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Forty-seven consecutive donor brains from the Late Effects of TBI Project underwent comprehensive neuropathologic evaluation. Seven (14.9%; median age, seventh decade) had CTE-NC, defined as perivascular neuronal tau at the depth of sulcus. Four had 4 \u201clow\u201d CTE-NC burden, 1 \u201chigh,\u201d and 2 \u201cindeterminate.\u201d Ex vivo neuroimaging in 5 facilitated histological sampling of subtle changes otherwise likely to be overlooked. Five of the 7 CTE-NC donors reportedly had substantial RHI exposure: football (n\u2009=\u20093), boxing (n\u2009=\u20091), military and interpersonal violence (n\u2009=\u20091), and child abuse (n\u2009=\u20091). One CTE-NC case had no known RHI exposure but had 2 severe iTBIs sustained 30 and 3\u2009years prior to death. Donors without CTE-NC had variable patterns of head trauma: RHI exposure (college football, n\u2009=\u20094), some RHI (n\u2009=\u200921, 17 of whom also had \u22651 iTBI), and \u22651 iTBI but no RHI (n\u2009=\u200915). These findings converge with prior reports that CTE is largely associated with extensive RHI and is infrequent in a cohort with varying TBI exposures.<\/jats:p>","DOI":"10.1093\/jnen\/nlaf117","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T12:05:52Z","timestamp":1758283552000},"page":"1174-1190","source":"Crossref","is-referenced-by-count":2,"title":["Chronic traumatic encephalopathy neuropathologic change in the Late Effects of Traumatic Brain Injury project: Findings in a community autopsy cohort"],"prefix":"10.1093","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-4566","authenticated-orcid":false,"given":"Enna","family":"Selmanovic","sequence":"first","affiliation":[{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai , New York City, NY,","place":["United States"]},{"name":"Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai , New York City, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley N","family":"Delman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai , New York City, NY,","place":["United States"]},{"name":"Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai , New York City, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Pruyser","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L","family":"Thorn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular, and Cell Based Medicine, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Mount Sinai Hospital , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber L","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington School of Medicine , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington School of Medicine , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular, and Cell Based Medicine, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Mount Sinai Hospital , New York, NY,","place":["United States"]},{"name":"Ronald M. Loeb Center for Alzheimer\u2019s Disease, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Crary","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Department of Pathology, Molecular, and Cell Based Medicine, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]},{"name":"Neuropathology Brain Bank & Research CoRE, Mount Sinai Hospital , New York, NY,","place":["United States"]},{"name":"Ronald M. 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