{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:11:25Z","timestamp":1783033885451,"version":"3.54.6"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012856","name":"Alberta Children\u2019s Hospital Research Institute","doi-asserted-by":"crossref","award":["#60-28450"],"award-info":[{"award-number":["#60-28450"]}],"id":[{"id":"10.13039\/100012856","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peripheral neuroblastic tumors of childhood exhibit 3 principal neural crest lineages: primitive neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. They are unique in undergoing maturation of neurons (ganglion cells) and Schwann cells, thereby recapitulating normal fetal neuronal development in the brain. Precision in estimating neurogenesis is enhanced by immunoreactivities of markers of neuronal maturation. Whether organ tissue factors in different sites of metastases influence rates of maturation and whether metastases are similar to their primary neuroblastic tumor are incompletely documented. Four young children, 1 with a mixed primary adrenal tumor and 3 with metastases were studied at surgery or autopsy. Immunocytochemical reactivities included microtubule-associated protein-2, synaptophysin, chromogranin-A, somatostatin, keratan sulfate, vimentin, S-100\u03b2 protein, and PHOX2B. Primary tumors were non-uniform with regions of either poor or enhanced maturation. Both neuronal and Schwannian lineages were represented in each tumor type but differed in proportions. Bi- or multi-nucleated ganglion cells matured equal to mononuclear forms. Ganglion cell maturation was similar in metastases regardless of the target organ. Metastases resembled primary tumors. Immunocytochemical markers of neuronal and of Schwann cell maturation provide greater diagnostic precision to supplement histological criteria. Interval between diagnosis of primary tumor and metastases, metastatic target tissues, and chemotherapy over an interval of time do not appear to influence neuroblastic or Schwann cell differentiation.<\/jats:p>","DOI":"10.1093\/jnen\/nlad068","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T15:58:37Z","timestamp":1694188717000},"page":"853-864","source":"Crossref","is-referenced-by-count":5,"title":["Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-2959","authenticated-orcid":false,"given":"Harvey B","family":"Sarnat","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University of Calgary Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute (Owerko Centre) , Calgary, Alberta, Canada"},{"name":"Department of Pathology and Laboratory Medicine (Neuropathology), University of Calgary Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute (Owerko Centre) , Calgary, Alberta, Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute (Owerko Centre) , Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine (Paediatric Anatomical Pathology), University of Calgary Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute (Owerko Centre) , Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine (Neuropathology), University of Calgary Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute (Owerko Centre) , Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine (Paediatric Anatomical Pathology), University of Calgary Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute (Owerko Centre) , Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"2024032523534026800_nlad068-B1","first-page":"2678","volume-title":"Nelson Textbook of Pediatrics","author":"Harrison","year":"2020","edition":"21st ed"},{"key":"2024032523534026800_nlad068-B2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/1097-0142(19890315)63:6<1211::AID-CNCR2820630628>3.0.CO;2-1","article-title":"Clinical manifestations of ganglioneuroma","volume":"63","author":"Ann Hayes","year":"1989","journal-title":"Cancer"},{"key":"2024032523534026800_nlad068-B3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1573396314666180129101627","article-title":"Biological and genetic features of neuroblastoma and their clinical importance","volume":"14","author":"Aygun","year":"2018","journal-title":"Curr Pediatr Rev"},{"key":"2024032523534026800_nlad068-B4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00441-018-2796-z","article-title":"Origin and initiation mechanisms of neuroblastoma","volume":"372","author":"Tsubota","year":"2018","journal-title":"Cell Tissue Res"},{"key":"2024032523534026800_nlad068-B5","first-page":"107","article-title":"Pathology of neuroblastic tumors","volume":"11","author":"Joshi","year":"1994","journal-title":"Semin Diag Pathol"},{"key":"2024032523534026800_nlad068-B6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0046-8177(96)90304-4","article-title":"Stage IVS neuroblastoma: A clinical, histological and biological analysis of 45 cases","volume":"27","author":"Hachitanda","year":"1996","journal-title":"Hum Pathol"},{"key":"2024032523534026800_nlad068-B7","first-page":"1659","volume-title":"Potter\u2019s Pathology of the Fetus, Infant and Child","author":"Gilbert-Barness","year":"2007","edition":"2nd ed"},{"key":"2024032523534026800_nlad068-B8","first-page":"18","volume-title":"Diagnostic Pathology. 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