{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:26:35Z","timestamp":1774002395491,"version":"3.50.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cystatin C (CST3) colocalizes with amyloid-\u03b2 (A\u03b2) around vessels in cerebral amyloid angiopathy (CAA). This study aimed to characterize CST3-A\u03b2 interactions in CAA. Brain tissues from 12 Alzheimer disease (AD) and 5 non-AD control subjects, along with AD model mice (J20), were examined. In AD brains, immunohistochemistry revealed A\u03b2 positivity around cortical and leptomeningeal vessels as well as in intra- and extracellular areas. Congo red-positive vessels were also present. Conversely, control brains showed only few A\u03b2-positive cells. CST3 was primarily intracellular in controls, but in AD, it was found both to be intracellular and perivascular, colocalizing with A\u03b2 and Congo red in affected vessels. Vessel quantification showed a positive correlation between CST3-positive and A\u03b2- or Congo red-positive vessels. Moreover, most CST3-positive vessels were Cathepsin B (CatB)-negative. CatB was significantly decreased in AD and inversely correlated with CAA severity. Immunoprecipitation followed by Western blotting, dot blot, and TEM revealed oligomeric aggregates and short fibrillar CST3 bound to A\u03b2 in both AD and J20 mice brains. In J20 mice, CST3 was only neuron-positive at 2\u2009months, and vessel-positive, colocalizing with A\u03b2 from 3\u2009months. These findings suggest that aggregated CST3 binds to A\u03b2 and accumulates around vessels, potentially contributing to CAA pathogenesis.<\/jats:p>","DOI":"10.1093\/jnen\/nlaf138","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:41Z","timestamp":1765976261000},"page":"372-388","source":"Crossref","is-referenced-by-count":1,"title":["Deposition of aggregated cystatin C-amyloid-\u03b2 complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis"],"prefix":"10.1093","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-0225","authenticated-orcid":false,"given":"Jubo","family":"Bhuiya","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu Zaffar","family":"Shibly","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]},{"name":"Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University , Santosh,","place":["Bangladesh"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Md","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shatera","family":"Tabassum","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema Binte","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerin","family":"Fahmida","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro","family":"Tamegai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Aritake","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Shimane University , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine, Shimane University , 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