{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T01:36:50Z","timestamp":1794620210785,"version":"4.9.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG078505"],"award-info":[{"award-number":["R21 AG078505"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020423","name":"Texas Alzheimer\u2019s Research and Care Consortium","doi-asserted-by":"crossref","award":["957581"],"award-info":[{"award-number":["957581"]}],"id":[{"id":"10.13039\/100020423","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020423","name":"Texas Alzheimer\u2019s Research and Care Consortium","doi-asserted-by":"crossref","award":["957607"],"award-info":[{"award-number":["957607"]}],"id":[{"id":"10.13039\/100020423","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U24 AG072122"],"award-info":[{"award-number":["U24 AG072122"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a neuropathologic entity characterized by transactive response DNA-binding protein of 43-kDa (TDP-43)-immunoreactive inclusions that originate in the amygdala and then progress to the hippocampi and middle frontal gyrus. LATE-NC may mimic Alzheimer disease clinically and often co-occurs with Alzheimer disease neuropathologic change (ADNC). This report focuses on the cognitive effects of isolated and concomitant LATE-NC and ADNC. Cognitive\/neuropsychological, neuropathologic, genetic, and demographic variables were analyzed in 28 control, 31 isolated LATE-NC, 244 isolated ADNC, and 172 concurrent LATE-NC\/ADNC subjects from the National Alzheimer\u2019s Coordinating Center. Cases with LATE-NC and ADNC were significantly older than controls; cases with ADNC had a significantly higher proportion of cases with at least one APOE \u03b54 allele. Both LATE-NC and ADNC exhibited deleterious effects on overall cognition proportional to their neuropathological stages; concurrent LATE-NC\/ADNC exhibited the worst overall cognitive effect. Multivariate logistic regression analysis determined an independent risk of cognitive impairment for progressive LATE-NC stages (OR 1.66; p\u2009=\u20090.0256) and ADNC levels (OR 3.41; p\u2009&amp;lt;\u20090.0001). These data add to the existing knowledge on the clinical consequences of LATE-NC pathology and the growing literature on the effects of multiple concurrent neurodegenerative pathologies.<\/jats:p>","DOI":"10.1093\/jnen\/nlad098","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:55:23Z","timestamp":1700074523000},"page":"2-10","source":"Crossref","is-referenced-by-count":24,"title":["Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease"],"prefix":"10.1093","volume":"83","author":[{"given":"Satomi","family":"Hiya","sequence":"first","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Maldonado-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, New York, USA"},{"name":"Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-5517","authenticated-orcid":false,"given":"Timothy E","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"2024032523545431400_nlad098-B1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"2024032523545431400_nlad098-B2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/jnen\/nlw033","article-title":"New old pathologies\u201d: AD, PART, and cerebral age-related TDP-43 with sclerosis (CARTS)","volume":"75","author":"Nelson","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523545431400_nlad098-B3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41582-023-00846-7","article-title":"Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases","volume":"19","author":"Nag","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"2024032523545431400_nlad098-B4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1212\/WNL.0000000000003610","article-title":"TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD","volume":"88","author":"Nag","year":"2017","journal-title":"Neurology"},{"key":"2024032523545431400_nlad098-B5","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/brain\/awz224","article-title":"LATE to the PART-y","volume":"142","author":"Josephs","year":"2019","journal-title":"Brain"},{"key":"2024032523545431400_nlad098-B6","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1093\/brain\/awad145","article-title":"Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies","volume":"146","author":"Young","year":"2023","journal-title":"Brain"},{"key":"2024032523545431400_nlad098-B7","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/jnen\/nlab098","article-title":"Differences in symptomatic presentation and cognitive performance among participants with LATE-NC compared to FTLD-TDP","volume":"80","author":"Teylan","year":"2021","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523545431400_nlad098-B8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-022-02524-2","article-title":"LATE-NC staging in routine neuropathologic diagnosis: An update","volume":"145","author":"Nelson","year":"2023","journal-title":"Acta Neuropathol"},{"key":"2024032523545431400_nlad098-B9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/jnen\/nlab050","article-title":"LATE neuropathologic changes with little or no Alzheimer disease is common and is associated with cognitive impairment but not 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