{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:31:51Z","timestamp":1762342311625,"version":"3.37.3"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report the novel clinical presentation of a primary brain neoplasm in a 30-year-old man with a mass-like area in the anteromedial temporal lobe. Histopathological analysis revealed a low-grade neuroepithelial tumor with cytologically abnormal neurons and atypical glial cells within the cerebral cortex. Molecular analysis showed a previously undescribed FGFR2::DLG5 rearrangement. We discuss the clinical significance and molecular implications of this fusion event, shedding light on its potential impact on tumor development and patient prognosis. Additionally, an extensive review places the finding in this case in the context of protein fusions in brain tumors in general and highlights their diverse manifestations, underlying molecular mechanisms, and therapeutic implications.<\/jats:p>","DOI":"10.1093\/jnen\/nlae040","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T03:56:15Z","timestamp":1717559775000},"page":"567-578","source":"Crossref","is-referenced-by-count":1,"title":["Exploring a distinct <i>FGFR2::DLG5<\/i> rearrangement in a low-grade neuroepithelial tumor: A case report and mini-review of protein fusions in brain tumors"],"prefix":"10.1093","volume":"83","author":[{"given":"Paola","family":"Loreto Palacio","sequence":"first","affiliation":[{"name":"Abigail Wexner Center Research Institute, Nationwide Children\u2019s Hospital , Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokang","family":"Pan","sequence":"additional","affiliation":[{"name":"James Molecular Laboratory, James Cancer Hospital , Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center , Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-4520","authenticated-orcid":false,"given":"Jos\u00e9 Javier","family":"Otero","sequence":"additional","affiliation":[{"name":"Neuropathology Division, Pathology Department, The Ohio State University Wexner Medical Center , Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"2024062007514183800_nlae040-B1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1021\/acsptsci.9b00019","article-title":"Molecular signatures of fusion proteins in cancer","volume":"2","author":"Latysheva","year":"2019","journal-title":"ACS Pharmacol Transl Sci"},{"key":"2024062007514183800_nlae040-B2","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.3390\/molecules25081864","article-title":"Use of fluorescence in situ hybridization (FISH) in diagnosis and tailored therapies in solid tumors","volume":"25","author":"Chrzanowska","year":"2020","journal-title":"Molecules"},{"key":"2024062007514183800_nlae040-B3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/shem.2003.50034","article-title":"Molecular mechanisms of transformation by the BCR-ABL oncogene","volume":"40","author":"Sattler","year":"2003","journal-title":"Semin Hematol"},{"key":"2024062007514183800_nlae040-B4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/path.2632","article-title":"Fusion genes and chromosome translocations in the common epithelial cancers","volume":"220","author":"Edwards","year":"2010","journal-title":"J Pathol"},{"key":"2024062007514183800_nlae040-B5","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1200\/JCO.2011.35.1916","article-title":"Common gene rearrangements in prostate cancer","volume":"29","author":"Rubin","year":"2011","journal-title":"J Clin Oncol"},{"key":"2024062007514183800_nlae040-B6","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1158\/0008-5472.CAN-16-0058","article-title":"Diverse, biologically relevant, and targetable gene rearrangements in triple-negative breast cancer and other malignancies","volume":"76","author":"Shaver","year":"2016","journal-title":"Cancer Res"},{"key":"2024062007514183800_nlae040-B7","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1158\/2159-8290.CD-21-0226","article-title":"Targeting EGFR exon 20 insertions in non-small cell lung cancer: Recent advances and clinical updates","volume":"11","author":"Meador","year":"2021","journal-title":"Cancer Discov"},{"key":"2024062007514183800_nlae040-B8","doi-asserted-by":"crossref","first-page":"8337","DOI":"10.1158\/0008-5472.CAN-06-1482","article-title":"TMPRSS2: ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer","volume":"66","author":"Perner","year":"2006","journal-title":"Cancer Res"},{"key":"2024062007514183800_nlae040-B9","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/modpathol.3800903","article-title":"Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: Frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues","volume":"20","author":"Tu","year":"2007","journal-title":"Mod Pathol"},{"key":"2024062007514183800_nlae040-B10","doi-asserted-by":"crossref","first-page":"e2205483","DOI":"10.1002\/advs.202205483","article-title":"Targeting the lysosomal degradation of Rab22a-NeoF1 fusion protein for osteosarcoma lung metastasis","volume":"10","author":"Zeng","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2024062007514183800_nlae040-B11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/0008-5472.CAN-18-1492","article-title":"Differential subcellular localization regulates oncogenic signaling by ROS1 kinase fusion proteins","volume":"79","author":"Neel","year":"2019","journal-title":"Cancer Res"},{"key":"2024062007514183800_nlae040-B12","doi-asserted-by":"crossref","first-page":"619","DOI":"10.18632\/oncotarget.27478","article-title":"In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy","volume":"11","author":"Al-Mansoori","year":"2020","journal-title":"Oncotarget"},{"key":"2024062007514183800_nlae040-B13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1750-3639.2008.00225.x","article-title":"Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene","volume":"19","author":"Sievert","year":"2009","journal-title":"Brain Pathol"},{"key":"2024062007514183800_nlae040-B14","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/sj.onc.1210255","article-title":"Oncogenic re-wiring of cellular signaling pathways","volume":"26","author":"Pawson","year":"2007","journal-title":"Oncogene"},{"key":"2024062007514183800_nlae040-B15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00401-022-02405-8","article-title":"The oncogenic fusion landscape in pediatric CNS neoplasms","volume":"143","author":"Roosen","year":"2022","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B16","doi-asserted-by":"crossref","first-page":"e28028","DOI":"10.1002\/pbc.28028","article-title":"Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors","volume":"67","author":"Lake","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"2024062007514183800_nlae040-B17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tranon.2018.02.020","article-title":"Gene fusion in malignant glioma: An emerging target for next-generation personalized treatment","volume":"11","author":"Xu","year":"2018","journal-title":"Transl Oncol"},{"key":"2024062007514183800_nlae040-B18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jmoldx.2023.11.004","article-title":"FindDNAFusion: An analytical pipeline with multiple software tools improves detection of cancer-associated gene fusions from genomic DNA","volume":"26","author":"Pan","year":"2024","journal-title":"J Mol Diagn"},{"key":"2024062007514183800_nlae040-B19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00401-021-02352-w","article-title":"Low-grade glioneuronal tumors with FGFR2 fusion resolve into a single epigenetic group corresponding to \u2018Polymorphous low-grade neuroepithelial tumor of the young\u2019","volume":"142","author":"Gupta","year":"2021","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1227\/00006123-198811000-00002","article-title":"Dysembryoplastic neuroepithelial tumor: A surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases","volume":"23","author":"Daumas-Duport","year":"1988","journal-title":"Neurosurgery"},{"key":"2024062007514183800_nlae040-B21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/nan.12522","article-title":"Review: Challenges in the histopathological classification of ganglioglioma and DNT: Microscopic agreement studies and a preliminary genotype-phenotype analysis","volume":"45","author":"Blumcke","year":"2019","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2024062007514183800_nlae040-B22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12883-020-01679-3","article-title":"Polymorphous low-grade neuroepithelial tumor of the young: Case report and review focus on the radiological features and genetic alterations","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Neurol"},{"key":"2024062007514183800_nlae040-B23","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00234-019-02269-y","article-title":"Plenty of calcification: Imaging characterization of polymorphous low-grade neuroepithelial tumor of the young","volume":"61","author":"Johnson","year":"2019","journal-title":"Neuroradiology"},{"key":"2024062007514183800_nlae040-B24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00401-016-1639-9","article-title":"Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): An epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway","volume":"133","author":"Huse","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40478-018-0551-z","article-title":"The genetic landscape of ganglioglioma","volume":"6","author":"Pekmezci","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"2024062007514183800_nlae040-B26","first-page":"e20674","article-title":"Multinodular and vacuolating neuronal tumor: Incidental diagnosis of a rare brain lesion","volume":"13","author":"Arbuiso","year":"2021","journal-title":"Cureus"},{"key":"2024062007514183800_nlae040-B27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/bpa.12035","article-title":"Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion","volume":"23","author":"Huse","year":"2013","journal-title":"Brain Pathol"},{"key":"2024062007514183800_nlae040-B28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/bpa.12555","article-title":"Multinodular and vacuolating neuronal tumors in epilepsy: Dysplasia or neoplasia?","volume":"28","author":"Thom","year":"2018","journal-title":"Brain Pathol"},{"key":"2024062007514183800_nlae040-B29","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1101\/gad.284539.116","article-title":"DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1\/2","volume":"30","author":"Kwan","year":"2016","journal-title":"Genes Dev"},{"key":"2024062007514183800_nlae040-B30","doi-asserted-by":"crossref","first-page":"42125","DOI":"10.1038\/srep42125","article-title":"Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"2024062007514183800_nlae040-B31","doi-asserted-by":"crossref","first-page":"21709","DOI":"10.1074\/jbc.M211004200","article-title":"Interaction of lp-dlg\/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact","volume":"278","author":"Wakabayashi","year":"2003","journal-title":"J Biol Chem"},{"key":"2024062007514183800_nlae040-B32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.7150\/ijbs.8888","article-title":"DLG5 in cell polarity maintenance and cancer development","volume":"10","author":"Liu","year":"2014","journal-title":"Int J Biol Sci"},{"key":"2024062007514183800_nlae040-B33","doi-asserted-by":"crossref","first-page":"e35519","DOI":"10.1371\/journal.pone.0035519","article-title":"Role of Dlg5\/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells","volume":"7","author":"Sezaki","year":"2012","journal-title":"PLoS One"},{"key":"2024062007514183800_nlae040-B34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/onc.2014.31","article-title":"Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation","volume":"34","author":"Tomiyama","year":"2015","journal-title":"Oncogene"},{"key":"2024062007514183800_nlae040-B35","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1042\/BST20180004","article-title":"Structure, activation and dysregulation of fibroblast growth factor receptor kinases: Perspectives for clinical targeting","volume":"46","author":"Farrell","year":"2018","journal-title":"Biochem Soc Trans"},{"key":"2024062007514183800_nlae040-B36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40478-020-00898-6","article-title":"FGFR- gene family alterations in low-grade neuroepithelial tumors","volume":"8","author":"Bale","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"2024062007514183800_nlae040-B37","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1523\/JNEUROSCI.3316-16.2017","article-title":"Signaling by FGF receptor 2, not FGF receptor 1, regulates myelin thickness through activation of ERK1\/2-MAPK, which promotes mTORC1 activity in an Akt-independent manner","volume":"37","author":"Furusho","year":"2017","journal-title":"J Neurosci"},{"key":"2024062007514183800_nlae040-B38","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4161\/cc.8.4.7657","article-title":"Paths of FGFR-driven tumorigenesis","volume":"8","author":"Acevedo","year":"2009","journal-title":"Cell Cycle"},{"key":"2024062007514183800_nlae040-B39","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41416-022-01908-1","article-title":"Genomic architecture of FGFR2 fusions in cholangiocarcinoma and its implication for molecular testing","volume":"127","author":"Neumann","year":"2022","journal-title":"Br J Cancer"},{"key":"2024062007514183800_nlae040-B40","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1038\/sj.onc.1201057","article-title":"Nuclear accumulation of fibroblast growth factor receptors in human glial cells\u2014association with cell proliferation","volume":"14","author":"Stachowiak","year":"1997","journal-title":"Oncogene"},{"key":"2024062007514183800_nlae040-B41","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/neuonc\/noac001","article-title":"The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells","volume":"24","author":"Kundu","year":"2022","journal-title":"Neuro Oncol"},{"key":"2024062007514183800_nlae040-B42","doi-asserted-by":"crossref","first-page":"715206","DOI":"10.3389\/fneur.2021.715206","article-title":"Fusion genes altered in adult malignant gliomas","volume":"12","author":"You","year":"2021","journal-title":"Front Neurol"},{"key":"2024062007514183800_nlae040-B43","doi-asserted-by":"crossref","first-page":"15017","DOI":"10.1038\/nrdp.2015.17","article-title":"Glioma","volume":"1","author":"Weller","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2024062007514183800_nlae040-B44","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1158\/0008-5472.CAN-08-2097","article-title":"Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas","volume":"68","author":"Jones","year":"2008","journal-title":"Cancer Res"},{"key":"2024062007514183800_nlae040-B45","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/0883073820937225","article-title":"Pilocytic astrocytoma: A review of general, clinical, and molecular characteristics","volume":"35","author":"Salles","year":"2020","journal-title":"J Child Neurol"},{"key":"2024062007514183800_nlae040-B46","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/path.2780","article-title":"MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential","volume":"222","author":"Jeuken","year":"2010","journal-title":"J Pathol"},{"key":"2024062007514183800_nlae040-B47","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jocn.2019.05.014","article-title":"Clinical relevance of BRAF status in glial and glioneuronal tumors: A systematic review","volume":"66","author":"Sugiura","year":"2019","journal-title":"J Clin Neurosci"},{"key":"2024062007514183800_nlae040-B48","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/NEN.0000000000000226","article-title":"BRAF fusion analysis in pilocytic astrocytomas: KIAA1549-BRAF 15-9 fusions are more frequent in the midline than within the cerebellum","volume":"74","author":"Faulkner","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024062007514183800_nlae040-B49","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1158\/1078-0432.CCR-14-2199","article-title":"Detection, characterization, and inhibition of FGFR-TACC fusions in IDH wild-type glioma","volume":"21","author":"Di Stefano","year":"2015","journal-title":"Clin Cancer Res"},{"key":"2024062007514183800_nlae040-B50","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000524399","article-title":"Larotrectinib response in NTRK3 fusion-driven diffuse high-grade glioma","volume":"107","author":"Konig","year":"2022","journal-title":"Pharmacology"},{"key":"2024062007514183800_nlae040-B51","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.3390\/cancers13225838","article-title":"Identification of an immunogenic medulloblastoma-specific fusion involving EPC2 and GULP1","volume":"13","author":"Paret","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2024062007514183800_nlae040-B52","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: A summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"2024062007514183800_nlae040-B53","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1158\/2159-8290.CD-20-1066","article-title":"ZFTA-RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial ependymoma","volume":"11","author":"Arabzade","year":"2021","journal-title":"Cancer Discov"},{"key":"2024062007514183800_nlae040-B54","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/jnen\/nlad038","article-title":"ZFTA-fused supratentorial ependymoma with a novel fusion partner, DUX4","volume":"82","author":"Gubbiotti","year":"2023","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024062007514183800_nlae040-B55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/bpa.12659","article-title":"Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: An entity with characteristic clinical, radiological, cytogenetic and histopathological features","volume":"29","author":"Andreiuolo","year":"2019","journal-title":"Brain Pathol"},{"key":"2024062007514183800_nlae040-B56","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1038\/s41467-019-11884-5","article-title":"YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis","volume":"10","author":"Pajtler","year":"2019","journal-title":"Nat Commun"},{"key":"2024062007514183800_nlae040-B57","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1750-3639.2012.00603.x","article-title":"KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults","volume":"22","author":"Badiali","year":"2012","journal-title":"Brain Pathol"},{"key":"2024062007514183800_nlae040-B58","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cancergen.2015.01.009","article-title":"Oncogenic KIAA1549-BRAF fusion with activation of the MAPK\/ERK pathway in pediatric oligodendrogliomas","volume":"208","author":"Kumar","year":"2015","journal-title":"Cancer Genet"},{"key":"2024062007514183800_nlae040-B59","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ng.2734","article-title":"The integrated landscape of driver genomic alterations in glioblastoma","volume":"45","author":"Frattini","year":"2013","journal-title":"Nat Genet"},{"key":"2024062007514183800_nlae040-B60","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature25171","article-title":"A metabolic function of FGFR3-TACC3 gene fusions in cancer","volume":"553","author":"Frattini","year":"2018","journal-title":"Nature"},{"key":"2024062007514183800_nlae040-B61","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1158\/0008-5472.CAN-12-4039","article-title":"The MET oncogene in glioblastoma stem cells: Implications as a diagnostic marker and a therapeutic target","volume":"73","author":"Boccaccio","year":"2013","journal-title":"Cancer Res"},{"key":"2024062007514183800_nlae040-B62","doi-asserted-by":"crossref","first-page":"e91940","DOI":"10.1371\/journal.pone.0091940","article-title":"NTRK1 fusion in glioblastoma multiforme","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"2024062007514183800_nlae040-B63","doi-asserted-by":"crossref","first-page":"e000023","DOI":"10.1136\/esmoopen-2015-000023","article-title":"NTRK gene fusions as novel targets of cancer therapy across multiple tumour types","volume":"1","author":"Amatu","year":"2016","journal-title":"ESMO Open"},{"key":"2024062007514183800_nlae040-B64","doi-asserted-by":"crossref","first-page":"593578","DOI":"10.3389\/fonc.2020.593578","article-title":"NTRK fusions and TRK inhibitors: Potential targeted therapies for adult glioblastoma","volume":"10","author":"Wang","year":"2020","journal-title":"Front Oncol"},{"key":"2024062007514183800_nlae040-B65","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-019-02078-w","article-title":"Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course","volume":"139","author":"Wefers","year":"2020","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41389-021-00309-y","article-title":"MYB oncoproteins: Emerging players and potential therapeutic targets in human cancer","volume":"10","author":"Ciciro","year":"2021","journal-title":"Oncogenesis"},{"key":"2024062007514183800_nlae040-B67","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00401-019-02081-1","article-title":"A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration","volume":"138","author":"Chiang","year":"2019","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jhep.2021.02.032","article-title":"FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma","volume":"75","author":"Cristinziano","year":"2021","journal-title":"J Hepatol"},{"key":"2024062007514183800_nlae040-B69","doi-asserted-by":"crossref","first-page":"25049","DOI":"10.1074\/jbc.271.40.25049","article-title":"Ligand-independent activation of fibroblast growth factor receptors by point mutations in the extracellular, transmembrane, and kinase domains","volume":"271","author":"Neilson","year":"1996","journal-title":"J Biol Chem"},{"key":"2024062007514183800_nlae040-B70","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1126\/science.1220834","article-title":"Transforming fusions of FGFR and TACC genes in human glioblastoma","volume":"337","author":"Singh","year":"2012","journal-title":"Science"},{"key":"2024062007514183800_nlae040-B71","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1038\/s41467-019-12187-5","article-title":"Alterations in ALK\/ROS1\/NTRK\/MET drive a group of infantile hemispheric gliomas","volume":"10","author":"Guerreiro Stucklin","year":"2019","journal-title":"Nat Commun"},{"key":"2024062007514183800_nlae040-B72","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cancergen.2020.12.005","article-title":"Genomic characterization of a PPP1CB-ALK fusion with fusion gene amplification in a congenital glioblastoma","volume":"252-253","author":"Zhong","year":"2021","journal-title":"Cancer Genet"},{"key":"2024062007514183800_nlae040-B73","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/cancers15174246","article-title":"The impact of ETV6-NTRK3 oncogenic gene fusions on molecular and signaling pathway alterations","volume":"15","author":"Kinnunen","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2024062007514183800_nlae040-B74","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/BJ20041523","article-title":"Activated STAT5 proteins induce activation of the PI 3-kinase\/Akt and Ras\/MAPK pathways via the Gab2 scaffolding adapter","volume":"390","author":"Nyga","year":"2005","journal-title":"Biochem J"},{"key":"2024062007514183800_nlae040-B75","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41388-019-1021-1","article-title":"Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains","volume":"39","author":"Weinberg","year":"2020","journal-title":"Oncogene"},{"key":"2024062007514183800_nlae040-B76","first-page":"855","article-title":"The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma","volume":"123","author":"Parker","year":"2013","journal-title":"J Clin Invest"},{"key":"2024062007514183800_nlae040-B77","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cancergen.2016.09.002","article-title":"A new NFIA: RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma","volume":"209","author":"Yde","year":"2016","journal-title":"Cancer Genet"},{"key":"2024062007514183800_nlae040-B78","first-page":"5903863","article-title":"Neurotrophic receptor tyrosine kinase 2 (NTRK2) alterations in low-grade gliomas: Report of a novel gene fusion partner in a pilocytic astrocytoma and review of the literature","volume":"2020","author":"Pattwell","year":"2020","journal-title":"Case Rep Pathol"},{"key":"2024062007514183800_nlae040-B79","doi-asserted-by":"crossref","first-page":"eabo6789","DOI":"10.1126\/sciadv.abo6789","article-title":"Oncogenic role of a developmentally regulated NTRK2 splice variant","volume":"8","author":"Pattwell","year":"2022","journal-title":"Sci Adv"},{"key":"2024062007514183800_nlae040-B80","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2016.01.015","article-title":"New brain tumor entities emerge from molecular classification of CNS-PNETs","volume":"164","author":"Sturm","year":"2016","journal-title":"Cell"},{"key":"2024062007514183800_nlae040-B81","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1182\/blood-2007-03-080523","article-title":"MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML","volume":"110","author":"Heuser","year":"2007","journal-title":"Blood"},{"key":"2024062007514183800_nlae040-B82","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/sj.onc.1206124","article-title":"The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription","volume":"22","author":"van Wely","year":"2003","journal-title":"Oncogene"},{"key":"2024062007514183800_nlae040-B83","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/cancers11060794","article-title":"Oncogenic BRAF alterations and their role in brain tumors","volume":"11","author":"Behling","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2024062007514183800_nlae040-B84","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000535842","article-title":"A case report of infant-type hemispheric glioma with a novel GAB1-ABL2 kinase fusion treated with dasatinib","volume":"59","author":"Buckner-Wolfson","year":"2024","journal-title":"Pediatr Neurosurg"},{"key":"2024062007514183800_nlae040-B85","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1158\/1078-0432.CCR-08-0168","article-title":"EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer","volume":"14","author":"Koivunen","year":"2008","journal-title":"Clin Cancer Res"},{"key":"2024062007514183800_nlae040-B86","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00401-018-1820-4","article-title":"Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway","volume":"135","author":"Pekmezci","year":"2018","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B87","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.humpath.2018.11.028","article-title":"Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum","volume":"86","author":"Choi","year":"2019","journal-title":"Hum Pathol"},{"key":"2024062007514183800_nlae040-B88","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00401-014-1264-4","article-title":"Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-kappaB signaling pathway","volume":"127","author":"Pietsch","year":"2014","journal-title":"Acta Neuropathol"},{"key":"2024062007514183800_nlae040-B89","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11327","article-title":"Subgroup-specific structural variation across 1,000 medulloblastoma genomes","volume":"488","author":"Northcott","year":"2012","journal-title":"Nature"},{"key":"2024062007514183800_nlae040-B90","doi-asserted-by":"crossref","first-page":"a014308","DOI":"10.1101\/cshperspect.a014308","article-title":"Role of MYC in medulloblastoma","volume":"3","author":"Roussel","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2024062007514183800_nlae040-B91","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3389\/fonc.2020.01290","article-title":"Mechanisms of cancer resistance to immunotherapy","volume":"10","author":"Bai","year":"2020","journal-title":"Front Oncol"},{"key":"2024062007514183800_nlae040-B92","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, adaptive, and acquired resistance to cancer immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"key":"2024062007514183800_nlae040-B93","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/1078-0432.CCR-21-2664","article-title":"Infigratinib in patients with recurrent gliomas and FGFR alterations: A multicenter phase II study","volume":"28","author":"Lassman","year":"2022","journal-title":"Clin Cancer Res"},{"key":"2024062007514183800_nlae040-B94","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1470-2045(23)00275-9","article-title":"Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): An international, single-arm, phase 2 study","volume":"24","author":"Pant","year":"2023","journal-title":"Lancet Oncol"},{"key":"2024062007514183800_nlae040-B95","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1158\/2159-8290.CD-16-1000","article-title":"Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive cholangiocarcinoma","volume":"7","author":"Goyal","year":"2017","journal-title":"Cancer Discov"},{"key":"2024062007514183800_nlae040-B96","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jnu.12000","article-title":"Ethical, legal, and social issues in the translation of genomics into health care","volume":"45","author":"Badzek","year":"2013","journal-title":"J Nurs Scholarsh"},{"key":"2024062007514183800_nlae040-B97","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/jamia\/ocw055","article-title":"Health informatics and analytics\u2014building a program to integrate business analytics across clinical and administrative disciplines","volume":"23","author":"Tremblay","year":"2016","journal-title":"J Am Med Inform Assoc"},{"key":"2024062007514183800_nlae040-B98","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1017\/S026646231800048X","article-title":"Evidence required by health technology assessment and reimbursement bodies evaluating diagnostic or prognostic algorithms that include omics data","volume":"34","author":"Barna","year":"2018","journal-title":"Int J Technol Assess Health Care"},{"key":"2024062007514183800_nlae040-B99","first-page":"624","article-title":"Insurance risk classification in an era of genomics: Is a rational discrimination policy rational?","volume":"96","author":"Prince","year":"2017","journal-title":"Neb Law Rev"},{"key":"2024062007514183800_nlae040-B100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41596-019-0251-6","article-title":"Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data","volume":"15","author":"Maros","year":"2020","journal-title":"Nat Protoc"},{"key":"2024062007514183800_nlae040-B101","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1038\/s41598-022-12699-z","article-title":"Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma","volume":"12","author":"Fathi Kazerooni","year":"2022","journal-title":"Sci Rep"},{"key":"2024062007514183800_nlae040-B102","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00428-011-1179-6","article-title":"Personalized cancer medicine and the future of pathology","volume":"460","author":"Moch","year":"2012","journal-title":"Virchows Arch"},{"key":"2024062007514183800_nlae040-B103","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13023-020-01556-9","article-title":"Health technology assessment and reimbursement policy for oncology orphan drugs in Central and Eastern Europe","volume":"15","author":"Malinowski","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"2024062007514183800_nlae040-B104","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1177\/19322968221121660","article-title":"The German fast track toward reimbursement of Digital Health Applications (DiGA): Opportunities and challenges for manufacturers, healthcare providers, and people with diabetes","volume":"18","author":"Schliess","year":"2022","journal-title":"J Diabetes Sci Technol"},{"key":"2024062007514183800_nlae040-B105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3414\/ME11-02-0048","article-title":"Costs of cloud computing for a biometry department. A case study","volume":"52","author":"Knaus","year":"2013","journal-title":"Methods Inf Med"},{"key":"2024062007514183800_nlae040-B106","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/2229-516X.173982","article-title":"The post-analytical phase of histopathology practice: Storage, retention and use of human tissue specimens","volume":"6","author":"Kapila","year":"2016","journal-title":"Int J Appl Basic Med Res"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/83\/7\/567\/58269740\/nlae040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/83\/7\/567\/58269740\/nlae040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:55:35Z","timestamp":1718870135000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/83\/7\/567\/7687644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":106,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,6,4]]},"published-print":{"date-parts":[[2024,6,20]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlae040","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"type":"print","value":"0022-3069"},{"type":"electronic","value":"1554-6578"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,6,4]]}}}