{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:51:31Z","timestamp":1787241091138,"version":"build-2736575974"},"reference-count":155,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Health Administration"},{"DOI":"10.13039\/100006380","name":"Rehabilitation Research & Development Service","doi-asserted-by":"publisher","award":["IK2RX002702"],"award-info":[{"award-number":["IK2RX002702"]}],"id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Existing diffusion tensor imaging (DTI) studies of neurological injury following high-level blast exposure (hlBE) in military personnel have produced widely variable results. This is potentially due to prior studies often not considering the quantity and\/or recency of hlBE, as well as co-morbidity with non-blast head trauma (nbHT). Herein, we compare commonly used DTI metrics: fractional anisotropy and mean, axial, and radial diffusivity, in Veterans with and without history of hlBE and\/or nbHT. We use both the traditional method of dividing participants into 2 equally weighted groups and an alternative method wherein each participant is weighted by quantity and recency of hlBE and\/or nbHT. While no differences were detected using the traditional method, the alternative method revealed diffuse and extensive changes in all DTI metrics. These effects were quantified within 43 anatomically defined white matter tracts, which identified the forceps minor, middle corpus callosum, acoustic and optic radiations, fornix, uncinate, inferior fronto-occipital and inferior longitudinal fasciculi, and cingulum, as the pathways most affected by hlBE and nbHT. Moreover, additive effects of aging were present in many of the same tracts suggesting that these neuroanatomical effects may compound with age.<\/jats:p>","DOI":"10.1093\/jnen\/nlae069","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T16:48:43Z","timestamp":1721926123000},"page":"853-869","source":"Crossref","is-referenced-by-count":3,"title":["Additive effects of mild head trauma, blast exposure, and aging within white matter tracts: A novel Diffusion Tensor Imaging analysis approach"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-9731","authenticated-orcid":false,"given":"Oren","family":"Poliva","sequence":"first","affiliation":[{"name":"VA Loma Linda Healthcare System , Loma Linda, CA,","place":["United States"]},{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Loma Linda University Medical Center , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herrera","sequence":"additional","affiliation":[{"name":"VA Loma Linda Healthcare System , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Sugai","sequence":"additional","affiliation":[{"name":"VA Loma Linda Healthcare System , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Whittle","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System , Portland, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie R","family":"Leek","sequence":"additional","affiliation":[{"name":"VA Loma Linda Healthcare System , Loma Linda, CA,","place":["United States"]},{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Loma Linda University Medical Center , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Loma Linda University Medical Center , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Holshouser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Loma Linda University Medical Center , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Yi","sequence":"additional","affiliation":[{"name":"VA Loma Linda Healthcare System , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H","family":"Venezia","sequence":"additional","affiliation":[{"name":"VA Loma Linda Healthcare System , Loma Linda, CA,","place":["United States"]},{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Loma Linda University Medical Center , Loma Linda, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"issue":"12","key":"2025072420020717600_nlae069-B1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/aje\/kwn068","article-title":"Understanding sequelae of injury mechanisms and mild traumatic brain injury incurred during the conflicts in Iraq and Afghanistan: persistent postconcussive symptoms and posttraumatic stress disorder","volume":"167","author":"Schneiderman","year":"2008","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2025072420020717600_nlae069-B2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/HTR.0b013e31819581d8","article-title":"Traumatic brain injury screening: preliminary findings in a US Army Brigade Combat 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