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However, extrapolation of these findings to a clinical context is problematic owing to the considerable differences often seen between in vivo findings in humans versus rodents. Therefore, we investigated whether the muscle regenerative behavior of hMuStem cells is maintained in a clinically relevant transplantation context. Human MuStem cells were intramuscularly administered by high-density microinjection matrices into nonhuman primates receiving tacrolimus-based immunosuppression thereby reproducing the protocol that has so far produced the best results in clinical trials of cell therapy in myopathies. Four and 9\u2009weeks after administration, histological analysis of cell injection sites revealed large numbers of hMuStem cell-derived nuclei in all cases. Most graft-derived nuclei were distributed in small myofiber groups in which no signs of a specific immune response were observed. Importantly, hMuStem cells contributed to simian tissue repair by fusing mainly with host myofibers, demonstrating their capacity for myofiber regeneration in this model. Together, these findings obtained in a valid preclinical model provide new insights supporting the potential of hMuStem cells in future cell therapies for muscle diseases.<\/jats:p>","DOI":"10.1093\/jnen\/nlae044","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T11:22:05Z","timestamp":1715858525000},"page":"684-694","source":"Crossref","is-referenced-by-count":2,"title":["Human MuStem cells are competent to fuse with nonhuman primate myofibers in a clinically relevant transplantation context: A proof-of-concept study"],"prefix":"10.1093","volume":"83","author":[{"given":"Marine","family":"Charrier","sequence":"first","affiliation":[{"name":"Oniris, INRAE, PAnTher , Nantes, France"},{"name":"L\u2019institut du Thorax, INSERM, CNRS, UNIV Nantes , Nantes, France"},{"name":"Nantes Universit\u00e9 , Nantes, 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P","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Axe Neurosciences, Research Center of the CHU de Quebec\u2014CHUL and Department of Molecular Medicine, School of Medicine, Laval University , Quebec, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-0082","authenticated-orcid":false,"given":"Daniel","family":"Skuk","sequence":"additional","affiliation":[{"name":"Axe Neurosciences, Research Center of the CHU de Quebec\u2014CHUL and Department of Molecular Medicine, School of Medicine, Laval University , Quebec, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-1735","authenticated-orcid":false,"given":"Karl","family":"Rouger","sequence":"additional","affiliation":[{"name":"Oniris, INRAE, PAnTher , Nantes, 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