{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:16:59Z","timestamp":1788297419492,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Henan Province Science and Technology","award":["222102110348"],"award-info":[{"award-number":["222102110348"]}]},{"name":"Henan Province Science and Technology","award":["232102310480"],"award-info":[{"award-number":["232102310480"]}]},{"name":"Xinxiang City Science and Technology","award":["GG2020054"],"award-info":[{"award-number":["GG2020054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic hyperglycemia can result in damage to the hippocampus and dysfunction of the blood-brain barrier (BBB), potentially leading to neurological disorders. This study examined the histological structure of the hippocampus and the expression of critical genes associated with the BBB at 2 early stage time points in a streptozotocin-induced diabetes mellitus (DM) mouse model. Routine histology revealed vascular congestion and dilation of Virchow-Robin spaces in the hippocampal CA1 region of the DM group. Neuronal alterations included rounding and swelling and reduction in Nissl bodies and increased apoptosis. Compared to the control group, TJP1 mRNA expression in the DM group was significantly lower (P\u2009&amp;lt;\u2009.05 or P\u2009&amp;lt;\u2009.01), while mRNA levels of JAM3, TJP3, CLDN5, CLDN3, and OCLN initially increased and then decreased. At 7, 14, and 21\u2009days, mRNA levels of the receptor for advanced glycation end products (AGER) were greater in the DM group than in the control group (P\u2009&amp;lt;\u2009.05 or P\u2009&amp;lt;\u2009.01). These findings indicate that early-stage diabetes may cause structural and functional impairments in hippocampal CA1 in mice. These abnormalities may parallel alterations in the expression of key BBB tight junction molecules and elevated AGER expression in early DM patients.<\/jats:p>","DOI":"10.1093\/jnen\/nlae056","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T14:43:29Z","timestamp":1718376209000},"page":"763-771","source":"Crossref","is-referenced-by-count":4,"title":["Dynamic changes in key factors of the blood-brain barrier in early diabetic mice"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-8116","authenticated-orcid":false,"given":"Zhi-yong","family":"Xu","sequence":"first","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-xian","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-min","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"The 83rd Army Group Hospital of the Chinese People\u2019s Liberation Army , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-you","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Le","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-peng","family":"Han","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-xue","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Shanxi Agricultural University , Taigu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"issue":"7","key":"2024082007511550000_nlae056-B1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"2024082007511550000_nlae056-B2","doi-asserted-by":"crossref","first-page":"5514175","DOI":"10.1155\/2021\/5514175","article-title":"Huang-Pu-Tong-Qiao formula ameliorates the hippocampus apoptosis in diabetic cognitive dysfunction mice by activating CREB\/BDNF\/TrkB signaling pathway","volume":"2021","author":"Ye","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"2024082007511550000_nlae056-B3","first-page":"125","article-title":"Diabetes mellitus and blood-brain barrier dysfunction: an overview","volume":"2","author":"Prasad","year":"2014","journal-title":"J Pharmacovigil"},{"key":"2024082007511550000_nlae056-B4","doi-asserted-by":"crossref","first-page":"8073516","DOI":"10.1155\/2020\/8073516","article-title":"Role of mitochondrial stress protein HSP60 in diabetes-induced neuroinflammation","volume":"2020","author":"Liyanagamage","year":"2020","journal-title":"Mediators Inflamm"},{"key":"2024082007511550000_nlae056-B5","doi-asserted-by":"crossref","first-page":"6564585","DOI":"10.1155\/2021\/6564585","article-title":"Blood-brain barrier overview: structural and functional correlation","volume":"2021","author":"Alahmari","year":"2021","journal-title":"Neural Plast"},{"issue":"6","key":"2024082007511550000_nlae056-B6","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","article-title":"The blood-brain barrier in aging and neurodegeneration","volume":"27","author":"Knox","year":"2022","journal-title":"Mol Psychiatry"},{"issue":"3","key":"2024082007511550000_nlae056-B7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"12","key":"2024082007511550000_nlae056-B8","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat Med"},{"issue":"4","key":"2024082007511550000_nlae056-B9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11481-017-9752-7","article-title":"Blood brain barrier injury in diabetes: unrecognized effects on brain and cognition","volume":"12","author":"Bogush","year":"2017","journal-title":"J Neuroimmune Pharmacol"},{"issue":"3","key":"2024082007511550000_nlae056-B10","doi-asserted-by":"crossref","first-page":"1926190","DOI":"10.1080\/21688370.2021.1926190","article-title":"The blood-brain and gut-vascular barriers: from the perspective of claudins","volume":"9","author":"Scalise","year":"2021","journal-title":"Tissue Barriers"},{"issue":"4","key":"2024082007511550000_nlae056-B11","doi-asserted-by":"crossref","first-page":"e20190062","DOI":"10.1084\/jem.20190062","article-title":"The blood-brain barrier in health and disease: important unanswered questions","volume":"217","author":"Profaci","year":"2020","journal-title":"J Exp Med"},{"issue":"3","key":"2024082007511550000_nlae056-B12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.200302070","article-title":"Size-selective loosening of the blood-brain barrier in Claudin-5-deficient mice","volume":"161","author":"Nitta","year":"2003","journal-title":"J Cell Biol"},{"issue":"3","key":"2024082007511550000_nlae056-B13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"3","key":"2024082007511550000_nlae056-B14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/bc.bc_29_20","article-title":"Occludin regulation of blood-brain barrier and potential therapeutic target in ischemic stroke","volume":"6","author":"Yuan","year":"2020","journal-title":"Brain Circ"},{"issue":"1_suppl","key":"2024082007511550000_nlae056-B15","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1177\/0271678X20951995","article-title":"Regulation of blood-brain barrier integrity by microglia in health and disease: a therapeutic opportunity","volume":"40","author":"Ronaldson","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"2024082007511550000_nlae056-B16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s12975-018-0683-2","article-title":"Hypoxia-induced microRNA-212\/132 alter blood-brain barrier integrity through inhibition of tight junction-associated proteins in human and mouse brain microvascular endothelial cells","volume":"10","author":"Burek","year":"2019","journal-title":"Transl Stroke Res"},{"issue":"1","key":"2024082007511550000_nlae056-B17","doi-asserted-by":"crossref","first-page":"1840913","DOI":"10.1080\/21688370.2020.1840913","article-title":"Basic physiology of the blood-brain barrier in health and disease: a brief overview","volume":"9","author":"Kaya","year":"2021","journal-title":"Tissue Barriers"},{"issue":"7","key":"2024082007511550000_nlae056-B18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4155\/fmc.12.51","article-title":"Is AGER still a therapeutic target for Alzheimer's disease?","volume":"4","author":"Deane","year":"2012","journal-title":"Future Med Chem"},{"issue":"4","key":"2024082007511550000_nlae056-B19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3390\/biomedicines11041131","article-title":"AGER inhibitors in neurodegenerative diseases","volume":"11","author":"Reddy","year":"2023","journal-title":"Biomedicines"},{"issue":"5","key":"2024082007511550000_nlae056-B20","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbadis.2016.04.017","article-title":"Common neurodegenerative pathways in obesity, diabetes, and Alzheimer\u2019s disease","volume":"1863","author":"Pugazhenthi","year":"2017","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2024082007511550000_nlae056-B21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4093\/dmj.2021.0146","article-title":"Glial and vascular cell regulation of the blood-brain barrier in diabetes","volume":"46","author":"Li","year":"2022","journal-title":"Diabetes Metab J"},{"issue":"1","key":"2024082007511550000_nlae056-B22","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1080\/21655979.2021.1948950","article-title":"Azilsartan protects against hyperglycemia-induced hyperpermeability of the blood-brain barrier","volume":"12","author":"Han","year":"2021","journal-title":"Bioengineered"},{"issue":"5","key":"2024082007511550000_nlae056-B23","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.3390\/nu12082383","article-title":"Ginseng extracts, GS-KG9 and GS-E3D, prevent blood-brain barrier disruption and thereby inhibit apoptotic cell death of hippocampal neurons in streptozotocin-induced diabetic rats","volume":"13","author":"Lee","year":"2020","journal-title":"Nutrients"},{"issue":"26","key":"2024082007511550000_nlae056-B24","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1523\/JNEUROSCI.6102-11.2012","article-title":"A\u03b21-42-AGER interaction disrupts tight junctions of the blood-brain barrier via Ca2+-calcineurin signaling","volume":"32","author":"Kook","year":"2012","journal-title":"J Neurosci"},{"key":"2024082007511550000_nlae056-B25","first-page":"61","article-title":"Study on the normal reference value of fasting blood glucose in ICR mice","volume":"1)","author":"Chen","year":"2004","journal-title":"J Health Toxicol"},{"issue":"1","key":"2024082007511550000_nlae056-B26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4162\/nrp.2016.10.1.33","article-title":"Similarities and differences between alpha-tocopherol and gamma-tocopherol in amelioration of inflammation, oxidative stress and pre-fibrosis in hyperglycemia induced acute kidney inflammation","volume":"10","author":"Shin","year":"2016","journal-title":"Nutr Res Pract"},{"issue":"19","key":"2024082007511550000_nlae056-B27","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.3390\/molecules28196775","article-title":"Oral glucose tolerance test (OGTT) evidence for the postprandial anti-hyperglycemic property of Salacca zalacca (Gaertn.) voss seed extract","volume":"28","author":"Sato","year":"2023","journal-title":"Molecules"},{"key":"2024082007511550000_nlae056-B28","doi-asserted-by":"crossref","first-page":"9951463","DOI":"10.1155\/2021\/9951463","article-title":"Polyethylene glycol loxenatide (PEX-168) reduces body weight and blood glucose in simple obese mice","volume":"2021","author":"Wu","year":"2021","journal-title":"Int J Endocrinol"},{"key":"2024082007511550000_nlae056-B29","doi-asserted-by":"crossref","first-page":"7543049","DOI":"10.1155\/2019\/7543049","article-title":"Determination of electroacupuncture effects on circRNAs in plasma exosomes in diabetic mice: an RNA-sequencing approach","volume":"2019","author":"Shou","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"issue":"7","key":"2024082007511550000_nlae056-B30","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/ptr.2734","article-title":"Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats","volume":"23","author":"Xue","year":"2009","journal-title":"Phytother Res"},{"issue":"8","key":"2024082007511550000_nlae056-B31","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.neubiorev.2013.03.010","article-title":"Effects of diabetes on hippocampal neurogenesis: links to cognition and depression","volume":"37","author":"Ho","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"2024082007511550000_nlae056-B32","doi-asserted-by":"crossref","first-page":"974690","DOI":"10.3389\/fnagi.2022.974690","article-title":"Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice","volume":"14","author":"Nan","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"14","key":"2024082007511550000_nlae056-B33","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.18632\/aging.103435","article-title":"Lowered levels of nicotinic acetylcholine receptors and elevated apoptosis in the hippocampus of brains from patients with type 2 diabetes mellitus and db\/db mice","volume":"12","author":"Xu","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"2024082007511550000_nlae056-B34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1460-9568.2005.04205.x","article-title":"Diabetes mellitus concomitantly facilitates the induction of long-term depression and inhibits that of long-term potentiation in hippocampus","volume":"22","author":"Artola","year":"2005","journal-title":"Eur J Neurosci"},{"issue":"1","key":"2024082007511550000_nlae056-B35","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1038\/s41598-020-64349-x","article-title":"Hyperglycemia and advanced glycation end products disrupt BBB and promote Occludin and Claudin-5 protein secretion on extracellular microvesicles","volume":"10","author":"Rom","year":"2020","journal-title":"Sci Rep"},{"issue":"11","key":"2024082007511550000_nlae056-B36","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1074\/jbc.M113.531012","article-title":"Claudin-3 and Claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments","volume":"289","author":"Rossa","year":"2014","journal-title":"J Biol Chem"},{"key":"2024082007511550000_nlae056-B37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","article-title":"Development and cell biology of the blood-brain barrier","volume":"35","author":"Langen","year":"2019","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"2024082007511550000_nlae056-B38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"2024082007511550000_nlae056-B39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2024082007511550000_nlae056-B40","doi-asserted-by":"crossref","first-page":"C343","DOI":"10.1152\/ajpcell.00095.2018","article-title":"Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection","volume":"315","author":"Abdullahi","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"2024082007511550000_nlae056-B41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12974-019-1495-3","article-title":"HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice","volume":"16","author":"Zhao","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"3","key":"2024082007511550000_nlae056-B42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3892\/ijmm.2021.5011","article-title":"Selenium attenuates ischemia\/reperfusion injury-induced damage to the blood-brain barrier in hyperglycemia through PI3K\/AKT\/mTOR pathway-mediated autophagy inhibition","volume":"48","author":"Yang","year":"2021","journal-title":"Int J Mol Med"},{"issue":"11","key":"2024082007511550000_nlae056-B43","doi-asserted-by":"crossref","first-page":"e0277457","DOI":"10.1371\/journal.pone.0277457","article-title":"Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical\/noncanonical Wnt\/\u03b2-catenin signaling","volume":"17","author":"Muneeb","year":"2022","journal-title":"PLoS One"},{"key":"2024082007511550000_nlae056-B44","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.neuroscience.2012.07.018","article-title":"Tissue plasminogen activator treatment of stroke in type-1 diabetes rats","volume":"222","author":"Ning","year":"2012","journal-title":"Neuroscience"},{"issue":"1","key":"2024082007511550000_nlae056-B45","doi-asserted-by":"crossref","first-page":"e13074","DOI":"10.1111\/jne.13074","article-title":"Breakdown of the blood-brain barrier: a mediator of increased Alzheimer\u2019s risk in patients with metabolic disorders?","volume":"34","author":"Frank","year":"2022","journal-title":"J Neuroendocrinol"},{"issue":"12","key":"2024082007511550000_nlae056-B46","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.3390\/ijms241210069","article-title":"Effects of diabetes mellitus-related dysglycemia on the functions of blood-brain barrier and the risk of dementia","volume":"24","author":"W\u0105troba","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2024082007511550000_nlae056-B47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/00207454.2013.825258","article-title":"The potential mechanisms of A\u03b2-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease","volume":"124","author":"Wan","year":"2014","journal-title":"Int J Neurosci"},{"issue":"4","key":"2024082007511550000_nlae056-B48","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/jnr.23511","article-title":"Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats","volume":"93","author":"Sun","year":"2015","journal-title":"J Neurosci Res"},{"issue":"4","key":"2024082007511550000_nlae056-B49","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","article-title":"Advanced glycation end products and diabetes mellitus: mechanisms and perspectives","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"issue":"3","key":"2024082007511550000_nlae056-B50","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.3390\/ijms24032894","article-title":"The Potential Influence of Advanced Glycation End Products and (s)RAGE in Rheumatic Diseases","volume":"24","author":"Delrue","year":"2023","journal-title":"IJMS"},{"issue":"7","key":"2024082007511550000_nlae056-B51","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1182\/blood-2002-05-1300","article-title":"Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells","volume":"101","author":"Fiuza","year":"2003","journal-title":"Blood"},{"key":"2024082007511550000_nlae056-B52","doi-asserted-by":"crossref","first-page":"1155175","DOI":"10.3389\/fnmol.2023.1155175","article-title":"AGE-AGER axis culminates into multiple pathogenic processes: a central road to neurodegeneration","volume":"16","author":"Bhattacharya","year":"2023","journal-title":"Front Mol Neurosci"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/83\/9\/763\/58813148\/nlae056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/83\/9\/763\/58813148\/nlae056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T09:55:00Z","timestamp":1724147700000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/83\/9\/763\/7693392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":52,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,6,14]]},"published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlae056","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,6,14]]}}}