{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:26:39Z","timestamp":1793125599759,"version":"4.5.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mary S. Easton Center for Alzheimer\u2019s Research and Care"},{"DOI":"10.13039\/100007185","name":"University of California Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS020989"],"award-info":[{"award-number":["R01 NS020989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cerebral microbleeds (CMBs) detected on magnetic resonance imaging are common in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The neuropathologic correlates of CMBs are unclear. In this study, we characterized findings relevant to CMBs in autopsy brain tissue of 8 patients with genetically confirmed CADASIL and 10 controls within the age range of the CADASIL patients by assessing the distribution and extent of hemosiderin\/iron deposits including perivascular hemosiderin leakage (PVH), capillary hemosiderin deposits, and parenchymal iron deposits (PID) in the frontal cortex and white matter, basal ganglia and cerebellum. We also characterized infarcts, vessel wall thickening, and severity of vascular smooth muscle cell degeneration. CADASIL subjects had a significant increase in hemosiderin\/iron deposits compared with controls. This increase was principally seen with PID. Hemosiderin\/iron deposits were seen in the majority of CADASIL subjects in all brain areas. PVH was most pronounced in the frontal white matter and basal ganglia around small to medium sized arterioles, with no predilection for the vicinity of vessels with severe vascular changes or infarcts. CADASIL subjects have increased brain hemosiderin\/iron deposits but these do not occur in a periarteriolar distribution. Pathogenesis of these lesions remains uncertain.<\/jats:p>","DOI":"10.1093\/jnen\/nlad004","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T10:52:01Z","timestamp":1675075921000},"page":"333-344","source":"Crossref","is-referenced-by-count":6,"title":["Neuropathology of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-5759","authenticated-orcid":false,"given":"Shino","family":"Magaki","sequence":"first","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zesheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyscia","family":"Severance","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K","family":"Williams","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro","family":"Diaz","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuo","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California-Irvine School of Medicine , Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Khanlou","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Yong","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annlia","family":"Paganini-Hill","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California-Irvine School of Medicine , Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh N","family":"Kalaria","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University, Campus for Ageing and Vitality , Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry V","family":"Vinters","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"},{"name":"Department of Neurology, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine , Los Angeles, California, USA"},{"name":"Brain Research 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