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Over the past 40\u2009years, AIS research has relied on a perceived linear relationship between lesion volumes and neurological deficit. Here, we found that these variables do not show a relationship in a mouse model of AIS. Acute ischemic stroke was induced by transient (60\u2009minutes) intraluminal microfilament occlusion of the middle cerebral artery in 15 male isoflurane (0.8%-1%)-anesthetized mice. Acute ischemic stroke-induced sensorimotor deficits were assessed daily for 72\u2009hours using the Garcia Neuroscore Scale (GNS). Lesion size was estimated 72\u2009hours after AIS using a rodent MRI system. Lesion sizes ranged from 17 to 130 mm3. In 3\/15 mice (atypical cases: lesion &amp;lt;30 mm3 and GNS &amp;lt;11), small infarcts (14.6\u2009\u00b1\u20096.2 vs 51.7\u2009\u00b1\u200919.9 mm3, atypical vs typical) were associated with low GNS values at 72\u2009hours (9\u2009\u00b1\u20092 vs 11\u2009\u00b1\u20092 pts; atypical vs typical). Consequently, we found no relationship between lesion size and GNS in this AIS model (R\u2009=\u20090.058). These results suggest that lesion size is not a reliable predictor of neurological outcome in AIS models.<\/jats:p>","DOI":"10.1093\/jnen\/nlaf046","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T12:18:31Z","timestamp":1745497111000},"page":"771-779","source":"Crossref","is-referenced-by-count":5,"title":["The paradoxical relationship of sensorimotor deficit and lesion volume in acute ischemic stroke"],"prefix":"10.1093","volume":"84","author":[{"given":"R\u00e9ka","family":"T\u00f3th","sequence":"first","affiliation":[{"name":"HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd , Szeged,","place":["Hungary"]},{"name":"Department of Cell Biology and Molecular Medicine, University of Szeged , Szeged,","place":["Hungary"]},{"name":"Department of Radiology, University of Szeged , Szeged,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoletta","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Szeged , Szeged,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"T\u00f6rteli","sequence":"additional","affiliation":[{"name":"HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd , Szeged,","place":["Hungary"]},{"name":"Department of Cell Biology and Molecular Medicine, University of Szeged , Szeged,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"HCEMM-SU In Vivo Imaging Advanced Core Facility , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriszti\u00e1n","family":"Szigeti","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domokos","family":"M\u00e1th\u00e9","sequence":"additional","affiliation":[{"name":"HCEMM-SU In Vivo Imaging Advanced Core Facility , Budapest,","place":["Hungary"]},{"name":"Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s Zs","family":"Kincses","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Szeged , Szeged,","place":["Hungary"]},{"name":"Department of Neurology, University of Szeged , Szeged,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-3208","authenticated-orcid":false,"given":"\u00c1kos","family":"Menyh\u00e1rt","sequence":"additional","affiliation":[{"name":"HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd , Szeged,","place":["Hungary"]},{"name":"Department of Cell Biology and Molecular Medicine, University of Szeged , Szeged,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Farkas","sequence":"additional","affiliation":[{"name":"HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM 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