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In the final model, high ABCA7 levels in the parietal cortex increased the odds of remaining cognitively healthy (ie, in stages 0\/I) versus experiencing AD onset (ie, progressing to stages II-V) in the 61-80 age segment (OR\u2009=\u20092.87, adj 95% CI\u2009=\u20091.41-7.86, adj P\u2009=\u2009.007, n\u2009=\u2009109), after controlling for APOE and other covariates. No ABCA7-AD association was found in the 81-98 age segment (n\u2009=\u2009113). Parietal ABCA7 levels in 61-80-year-old with stages II-V were very low, even significantly lower than in 81-98-year-old with stages II-V. ABCA7 levels in the prefrontal cortex and hippocampus predicted AD onset in the 61-80 age segment after adjustment for APOE. ABCA7 levels were also the lowest in 61-80-year-old with frequent neuritic plaques. Thus, very low ABCA7 levels in the cerebrum are associated with AD onset in the 7th-8th decade of life.<\/jats:p>","DOI":"10.1093\/jnen\/nlae060","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:19:34Z","timestamp":1718896774000},"page":"808-821","source":"Crossref","is-referenced-by-count":2,"title":["Very low levels of ABCA7 in the cerebrum and Alzheimer\u2019s disease onset between the ages of 60 and 80 independently of <i>APOE<\/i>"],"prefix":"10.1093","volume":"83","author":[{"given":"Viktor","family":"Garliyev","sequence":"first","affiliation":[{"name":"Alzheimer\u2019s Center at Temple, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University , Philadelphia, PA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A","family":"Lyssenko","sequence":"additional","affiliation":[{"name":"Office of Institutional Research & Analysis, University of Pennsylvania , Philadelphia, PA, United 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