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Neurons of the neostriatum are counted to determine relative loss in striosomes versus matrix at early stages, including for the first time in preclinical cases. An immunohistochemical procedure is described that tentatively distinguishes early HD from HD mimic disorders in postmortem brains. Counts of striatal projection neurons (SPNs) in striosomes defined by calbindin immunohistochemistry versus counts in the surrounding matrix are reported for 8 Vonsattel grade 0 (including 5 premanifest), 8 grade 1, 2 grade 2 HD, and for 8 control postmortem brains. Mean counts of striosome and matrix SPNs were significantly lower in premanifest grade 0 versus controls, with striosome counts significantly lower than matrix. In 8 grade 1 and 2 grade 2 brains, no striosomes with higher SPN counts than in the surrounding matrix were observed. Comparing dorsal versus ventral neostriatum, SPNs in dorsal striosomes and matrix declined more than ventral, making clear the importance of the dorsoventral site of tissue selection for research studies. A characteristic pattern of expanded polyglutamine-immunopositive inclusions was seen in all HD cases. Inclusions were always present in some SPNs and some pontine nucleus neurons and were absent in Purkinje cells, which showed no obvious cell loss.<\/jats:p>","DOI":"10.1093\/jnen\/nlae022","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:56:10Z","timestamp":1711760170000},"page":"294-306","source":"Crossref","is-referenced-by-count":21,"title":["Postmortem neuropathology in early Huntington disease"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5307-225X","authenticated-orcid":false,"given":"John C","family":"Hedreen","sequence":"first","affiliation":[{"name":"Harvard Brain Tissue Resource Center, McLean Hospital , Belmont, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Berretta","sequence":"additional","affiliation":[{"name":"McLean Hospital , Belmont, Massachusetts, USA"},{"name":"Department of Psychiatry, Harvard Medical School , Boston, 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