{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:55:35Z","timestamp":1792266935744,"version":"4.4.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG078505"],"award-info":[{"award-number":["R21 AG078505"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020423","name":"Texas Alzheimer\u2019s Research and Care Consortium","doi-asserted-by":"crossref","award":["957581"],"award-info":[{"award-number":["957581"]}],"id":[{"id":"10.13039\/100020423","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020423","name":"Texas Alzheimer\u2019s Research and Care Consortium","doi-asserted-by":"crossref","award":["957607"],"award-info":[{"award-number":["957607"]}],"id":[{"id":"10.13039\/100020423","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R01 AG077472"],"award-info":[{"award-number":["R01 AG077472"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U24 AG072122"],"award-info":[{"award-number":["U24 AG072122"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, the presence of multiple comorbid neuropathologies is increasingly being recognized as a major contributor to the worldwide dementia burden. We analyzed 1051 subjects with specific combinations of isolated and mixed pathologies and conducted multivariate logistic regression analysis on a cohort of 4624 cases with mixed pathologies to systematically explore the independent cognitive contributions of each pathology. Alzheimer disease neuropathologic change and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) were both associated with a primary clinical diagnosis of Alzheimer disease (AD) and were characterized by an amnestic dementia phenotype, while only ADNC associated with logopenic variant primary progressive aphasia (PPA). In subjects with ADNC and comorbid LATE-NC, Lewy body disease, and\/or cerebrovascular disease, the clinical phenotype was usually diagnosed during life as \u201cProbable AD.\u201d Conversely, the combination of ADNC with frontotemporal lobar degeneration with TDP-43, progressive supranuclear palsy (PSP), or corticobasal degeneration (CBD) resulted in a mixed clinical picture, with variable features of amnestic dementia, PPA subtypes, behavioral variant FTD, PSP syndrome, and CBD syndrome. These findings elucidate the cumulative effects of mixed pathologies and provide insights into interactions between neurodegenerative pathologies contributing to a variety of clinical dementia presentations.<\/jats:p>","DOI":"10.1093\/jnen\/nlae134","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T05:51:57Z","timestamp":1733896317000},"page":"177-194","source":"Crossref","is-referenced-by-count":14,"title":["Unraveling the clinical\u2013pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer\u2019s Coordinating Center dataset"],"prefix":"10.1093","volume":"84","author":[{"given":"Satomi","family":"Hiya","sequence":"first","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United 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Alzheimer Center Amsterdam, Neuroscience, Vrije Universiteit Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitzi M","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cedars Sinai Medical Center , Los Angeles, CA,","place":["United States"]},{"name":"Department of Neurology, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Canbeldek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi S","family":"Kulumani Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel T","family":"Yokoda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Campbell","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia S","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles L","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center , Dallas, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center , Dallas, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Flores-Almazan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Crary","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United 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Loeb Center for Alzheimer\u2019s Disease, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United 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