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In Part I, we showed that some SIDS infants had altered 5-hydroxytryptamine (5-HT)2A\/C receptor binding in medullary nuclei supporting chemoreflexes, arousal, and autoresuscitation. Here, using the same dataset, we tested the hypotheses that the prevalence of low 5-HT1A and\/or 5-HT2A\/C receptor binding (defined as levels below the 95% confidence interval of controls\u2014a new approach), and the percentages of nuclei affected are greater in SIDS versus controls, and that the distribution of low binding varied with age of death. The prevalence and percentage of nuclei with low 5-HT1A and 5-HT2A\/C binding in SIDS were twice that of controls. The percentage of nuclei with low 5-HT2A\/C binding was greater in older SIDS infants. In &amp;gt;80% of older SIDS infants, low 5-HT2A\/C binding characterized the hypoglossal nucleus, vagal dorsal nucleus, nucleus of solitary tract, and nuclei of the olivocerebellar subnetwork (important for blood pressure regulation). Together, our findings from SIDS infants and from animal models of serotonergic dysfunction suggest that some SIDS cases represent a serotonopathy. We present new hypotheses, yet to be tested, about how defects within serotonergic subnetworks may lead to SIDS.<\/jats:p>","DOI":"10.1093\/jnen\/nlae004","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:08:05Z","timestamp":1704730085000},"page":"144-160","source":"Crossref","is-referenced-by-count":11,"title":["Altered 5-HT2A\/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4100-8856","authenticated-orcid":false,"given":"Kevin J","family":"Cummings","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri , Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C","family":"Leiter","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia L","family":"Trachtenberg","sequence":"additional","affiliation":[{"name":"Clinical Research, Carelon Research , Newton, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin W","family":"Okaty","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Darnall","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Research, Rady\u2019s Children\u2019s Hospital , San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and the Brain Research Institute, David Geffen School of Medicine at UCLA , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene E","family":"Nattie","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F","family":"Krous","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego , San Diego, California, USA"},{"name":"Departments of Pathology and Pediatrics, Rady Children\u2019s Hospital , San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othon J","family":"Mena","sequence":"additional","affiliation":[{"name":"San Diego County Medical Examiner Office , San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B","family":"Richerson","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Molecular Physiology & Biophysics, University of Iowa , Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Dymecki","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C","family":"Kinney","sequence":"additional","affiliation":[{"name":"Department of Pathology, CJ Murphy Laboratory for SIDS Research, Boston Children\u2019s Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L","family":"Haynes","sequence":"additional","affiliation":[{"name":"Department of Pathology, CJ Murphy Laboratory for SIDS Research, Boston Children\u2019s Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"2024032523555836200_nlae004-B1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s12024-019-00156-9","article-title":"Inconsistent classification of unexplained sudden deaths in infants and children hinders surveillance, prevention and research: Recommendations from The 3rd International Congress on Sudden Infant and Child Death","volume":"15","author":"Goldstein","year":"2019","journal-title":"Forensic Sci Med Pathol"},{"key":"2024032523555836200_nlae004-B2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1542\/peds.114.1.234","article-title":"Sudden infant death syndrome and unclassified sudden infant deaths: A definitional and diagnostic approach. 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