{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:20:29Z","timestamp":1788373229467,"version":"build-2803163510"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ecole de l\u2019Inserm Liliane Bettencourt Programme"},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AFM-T\u00e9l\u00e9thon, Fil\u00e8ere neuromusculaire fran\u00e7aise"},{"DOI":"10.13039\/501100010288","name":"Foundation for the Development of Internal Medicine in Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Idiopathic inflammatory myopathies (IIM) are rare, acquired muscle diseases; their diagnosis of is based on clinical, serological, and histological criteria. MHC-I-positive immunostaining, although non-specific, is used as a marker for IIM diagnosis; however, the significance of major histocompatibility complex (MHC)-II immunostaining in IIM remains debated. We investigated patterns of MHC-II immunostaining in myofibers and capillaries in muscle biopsies from 103 patients with dermatomyositis ([DM], n\u2009=\u200931), inclusion body myositis ([IBM], n\u2009=\u200924), anti-synthetase syndrome ([ASyS], n\u2009=\u200910), immune-mediated necrotizing myopathy ([IMNM], n\u2009=\u200918), or overlap myositis ([OM], n\u2009=\u200920). MHC-II immunostaining of myofibers was abnormal in 63\/103 of patients (61%) but the patterns differed according to the IIM subgroup. They were diffuse in IBM (96%), negative in IMNM (83%), perifascicular in ASyS (70%), negative (61%) or perifascicular (32%) in DM, and either clustered (40%), perifascicular (30%), or diffuse heterogeneous (15%) in OM. Capillary MHC-II immunostaining also identified quantitative (capillary dropout, n\u2009=\u200947\/88, 53%) and qualitative abnormalities, that is, architectural abnormalities, including dilated and leaky capillaries, (n\u2009=\u200979\/98, 81%) in all IIM subgroups. Thus, MHC-II myofiber expression patterns allow distinguishing among IIM subgroups. We suggest the addition of MHC-II immunostaining to routine histological panels for IIM diagnosis.<\/jats:p>","DOI":"10.1093\/jnen\/nlae098","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:10:34Z","timestamp":1726503034000},"page":"1060-1075","source":"Crossref","is-referenced-by-count":11,"title":["Contribution of major histocompatibility complex class II immunostaining in distinguishing idiopathic inflammatory myopathy subgroups: A histopathological cohort study"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-0227","authenticated-orcid":false,"given":"Lola E R","family":"Lessard","sequence":"first","affiliation":[{"name":"Service d\u2019Electroneuromyographie et de pathologies neuromusculaires, H\u00f4pital Neurologique, GHE, Hospices Civils de Lyon , Lyon,","place":["France"]},{"name":"Institut NeuroMyoG\u00e8ne, Unit\u00e9 Physiopathologie et G\u00e9n\u00e9tique du Neurone et du Muscle, CNRS UMR 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