{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T08:19:02Z","timestamp":1771834742334,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D24FE-605"],"award-info":[{"award-number":["D24FE-605"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumor-associated macrophages (TAMs) are the predominant immune cells in the tumor microenvironment (TME) of human meningiomas. They exhibit different functional phenotypes that contribute either to an anti-inflammatory and anti-tumor response (M1 phenotype), or an immunosuppressive and pro-tumor response (M2 phenotype). In meningiomas of cats, the specific role of TAMs in determining prognosis and post-surgery outcome remains unclear. This study aimed to characterize the macrophage population in feline meningiomas, differentiate M1 from M2 phenotype, and investigate the relationship of the results to prognosis. Fifty-seven surgically removed feline meningiomas were studied. Immunolabeling was performed on formalin-fixed paraffin embedded samples with primary antibodies anti-MAC387 (M1 macrophage), CD163 and CD204 (M2 macrophage), Iba1 (pan-macrophage), and Ki67. The cells in all cases expressed Iba1 and CD163, while MAC387 and CD204-expression varied. Moreover, macrophages were more numerous in high-grade tumors across both M1 and M2 phenotypes. Although none of the markers were predictive of recurrence on Cox models (P\u2009&amp;gt;\u2009.05), based on the significant association between M2 CD163-positive macrophages and high-grade tumors, and their shorter post-surgery recurrence-free times, the results suggest that M2 macrophages might play a role in the behavior and prognosis of feline meningiomas.<\/jats:p>","DOI":"10.1093\/jnen\/nlaf119","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:48:57Z","timestamp":1759232937000},"page":"220-227","source":"Crossref","is-referenced-by-count":0,"title":["Tumor-associated macrophages in feline meningiomas: Exploring their prognostic significance"],"prefix":"10.1093","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-6163","authenticated-orcid":false,"given":"Maria Teresa","family":"Mandara","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia 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