{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T05:01:53Z","timestamp":1783227713523,"version":"3.54.6"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Japanese Ministry of Health and Welfare Sciences Research","award":["22KA3003"],"award-info":[{"award-number":["22KA3003"]}]},{"name":"JST SPRING","award":["JPMJSP2108"],"award-info":[{"award-number":["JPMJSP2108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aggregation of amyloid-\u03b2 (A\u03b2) and phosphorylated tau (p-tau) in the human brain is associated with Alzheimer disease (AD). Although A\u03b2 aggregation has been reported in various mammals, significant p-tau aggregation has been reported in only a few species. We examined A\u03b2 and p-tau aggregation in the brains of 30 animals belonging to 12 artiodactyl species. Amyloid-\u03b2 aggregates were observed in 2 animals (21 and 22\u2009years old); p-tau aggregates were observed in all animals &amp;gt;9\u2009years of age (n\u2009=\u200912). Regarding tau pathology, mildly affected animals exhibited neuropil threads (NTs), whereas severely affected animals exhibited NTs and neurofibrillary tangles. The most severe p-tau aggregation was observed in the parahippocampal gyrus, basal ganglia, hippocampus, and cerebral cortex. Proteinase K treatment resulted in high proteinase resistance for 4-repeat tau and low resistance for 3-repeat tau. These results suggest that p-tau aggregation occurs prior to A\u03b2 aggregation in artiodactyls, which differs from other mammalian species and human AD. Regarding the distribution, p-tau aggregated in neurites and then in the neuronal cell soma of the parahippocampal gyrus and spread to associated regions of the brain. Moreover, 4-repeat tau was the main component of proteinase-resistant p-tau aggregates in the artiodactyl brains studied.<\/jats:p>","DOI":"10.1093\/jnen\/nlaf139","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:51:09Z","timestamp":1764075069000},"page":"363-371","source":"Crossref","is-referenced-by-count":1,"title":["Phosphorylated tau aggregation in the brains of aged Artiodactyla animals"],"prefix":"10.1093","volume":"85","author":[{"given":"Yutaro","family":"Nakayama","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5273-7221","authenticated-orcid":false,"given":"James K","family":"Chambers","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2026032003520254700_nlaf139-B1","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1212\/WNL.58.11.1629","article-title":"Cerebral amyloid angiopathy and cognitive function","volume":"58","author":"Pfeifer","year":"2002","journal-title":"Neurology."},{"key":"2026032003520254700_nlaf139-B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3174\/ajnr.A0781","article-title":"Neuropathology for the neuroradiologist: plaques and 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