{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:55:06Z","timestamp":1793451306089,"version":"4.5.0"},"reference-count":151,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institute of Child Health and Development"},{"DOI":"10.13039\/100000071","name":"NICHD","doi-asserted-by":"publisher","award":["R01HD090064"],"award-info":[{"award-number":["R01HD090064"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"NICHD","doi-asserted-by":"publisher","award":["P01HD036379"],"award-info":[{"award-number":["P01HD036379"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert\u2019s Program on Sudden Unexpected Death in Pediatrics"},{"name":"American SIDS Institute","id":[{"id":"https:\/\/ror.org\/04fn5zr38","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001524","name":"CJ Foundation for SIDS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001524","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cooper Trewin Brighter Days Fund, River\u2019s Gift, First Candle","id":[{"id":"https:\/\/ror.org\/03cezf402","id-type":"ROR","asserted-by":"crossref"}]},{"name":"CJ Murphy Foundation for Solving"},{"name":"Puzzle of SIDS"},{"name":"Barrett Tallman Memorial Fund, Florida SIDS Alliance, Jacob Neil Boger Foundation for SIDS"},{"name":"Three Butterflies Foundation"},{"name":"Margot Elizabeth Koslosky Memorial Fund"},{"name":"Jude Theodore Zayac Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality in the United States, is typically associated with a sleep period. Previously, we showed evidence of serotonergic abnormalities in the medulla (e.g. altered serotonin (5-HT)1A receptor binding), in SIDS cases. In rodents, 5-HT2A\/C receptor signaling contributes to arousal and autoresuscitation, protecting brain oxygen status during sleep. Nonetheless, the role of 5-HT2A\/C receptors in the pathophysiology of SIDS is unclear. We hypothesize that in SIDS, 5-HT2A\/C receptor binding is altered in medullary nuclei that are key for arousal and autoresuscitation. Here, we report altered 5-HT2A\/C binding in several key medullary nuclei in SIDS cases (n\u2009=\u200958) compared to controls (n\u2009=\u200912). In some nuclei the reduced 5-HT2A\/C and 5-HT1A binding overlapped, suggesting abnormal 5-HT receptor interactions. The data presented here (Part 1) suggest that a subset of SIDS is due in part to abnormal 5-HT2A\/C and 5-HT1A signaling across multiple medullary nuclei vital for arousal and autoresuscitation. In Part II to follow, we highlight 8 medullary subnetworks with altered 5-HT receptor binding in SIDS. We propose the existence of an integrative brainstem network that fails to facilitate arousal and\/or autoresuscitation in SIDS cases.<\/jats:p>","DOI":"10.1093\/jnen\/nlad030","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T03:20:48Z","timestamp":1684984848000},"page":"467-482","source":"Crossref","is-referenced-by-count":22,"title":["Altered 5-HT2A\/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits"],"prefix":"10.1093","volume":"82","author":[{"given":"Robin L","family":"Haynes","sequence":"first","affiliation":[{"name":"CJ Murphy Laboratory for SIDS Research, Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, Massachusetts, USA"},{"name":"Robert\u2019s Program on Sudden Unexpected Death in Pediatrics, Division of General Pediatrics, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Trachtenberg","sequence":"additional","affiliation":[{"name":"Carelon Research , Newton, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Darnall","sequence":"additional","affiliation":[{"name":"CJ Murphy Laboratory for SIDS Research, Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Research, Rady Children\u2019s Hospital , San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Robert\u2019s Program on Sudden Unexpected Death in Pediatrics, Division of General Pediatrics, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, Massachusetts, USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othon J","family":"Mena","sequence":"additional","affiliation":[{"name":"San Diego County Medical Examiner Office , San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F","family":"Krous","sequence":"additional","affiliation":[{"name":"University of California, San Diego , San Diego, California, USA"},{"name":"Rady Children\u2019s Hospital , San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C","family":"Kinney","sequence":"additional","affiliation":[{"name":"CJ Murphy Laboratory for SIDS Research, Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, Massachusetts, USA"},{"name":"Robert\u2019s Program on Sudden Unexpected Death in Pediatrics, Division of General Pediatrics, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"2024032523521137200_nlad030-B1","doi-asserted-by":"crossref","first-page":"e2022057991","DOI":"10.1542\/peds.2022-057991","article-title":"Evidence base for 2022 updated recommendations for a safe infant sleeping environment to reduce the risk of sleep-related infant deaths","volume":"150","author":"Moon","year":"2022","journal-title":"Pediatrics"},{"key":"2024032523521137200_nlad030-B2","author":"CDC","year":"2020"},{"key":"2024032523521137200_nlad030-B3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s12024-019-00156-9","article-title":"Inconsistent classification of unexplained sudden deaths in infants and children hinders surveillance, prevention and research: Recommendations from The 3rd International Congress on Sudden Infant and Child Death","volume":"15","author":"Goldstein","year":"2019","journal-title":"Forensic Sci Med Pathol"},{"key":"2024032523521137200_nlad030-B4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.embor.7401163","article-title":"Tragic and sudden death. 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