{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:17:03Z","timestamp":1778908623757,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K08 AG065426"],"award-info":[{"award-number":["K08 AG065426"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K08 NS114170"],"award-info":[{"award-number":["K08 NS114170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AG066509"],"award-info":[{"award-number":["P30 AG066509"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AG072946"],"award-info":[{"award-number":["P30 AG072946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19 AG066567"],"award-info":[{"award-number":["U19 AG066567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 NS118584"],"award-info":[{"award-number":["RF1 NS118584"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007512","name":"Nancy and Buster Alvord Endowment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007512","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and Treatment"},{"name":"Department of Veterans Affairs Puget Sound Mental Illness Research, Education, and Clinical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a dementia-related proteinopathy common in the elderly population. LATE-NC stages 2 or 3 are consistently associated with cognitive impairment. A condensed protocol (CP) for the assessment of Alzheimer disease neuropathologic change and other disorders associated with cognitive impairment, recommended sampling of small brain portions from specific neuroanatomic regions that were consolidated, resulting in significant cost reduction. Formal evaluation of the CP for LATE-NC staging was not previously performed. Here, we determined the ability of the CP to identify LATE-NC stages 2 or 3. Forty brains donated to the University of Washington BioRepository and Integrated Neuropathology laboratory with known LATE-NC status were resampled. Slides containing brain regions required for LATE-NC staging were immunostained for phospho-TDP-43 and reviewed by 6 neuropathologists blinded to original LATE-NC diagnosis. Overall group performance distinguishing between LATE-NC stages 0\u20131 and 2\u20133 was 85% (confidence interval [CI]: 75%\u201392%). We also used the CP to evaluate LATE-NC in a hospital autopsy cohort, in which LATE-NC was more common in individuals with a history of cognitive impairment, older age, and\/or comorbid hippocampal sclerosis. This study shows that the CP can effectively discriminate higher stages of LATE-NC from low or no LATE-NC and that it can be successfully applied in clinical practice using a single tissue block and immunostain.<\/jats:p>","DOI":"10.1093\/jnen\/nlad035","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T15:11:17Z","timestamp":1684336277000},"page":"611-619","source":"Crossref","is-referenced-by-count":4,"title":["Performance of a condensed protocol to assess limbic-predominant age-related TDP-43 encephalopathy neuropathologic change"],"prefix":"10.1093","volume":"82","author":[{"given":"Heather","family":"Maioli","sequence":"first","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Mittenzwei","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane B","family":"Shofer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington , Seattle, Washington, USA"},{"name":"Mental Illness Research, Education, and Clinical Center (MIRECC), VA Puget Sound Health Care System , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn P","family":"Scherpelz","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Marshall","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber L","family":"Nolan","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Kentucky , Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-4278","authenticated-orcid":false,"given":"Caitlin S","family":"Latimer","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"2024032523520018000_nlad035-B1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus Working Group Report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"2024032523520018000_nlad035-B2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jnen\/nlz126","article-title":"Limbic predominant age-related TDP-43 encephalopathy (LATE): Clinical and neuropathological associations","volume":"79","author":"Besser","year":"2020","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523520018000_nlad035-B3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00401-014-1358-z","article-title":"Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP type A","volume":"129","author":"Aoki","year":"2015","journal-title":"Acta Neuropathol"},{"key":"2024032523520018000_nlad035-B4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00401-008-0480-1","article-title":"Phosphorylated TDP-43 in Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"117","author":"Arai","year":"2009","journal-title":"Acta Neuropathol"},{"key":"2024032523520018000_nlad035-B5","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00401-014-1269-z","article-title":"TDP-43 is a key player in the clinical features associated with Alzheimer\u2019s disease","volume":"127","author":"Josephs","year":"2014","journal-title":"Acta 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