{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:04:01Z","timestamp":1761649441653,"version":"3.40.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Paul H. Boerger Fund of the Delaware Community Foundation"},{"DOI":"10.13039\/100013429","name":"Delaware INBRE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["P20 GM103446"],"award-info":[{"award-number":["P20 GM103446"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centers of Biomedical Research Excellence","award":["5P20GM103653"],"award-info":[{"award-number":["5P20GM103653"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K08AG065463"],"award-info":[{"award-number":["K08AG065463"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24NS133945"],"award-info":[{"award-number":["U24NS133945"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["RF1AG072080","R01AG082118","P30AG066546"],"award-info":[{"award-number":["RF1AG072080","R01AG082118","P30AG066546"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Trans-active response DNA-binding protein-43 (TDP-43) is the major pathological protein in motor neuron disease and TDP-43 pathology has been described in the brains of up to 50% of patients with Alzheimer disease (AD). Hippocampal sclerosis of aging (HS-A), an age-related neuropathology characterized by severe neuronal loss and gliosis in CA1 and\/or subiculum, is found in \u223c80% of cases that are positive for phosphorylated TDP-43. HS-A is seen as a co-pathology in cases with AD, limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC), and frontotemporal degeneration. To understand the pathogenetic relationships between HS-A and LATE-NC, mice that selectively express human TDP-43 and TDP-43 with a defective nuclear localization signal (\u0394NLS) in the hippocampus, alone or in an APP\/PSEN1 background, were evaluated using histology, HALO software\u2019s object recognition algorithms, and protein expression assays. Twenty-four-month-old mice expressing cytosolic TDP-43 displayed marked neuronal loss and atrophy in the hippocampus, decreased \u03b2-amyloid plaque deposition and modulation of microglia and intermediate filament activation. TDP-43\u0394NLS-expressing mice survived to only \u223c24\u2009months of age whether or not they had an APP\/PSEN1 background. This HS-A-like model may provide insights into the pathogenesis of neurodegeneration seen in HS-A and in other TDP-43 proteinopathies.<\/jats:p>","DOI":"10.1093\/jnen\/nlae137","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T23:06:02Z","timestamp":1737932762000},"page":"293-304","source":"Crossref","is-referenced-by-count":1,"title":["Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan"],"prefix":"10.1093","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-7614","authenticated-orcid":false,"given":"Ashley J","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Delaware State University , Dover, DE,","place":["United States"]},{"name":"Delaware Center for Neuroscience Research , Dover, DE,","place":["United 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Biological Sciences, Delaware State University , Dover, DE,","place":["United States"]},{"name":"Delaware Center for Neuroscience Research , Dover, DE,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephani A","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Delaware State University , Dover, DE,","place":["United States"]},{"name":"Delaware Center for Neuroscience Research , Dover, DE,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-1186","authenticated-orcid":false,"given":"Kaouther","family":"Ajroud","sequence":"additional","affiliation":[{"name":"Bigg\u2019s Institute for Alzheimer\u2019s Disease and Dementia, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Department of Pathology, University of Texas Health San Antonio , San Antonio, TX,","place":["United 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States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6865-3097","authenticated-orcid":false,"given":"Rachel","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Bigg\u2019s Institute for Alzheimer\u2019s Disease and Dementia, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Department of Pathology, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-2618","authenticated-orcid":false,"given":"Margaret E","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Bigg\u2019s Institute for Alzheimer\u2019s Disease and Dementia, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Department of Pathology, University of Texas Health San Antonio , San Antonio, TX,","place":["United 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