{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:26:42Z","timestamp":1789007202393,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J01260"],"award-info":[{"award-number":["2021J01260"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Second Affiliated Hospital of Fujian Medical University","award":["2202BD1706"],"award-info":[{"award-number":["2202BD1706"]}]},{"name":"Second Affiliated Hospital of Fujian Medical University","award":["2202BD1707"],"award-info":[{"award-number":["2202BD1707"]}]},{"name":"Second Affiliated Hospital of Fujian Medical University","award":["2202BD1709"],"award-info":[{"award-number":["2202BD1709"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Omega-3 polyunsaturated fatty acids (\u03c9-3 PUFAs) attenuate inflammatory responses in the central nervous system, leading to neuroprotective effects. Inhibition of histone deacetylase 3 (HDAC3) has neuroprotective effects after spinal cord injury (SCI) through the SIRT1 pathway, but the pathophysiological mechanisms of SCI are complex and the interactions between \u03c9-3 PUFAs and organelles remain largely unknown. This study aimed to investigate the effect of \u03c9-3 PUFAs on endoplasmic reticulum (ER) stress-induced neuroinflammation through the HDAC3\/peroxisome proliferator-activated receptor-\u03b3 coactivator (PGC)-1\u0251 pathway after SCI. To this end, a contusion-induced SCI rat model was established to evaluate the effects of \u03c9-3 PUFAs on ER stress-mediated inflammation in SCI. ER stress was rapidly induced in spinal cord lesions after SCI and was significantly reduced after \u03c9-3 PUFA treatment. Consistent with reduced ER stress, HDAC3 expression levels and inflammatory responses were decreased, and PGC-1\u0251 expression levels were increased after SCI. We found that \u03c9-3 PUFA treatment attenuated ER stress through HDAC3 inhibition, thereby reducing SCI-induced inflammation. Taken together, these results suggest a role for \u03c9-3 PUFA in protecting against SCI-induced neuroinflammation and promoting neurological functional recovery by regulating the histone deacetylase 3\/ peroxisome proliferator-activated receptor-\u03b3 coactivator\u00a0pathway.<\/jats:p>","DOI":"10.1093\/jnen\/nlae094","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T20:11:19Z","timestamp":1724789479000},"page":"939-950","source":"Crossref","is-referenced-by-count":7,"title":["Omega-3 polyunsaturated fatty acids alleviate endoplasmic reticulum stress-induced neuroinflammation by protecting against traumatic spinal cord injury through the histone deacetylase 3\/ peroxisome proliferator-activated receptor-\u03b3 coactivator pathway"],"prefix":"10.1093","volume":"83","author":[{"given":"Lijiang","family":"He","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Second Affiliated Hospital of Fujian Medical University , Quanzhou, Fujian Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Nursing Faculty, Quanzhou Medical College , Quanzhou, Fujian Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunrong","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Affiliated Hospital of Fujian Medical University , Quanzhou, Fujian Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Affiliated Hospital of Fujian Medical University , Quanzhou, Fujian Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second 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