{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:01:42Z","timestamp":1766088102556,"version":"3.37.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To follow our 2016 study of chronic traumatic encephalopathy neuropathologic change (CTE-NC) in our forensic autopsy service, we prospectively screened all cases with clinical histories of multiple concussions, persistent post-head injury symptoms, or \u22653 hospital investigations for head injuries from 2016 to 2022 inclusive using hyperphosphorylated tau (p-tau) immunostaining. The cases had routine brain sampling plus 4-6 additional lateral hemisphere samples. When \u201cpathognomonic\u201d CTE-NC lesions were identified, additional p-tau immunostaining was done for CTE-NC staging. Of \u223c1100 adult brains aged 18\u201365\u2009years examined, 85 were screened, and 16 were positive for CTE-NC (2 women, 14 men, ages 35\u201361\u2009years, median 47\u2009years). Alcohol abuse was documented in 14 of 16 (8 in combination with other substances); 5 had developmental brain anomalies (2 presumed genetic, 3 from acquired perinatal insults). Widespread p-tau deposits (high CTE-NC) were found in 7 of 16. Old brain contusions were present in 9 of 16, but CTE-NC did not colocalize. Of particular interest were (1) a man with FGFR3 mutation\/hypochondroplasia and life-long head banging, (2) a woman with cerebral palsy and life-long head banging, and (3) a man with bilateral peri-Sylvian polymicrogyria, alcohol abuse, and multiple head injuries. Thus, CTE-NC occurs in association with repeated head trauma outside contact sports. Substance abuse is a common determinant of risk behavior. The utility of diagnosing mild-\/low-stage CTE-NC in this population remains to be determined.<\/jats:p>","DOI":"10.1093\/jnen\/nlad079","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T11:35:33Z","timestamp":1697542533000},"page":"948-957","source":"Crossref","is-referenced-by-count":5,"title":["Chronic traumatic encephalopathy-neuropathologic change in a routine neuropathology service: 7-year follow-up"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-0394","authenticated-orcid":false,"given":"Marc R","family":"Del Bigio","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Manitoba & Shared Health Manitoba , Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry","family":"Krawitz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Manitoba & Shared Health Manitoba , Winnipeg, Manitoba, 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