{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:58:56Z","timestamp":1790380736314,"version":"4.1.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Astellas Gene Therapies"},{"name":"Medical College of Wisconsin and Diverge Translational Science Laboratory"},{"name":"Children\u2019s Research Institute\u2019s"},{"DOI":"10.13039\/100006645","name":"Children\u2019s Hospital of Wisconsin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006645","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Paul D. Wellstone Muscular Dystrophy Specialized Research Center"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50NS053672"],"award-info":[{"award-number":["P50NS053672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abnormalities of myofiber size are often of diagnostic significance on skeletal muscle biopsies, mainly when myofibers are excessively small. The establishment of standards for myofiber size in children has been hampered until recently by the lack of tools to assess large numbers of fibers across a sizeable number of samples. This study describes the assessment of myofiber size in 349 histologically normal patient biopsy specimens obtained between 4\u2009weeks and 25\u2009years of life and corresponding primarily to locations in the thigh\/quadriceps\/vastus lateralis region. Biopsy specimens were selected for inclusion based on histologically normal light microscopic findings and minimal technical artifacts. H&amp;E-stained slides were scanned and evaluated for minFeret diameter using a Visiopharm software app (APP #10164). MinFeret diameter fiber size data were then grouped into 18 age cohorts to establish normal ranges for males and females within each age cohort. A pilot study to compare known abnormal cases to these normal ranges was then performed to demonstrate how cases with abnormal fiber size might compare to these standards. This dataset provides a user-friendly and applicable set of standard fiber size ranges to assist in diagnostic and scientific work in children and young adults.<\/jats:p>","DOI":"10.1093\/jnen\/nlaf123","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:37:32Z","timestamp":1762673852000},"page":"1159-1173","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of normal myofiber size distribution in children and young adults"],"prefix":"10.1093","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-3950","authenticated-orcid":false,"given":"Michael W","family":"Lawlor","sequence":"first","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]},{"name":"Diverge Translational Science Laboratory , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Margeta","sequence":"additional","affiliation":[{"name":"University of California San Francisco Department of Pathology, , San Francisco, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karra A","family":"Jones","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Department of Pathology, , Durham, NC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Schoser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University Munich , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-3314","authenticated-orcid":false,"given":"Jennifer A","family":"Cotter","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Los Angeles, Keck School of Medicine of University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Rajaram","sequence":"additional","affiliation":[{"name":"Department of Pathology, UT Southwestern Medical Center. Dallas , TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-7900","authenticated-orcid":false,"given":"Steven A","family":"Moore","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, The University of Iowa , Iowa City, IA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah J","family":"Prom","sequence":"additional","affiliation":[{"name":"Diverge Translational Science Laboratory , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Beatka","sequence":"additional","affiliation":[{"name":"Diverge Translational Science Laboratory , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Ott","sequence":"additional","affiliation":[{"name":"Diverge Translational Science Laboratory , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A","family":"Slick","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]},{"name":"Department of Neurology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Esselman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazima","family":"Shahnoor","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Danielson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Meng","sequence":"additional","affiliation":[{"name":"Diverge Translational Science Laboratory , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatbardha","family":"Varfaj","sequence":"additional","affiliation":[{"name":"Formerly of Astellas Gene Therapies (formerly Audentes Therapeutics) , San Francisco, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyash","family":"Prasad","sequence":"additional","affiliation":[{"name":"Formerly of Astellas Gene Therapies (formerly Audentes Therapeutics) , San Francisco, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Rico","sequence":"additional","affiliation":[{"name":"Formerly of Astellas Gene Therapies (formerly Audentes Therapeutics) , San Francisco, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Formerly of Astellas Gene Therapies (formerly Audentes Therapeutics) , San Francisco, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh N","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Gordish","family":"Dressman","sequence":"additional","affiliation":[{"name":"Children\u2019s National Hospital and the George Washington University , Washington, DC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"2025121810570560800_nlaf123-B1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1212\/WNL.19.6.591","article-title":"The histographic analysis of human muscle biopsies with regard to fiber types. 4. 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