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We evaluated CTE-NC, ARTAG, and Alzheimer disease pathologies in 94 participants with msTBI and 94 participants without TBI matched by age, sex, education, and dementia status TBI from the Rush community-based cohorts. Six (3%) of brains showed the pathognomonic lesion of CTE-NC; only 3 of these had a history of msTBI. In contrast, ARTAG was common in older brains (gray matter ARTAG\u2009=\u200977%; white matter ARTAG\u2009=\u200954%; subpial ARTAG\u2009=\u200951%); there were no differences in severity, type, or distribution of ARTAG pathology with respect to history of msTBI. Furthermore, those with msTBI did not have higher levels of PHF-tau tangles density but had higher levels of amyloid-\u03b2 load (Estimate\u2009=\u20090.339, SE\u2009=\u20090.164, p\u2009=\u20090.040). These findings suggest that CTE-NC is infrequent while ARTAG is common in the community and that both pathologies are unrelated to msTBI. The association of msTBI with amyloid-\u03b2, rather than with tauopathies suggests differential mechanisms of neurodegeneration in msTBI.<\/jats:p>","DOI":"10.1093\/jnen\/nlae007","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:35:05Z","timestamp":1706808905000},"page":"181-193","source":"Crossref","is-referenced-by-count":9,"title":["Chronic traumatic encephalopathy and aging-related tau astrogliopathy in community-dwelling older persons with and without moderate-to-severe traumatic brain injury"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2375-8888","authenticated-orcid":false,"given":"Sonal","family":"Agrawal","sequence":"first","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, Illinois, USA"},{"name":"Department of Pathology, Rush University Medical Center , Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E","family":"Leurgans","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, Illinois, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center , Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L","family":"Barnes","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, Illinois, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center , Chicago, Illinois, USA"},{"name":"Department of Behavioral Sciences, Rush University Medical Center , Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Dams-O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Mt Sinai School of Medicine , New York, New York, USA"},{"name":"Department of Neurology, Mt Sinai School of Medicine , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Mez","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer\u2019s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine , Boston, Massachusetts, USA"},{"name":"Boston University Chronic Traumatic Encephalopathy Center, Boston University Chobanian & Avedisian School of Medicine , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, Illinois, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center , Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie 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