Predominant Age-Related TDP-43 Encephalopathy With Comorbid Alzheimer Disease"],"prefix":"10.1093","volume":"81","author":[{"given":"Kathryn","family":"Gauthreaux","sequence":"first","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mock","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merilee A","family":"Teylan","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E","family":"Culhane","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"},{"name":"Department of Biostatistics, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwun C G","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"},{"name":"Department of Biostatistics, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, Kentucky, USA"},{"name":"Department of Biostatistics, University of Kentucky , Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, Kentucky, USA"},{"name":"Division of Neuropathology, Department of Pathology, University of Kentucky , Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A","family":"Kukull","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, National Alzheimer\u2019s Coordinating Center, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"2024032523484446300_nlac093-B1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"2024032523484446300_nlac093-B2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-020-02211-0","article-title":"Distinct clinicopathologic clusters of persons with TDP-43 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change across the spectrum of Alzheimer\u2019s disease neuropathology: Combined data from 13 community-based or population-based autopsy cohorts","volume":"144","author":"Nelson","year":"2022","journal-title":"Acta Neuropathol"},{"key":"2024032523484446300_nlac093-B6","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1093\/brain\/awaa299","article-title":"Protein contributions to brain atrophy acceleration in Alzheimer\u2019s disease and primary age-related tauopathy","volume":"143","author":"Josephs","year":"2020","journal-title":"Brain"},{"key":"2024032523484446300_nlac093-B7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jnen\/nlz126","article-title":"Limbic predominant age-related TDP-43 encephalopathy (LATE): Clinical and neuropathological associations","volume":"79","author":"Besser","year":"2020","journal-title":"J Neuropathol Exp 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