{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:25:53Z","timestamp":1787009153428,"version":"build-2736575974"},"reference-count":119,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer disease (AD) is a widespread neurodegenerative disorder. It is pathologically marked by the deposition of \u03b2-amyloid (A\u03b2) plaques and a high phosphorylation level of tau proteins, resulting in neurofibrillary tangle development, cognitive decline, and neuronal loss. Previous studies showed the correlation between AD and pyroptosis, an inflammasome-mediated programmed cell death. It was reported that A\u03b2 and tau deposits may activate the NOD-like receptor pyrin domain-3 (NLRP3) and inflammasome-caspase-1-gasdermin D (GSDMD) pathway. This leads to cell membrane rupture and discharge of IL-1\u03b2 and IL-18 cytokines that initiate neuroinflammation. However, there is still a lack of research on therapeutic approaches that target the pyroptotic pathway in AD. This review documents recent research on the regulatory function of miRNAs in regulating the NLRP3\/caspase-1\/GSDMD pathways and their potential to lessen pyroptosis-induced neuronal damage. We also address novel platforms for delivering antipyroptotic drugs and miRNA modulators across the blood-brain barrier using nanotechnology, such as engineered nanocarriers and exosome-like nanoparticles. These approaches have a promising therapeutic implication as potential treatment options for AD by combining molecular regulation and nanomedicine.<\/jats:p>","DOI":"10.1093\/jnen\/nlag014","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:41:06Z","timestamp":1771072866000},"page":"697-713","source":"Crossref","is-referenced-by-count":4,"title":["Cross-talk between pyroptosis and miRNAs in Alzheimer disease neuropathology, therapeutic targeting of NLRP inflammasomes, and recent advances in nanoparticle-targeted therapy"],"prefix":"10.1093","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-7300","authenticated-orcid":false,"given":"Hebatallah M","family":"Saad","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Matrouh University , Matruh,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa","family":"Atef","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine, Menoufia University , Shebeen ElKom,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A","family":"Aboushouk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Alexandria University , Alexandria,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5988-6883","authenticated-orcid":false,"given":"Tasnim S","family":"Waheeb","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, Alexandria University , Alexandria,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0900-9896","authenticated-orcid":false,"given":"Abeer E","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Matrouh University , Matruh,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-100X","authenticated-orcid":false,"given":"Salman A A","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University , Buraydah,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026062414274087900_nlag014-B1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat Rev Drug Discov."},{"key":"2026062414274087900_nlag014-B2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1474-4422(07)70291-0","article-title":"Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study","volume":"6","author":"Seshadri","year":"2007","journal-title":"Lancet Neurol."},{"key":"2026062414274087900_nlag014-B3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1474-4422(18)30028-0","article-title":"Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer\u2019s disease: a longitudinal study","volume":"17","author":"Gordon","year":"2018","journal-title":"Lancet Neurol."},{"key":"2026062414274087900_nlag014-B4","doi-asserted-by":"crossref","first-page":"S611","DOI":"10.3233\/JAD-179935","article-title":"Role of amyloid-\u03b2 and tau proteins in Alzheimer\u2019s disease: confuting the amyloid cascade","volume":"64","author":"Gulisano","year":"2018","journal-title":"J Alzheimers Dis."},{"key":"2026062414274087900_nlag014-B5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2016.06.014","article-title":"Insights on the pathophysiology of Alzheimer\u2019s disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system","volume":"68","author":"D\u00e1 Mesquita","year":"2016","journal-title":"Neurosci Biobehav Rev."},{"key":"2026062414274087900_nlag014-B6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.pneurobio.2010.01.002","article-title":"Epigenetic regulation in the pathophysiology of Alzheimer\u2019s disease","volume":"90","author":"Chouliaras","year":"2010","journal-title":"Prog Neurobiol."},{"key":"2026062414274087900_nlag014-B7","doi-asserted-by":"crossref","first-page":"845185","DOI":"10.3389\/fphar.2022.845185","article-title":"The role of NLRP3 inflammasome in Alzheimer\u2019s disease and potential therapeutic targets","volume":"13","author":"Liang","year":"2022","journal-title":"Front Pharmacol."},{"key":"2026062414274087900_nlag014-B8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0966-842X(00)01936-3","article-title":"Pro-inflammatory programmed cell death","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol."},{"key":"2026062414274087900_nlag014-B9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"2026062414274087900_nlag014-B10","doi-asserted-by":"crossref","first-page":"872471","DOI":"10.3389\/fnmol.2022.872471","article-title":"Research progress of pyroptosis in Alzheimer\u2019s disease","volume":"15","author":"Xue","year":"2022","journal-title":"Front Mol Neurosci."},{"key":"2026062414274087900_nlag014-B11","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell Death Differ."},{"key":"2026062414274087900_nlag014-B12","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.12659\/MSM.905064","article-title":"Genome-wide profiling of miRNA and mRNA expression in Alzheimer\u2019s disease","volume":"23","author":"Chang","year":"2017","journal-title":"Med Sci Monit."},{"key":"2026062414274087900_nlag014-B13","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/s41467-021-22196-y","article-title":"miR-135a-5p mediates memory and synaptic impairments via the Rock2\/Adducin1 signaling pathway in a mouse model of Alzheimer\u2019s disease","volume":"12","author":"Zheng","year":"2021","journal-title":"Nat Commun."},{"key":"2026062414274087900_nlag014-B14","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.stem.2021.05.001","article-title":"Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer\u2019s disease","volume":"28","author":"Walgrave","year":"2021","journal-title":"Cell Stem Cell."},{"key":"2026062414274087900_nlag014-B15","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1038\/s41380-019-0610-2","article-title":"MicroRNA-298 reduces levels of human amyloid-\u03b2 precursor protein (APP), \u03b2-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties","volume":"26","author":"Chopra","year":"2021","journal-title":"Mol Psychiatry."},{"key":"2026062414274087900_nlag014-B16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clinbiochem.2018.05.020","article-title":"Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer\u2019s disease","volume":"58","author":"Fransquet","year":"2018","journal-title":"Clin Biochem."},{"key":"2026062414274087900_nlag014-B17","doi-asserted-by":"crossref","first-page":"114387","DOI":"10.1016\/j.bbr.2023.114387","article-title":"miR-181c-5p suppresses neuronal pyroptosis via NLRP1 in Alzheimer\u2019s disease","volume":"447","author":"Wang","year":"2023","journal-title":"Behav Brain Res."},{"key":"2026062414274087900_nlag014-B18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol Rev."},{"key":"2026062414274087900_nlag014-B19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fphys.2020.00381","article-title":"Chemerin\/CMKLR1 axis promotes inflammation and pyroptosis by activating NLRP3 inflammasome in diabetic cardiomyopathy rat","volume":"11","author":"Xie","year":"2020","journal-title":"Front Physiol."},{"key":"2026062414274087900_nlag014-B20","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1242\/jcs.207365","article-title":"Inflammasome activation and assembly at a glance","volume":"130","author":"Malik","year":"2017","journal-title":"J Cell Sci."},{"key":"2026062414274087900_nlag014-B21","doi-asserted-by":"crossref","first-page":"26162","DOI":"10.1038\/srep26162","article-title":"Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells","volume":"6","author":"Naji","year":"2016","journal-title":"Sci Rep."},{"key":"2026062414274087900_nlag014-B22","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology."},{"key":"2026062414274087900_nlag014-B23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell."},{"key":"2026062414274087900_nlag014-B24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell."},{"key":"2026062414274087900_nlag014-B25","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J Mol Sci."},{"key":"2026062414274087900_nlag014-B26","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GSDMD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026062414274087900_nlag014-B27","doi-asserted-by":"crossref","first-page":"111428","DOI":"10.1016\/j.biopha.2021.111428","article-title":"The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases","volume":"138","author":"Feng","year":"2021","journal-title":"Biomed Pharmacother."},{"key":"2026062414274087900_nlag014-B28","doi-asserted-by":"crossref","first-page":"105255","DOI":"10.1016\/j.bioorg.2021.105255","article-title":"N-salicyloyl tryptamine derivatives as potential therapeutic agents for Alzheimer\u2019s disease with neuroprotective effects","volume":"115","author":"Bai","year":"2021","journal-title":"Bioorg Chem."},{"key":"2026062414274087900_nlag014-B29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/biomedicines9050524","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"9","author":"Onyango","year":"2021","journal-title":"Biomedicines."},{"key":"2026062414274087900_nlag014-B30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2147\/NDT.S279147","article-title":"Schisandrin inhibits NLRP1 inflammasome-mediated neuronal pyroptosis in mouse models of Alzheimer\u2019s disease","volume":"17","author":"Li","year":"2021","journal-title":"Neuropsychiatr Dis Treat."},{"key":"2026062414274087900_nlag014-B31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ."},{"key":"2026062414274087900_nlag014-B32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem Sci."},{"key":"2026062414274087900_nlag014-B33","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.immuni.2015.10.009","article-title":"Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity."},{"key":"2026062414274087900_nlag014-B34","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.4049\/jimmunol.1401624","article-title":"Neutrophil IL-1\u03b2 processing induced by pneumolysin is mediated by the NLRP3\/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux","volume":"194","author":"Karmakar","year":"2015","journal-title":"J Immunol."},{"key":"2026062414274087900_nlag014-B35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.immuni.2020.06.007","article-title":"Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage","volume":"53","author":"Liu","year":"2020","journal-title":"Immunity."},{"key":"2026062414274087900_nlag014-B36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature."},{"key":"2026062414274087900_nlag014-B37","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s003350010138","article-title":"Gasdermin (GSDM) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells","volume":"11","author":"Saeki","year":"2000","journal-title":"Mamm Genome."},{"key":"2026062414274087900_nlag014-B38","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov."},{"key":"2026062414274087900_nlag014-B39","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ygeno.2007.01.003","article-title":"Members of a novel gene family, GSDM, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner","volume":"89","author":"Tamura","year":"2007","journal-title":"Genomics."},{"key":"2026062414274087900_nlag014-B40","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.4049\/jimmunol.1100477","article-title":"Coordinated host responses during pyroptosis: caspase-1\u2013dependent lysosome exocytosis and inflammatory cytokine maturation","volume":"187","author":"Bergsbaken","year":"2011","journal-title":"J Immunol"},{"key":"2026062414274087900_nlag014-B41","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"2026062414274087900_nlag014-B42","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation","volume":"10","author":"Rogers","year":"2019","journal-title":"Nat Commun."},{"key":"2026062414274087900_nlag014-B43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature."},{"key":"2026062414274087900_nlag014-B44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-immunol-111319-023800","article-title":"Knocking\u2019em dead: pore-forming proteins in immune defense","volume":"38","author":"Liu","year":"2020","journal-title":"Annu Rev Immunol."},{"key":"2026062414274087900_nlag014-B45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.ai.2017.02.002","article-title":"A mechanistic understanding of pyroptosis: the fiery death triggered by invasive infection","volume":"135","author":"Liu","year":"2017","journal-title":"Adv Immunol"},{"key":"2026062414274087900_nlag014-B46","doi-asserted-by":"crossref","first-page":"1907308","DOI":"10.1002\/smll.201907308","article-title":"Redox-responsive nanobiomaterials-based therapeutics for neurodegenerative diseases","volume":"16","author":"Eleftheriadou","year":"2020","journal-title":"Small"},{"key":"2026062414274087900_nlag014-B47","doi-asserted-by":"crossref","first-page":"1122104","DOI":"10.3389\/fphar.2023.1122104","article-title":"Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine","volume":"14","author":"Liao","year":"2023","journal-title":"Front Pharmacol."},{"key":"2026062414274087900_nlag014-B48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid precursor protein processing and Alzheimer\u2019s disease","volume":"34","author":"O\u2019Brien","year":"2011","journal-title":"Annu Rev Neurosci."},{"key":"2026062414274087900_nlag014-B49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00401-022-02528-y","article-title":"Pyroptosis in Alzheimer\u2019s disease: cell type-specific activation in microglia, astrocytes and neurons","volume":"145","author":"Moonen","year":"2023","journal-title":"Acta Neuropathol."},{"key":"2026062414274087900_nlag014-B50","doi-asserted-by":"crossref","first-page":"e1382","DOI":"10.1038\/cddis.2014.348","article-title":"Amyloid-\u03b2 induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer\u2019s disease","volume":"5","author":"Tan","year":"2014","journal-title":"Cell Death Dis."},{"key":"2026062414274087900_nlag014-B51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12017-013-8274-6","article-title":"Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10","volume":"16","author":"Murphy","year":"2014","journal-title":"Neuromolecular Med."},{"key":"2026062414274087900_nlag014-B52","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.bbadis.2014.08.001","article-title":"Amyloid-\u03b2(1-42) protofibrils stimulate a quantum of secreted IL-1\u03b2 despite significant intracellular IL-1\u03b2 accumulation in microglia","volume":"1842","author":"Terrill-Usery","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2026062414274087900_nlag014-B53","doi-asserted-by":"crossref","first-page":"135279","DOI":"10.1016\/j.neulet.2020.135279","article-title":"Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia","volume":"736","author":"Liu","year":"2020","journal-title":"Neurosci Lett."},{"key":"2026062414274087900_nlag014-B54","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"Halle","year":"2008","journal-title":"Nat Immunol."},{"key":"2026062414274087900_nlag014-B55","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat Rev Neurosci."},{"key":"2026062414274087900_nlag014-B56","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/jnc.14945","article-title":"Soluble A\u03b2 oligomers and protofibrils induce NLRP3 inflammasome activation in microglia","volume":"155","author":"Lu\u010di\u016bnait\u0117","year":"2020","journal-title":"J Neurochem."},{"key":"2026062414274087900_nlag014-B57","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1111\/jcmm.15439","article-title":"New mechanism of nerve injury in Alzheimer\u2019s disease: \u03b2-amyloid-induced neuronal pyroptosis","volume":"24","author":"Han","year":"2020","journal-title":"J Cell Mol Med."},{"key":"2026062414274087900_nlag014-B58","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","article-title":"Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer\u2019s disease model","volume":"187","author":"Kitazawa","year":"2011","journal-title":"J Immunol."},{"key":"2026062414274087900_nlag014-B59","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature."},{"key":"2026062414274087900_nlag014-B60","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","article-title":"Aggregated tau activates NLRP3\u2013ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded tau pathology in vivo","volume":"137","author":"Stancu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"2026062414274087900_nlag014-B61","doi-asserted-by":"crossref","first-page":"721474","DOI":"10.3389\/fnagi.2021.721474","article-title":"NLRP3 inflammasome-dependent increases in high mobility group box 1 involved in the cognitive dysfunction caused by tau-overexpression","volume":"13","author":"Zhao","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"2026062414274087900_nlag014-B62","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-021-02329-2","article-title":"Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer\u2019s disease","volume":"18","author":"Rui","year":"2021","journal-title":"J Neuroinflammation."},{"key":"2026062414274087900_nlag014-B63","doi-asserted-by":"crossref","first-page":"e02063","DOI":"10.1002\/brb3.2063","article-title":"Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer\u2019s disease","volume":"11","author":"Shen","year":"2021","journal-title":"Brain Behav."},{"key":"2026062414274087900_nlag014-B64","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41590-021-01017-w","article-title":"Mitochondria control pyroptosis","volume":"22","author":"Bernard","year":"2021","journal-title":"Nat Immunol."},{"key":"2026062414274087900_nlag014-B65","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1111\/jcmm.16787","article-title":"ADMSC exo-microRNA-22 improve neurological function and neuroinflammation in mice with Alzheimer\u2019s disease","volume":"25","author":"Zhai","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2026062414274087900_nlag014-B66","first-page":"540","article-title":"miR-212-3p attenuates neuroinflammation of rats with Alzheimer\u2019s disease via regulating the SP1\/BACE1\/NLRP3\/caspase-1 signaling pathway","volume":"22","author":"Nong","year":"2022","journal-title":"Bosn J Basic Med Sci."},{"key":"2026062414274087900_nlag014-B67","doi-asserted-by":"crossref","first-page":"653881","DOI":"10.3389\/fncel.2021.653881","article-title":"NF-\u03baB-induced upregulation of miR-146a-5p promoted hippocampal neuronal oxidative stress and pyroptosis via TIGAR in a model of Alzheimer\u2019s disease","volume":"15","author":"Lei","year":"2021","journal-title":"Front Cell Neurosci."},{"key":"2026062414274087900_nlag014-B68","doi-asserted-by":"crossref","first-page":"570711","DOI":"10.3389\/fneur.2020.570711","article-title":"The role of microglia and the Nlrp3 inflammasome in Alzheimer\u2019s disease","volume":"11","author":"Hanslik","year":"2020","journal-title":"Front Neurol."},{"key":"2026062414274087900_nlag014-B69","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2147\/JIR.S304461","article-title":"MicroRNA-138-5p regulates hippocampal neuroinflammation and cognitive impairment by NLRP3\/caspase-1 signaling pathway in rats","volume":"14","author":"Feng","year":"2021","journal-title":"J Inflamm Res."},{"key":"2026062414274087900_nlag014-B70","doi-asserted-by":"crossref","first-page":"147228","DOI":"10.1016\/j.brainres.2020.147228","article-title":"MicroNAR-194-5p hinders the activation of NLRP3 inflammasomes and alleviates neuroinflammation during intracerebral hemorrhage by blocking the interaction between TRAF6 and NLRP3","volume":"1752","author":"Wan","year":"2021","journal-title":"Brain Res."},{"key":"2026062414274087900_nlag014-B71","doi-asserted-by":"crossref","first-page":"809433","DOI":"10.3389\/fnagi.2021.809433","article-title":"Salidroside ameliorates Alzheimer\u2019s disease by targeting NLRP3 inflammasome-mediated pyroptosis","volume":"13","author":"Cai","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"2026062414274087900_nlag014-B72","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1021\/acs.molpharmaceut.9b00246","article-title":"Exosome-like nanoparticles from ginger rhizomes inhibited NLRP3 inflammasome activation","volume":"16","author":"Chen","year":"2019","journal-title":"Mol Pharm."},{"key":"2026062414274087900_nlag014-B73","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1166\/jbn.2024.3786","article-title":"Regulation of neuronal pyroptosis through NLRP3 by delivering miR-22 using lipid nanoparticles in mice with cerebral ischemia-reperfusion injury","volume":"20","author":"Wang","year":"2024","journal-title":"J Biomed Nanotechnol."},{"key":"2026062414274087900_nlag014-B74","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2147\/NDT.S279304","article-title":"Bushen Huoxue Acupuncture inhibits NLRP1 inflammasome-mediated neuronal pyroptosis in SAMP8 mouse model of Alzheimer\u2019s disease","volume":"17","author":"Zhang","year":"2021","journal-title":"Neuropsychiatr Dis Treat."},{"key":"2026062414274087900_nlag014-B75","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12035-024-04255-9","article-title":"Pyroptosis signature gene CHMP4B regulates microglia pyroptosis by inhibiting GSDMD in Alzheimer\u2019s disease","volume":"62","author":"Ding","year":"2025","journal-title":"Mol Neurobiol"},{"key":"2026062414274087900_nlag014-B76","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s12035-017-0467-9","article-title":"NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer\u2019s disease","volume":"55","author":"Yin","year":"2018","journal-title":"Mol Neurobiol."},{"key":"2026062414274087900_nlag014-B77","doi-asserted-by":"crossref","first-page":"10534","DOI":"10.1111\/jcmm.16984","article-title":"Mafenide derivatives inhibit neuroinflammation in Alzheimer\u2019s disease by regulating pyroptosis","volume":"25","author":"Han","year":"2021","journal-title":"J Cell Mol Med."},{"key":"2026062414274087900_nlag014-B78","doi-asserted-by":"crossref","first-page":"106263","DOI":"10.1016\/j.intimp.2020.106263","article-title":"CSB6B prevents \u03b2-amyloid-associated neuroinflammation and cognitive impairments via inhibiting NF-\u03baB and NLRP3 in microglia cells","volume":"81","author":"Yan","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"2026062414274087900_nlag014-B79","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1096\/fj.201901537R","article-title":"Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly","volume":"34","author":"Shi","year":"2020","journal-title":"FASEB J."},{"key":"2026062414274087900_nlag014-B80","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"He","year":"2018","journal-title":"Nat Commun."},{"key":"2026062414274087900_nlag014-B81","doi-asserted-by":"crossref","first-page":"e104745","DOI":"10.1371\/journal.pone.0104745","article-title":"Oridonin attenuates A\u03b21-42-induced neuroinflammation and inhibits NF-\u03baB pathway","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One."},{"key":"2026062414274087900_nlag014-B82","doi-asserted-by":"crossref","first-page":"557170","DOI":"10.3389\/fnins.2020.557170","article-title":"Neuroprotective effect of oridonin on traumatic brain injury via inhibiting NLRP3 inflammasome in experimental mice","volume":"14","author":"Yan","year":"2020","journal-title":"Front Neurosci."},{"key":"2026062414274087900_nlag014-B83","doi-asserted-by":"crossref","first-page":"e015513","DOI":"10.1161\/JAHA.119.015513","article-title":"Novel role for tranilast in regulating NLRP 3 ubiquitination, vascular inflammation, and atherosclerosis","volume":"9","author":"Chen","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2026062414274087900_nlag014-B84","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12017-021-08675-x","article-title":"Tranilast, a transient receptor potential vanilloid 2 channel (TRPV2) inhibitor attenuates amyloid \u03b2-induced cognitive impairment: possible mechanisms","volume":"24","author":"Thapak","year":"2022","journal-title":"Neuromolecular Med."},{"key":"2026062414274087900_nlag014-B85","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"Lamkanfi","year":"2009","journal-title":"J Cell Biol."},{"key":"2026062414274087900_nlag014-B86","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1046\/j.0022-202x.2001.01451.x","article-title":"Inhibition of ATP-binding cassette transporter downregulates interleukin-1\u03b2-mediated autocrine activation of human dermal fibroblasts","volume":"117","author":"Lottaz","year":"2001","journal-title":"J Invest Dermatol."},{"key":"2026062414274087900_nlag014-B87","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1021\/acs.jmedchem.8b00733","article-title":"Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization","volume":"61","author":"Fulp","year":"2018","journal-title":"J Med Chem."},{"key":"2026062414274087900_nlag014-B88","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2018.02.016","article-title":"NLRP3-dependent synaptic plasticity deficit in an Alzheimer\u2019s disease amyloidosis model in vivo","volume":"114","author":"Qi","year":"2018","journal-title":"Neurobiol Dis."},{"key":"2026062414274087900_nlag014-B89","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroscience.2018.02.046","article-title":"Chronic amyloid \u03b2 oligomer infusion evokes sustained inflammation and microglial changes in the rat hippocampus via NLRP3","volume":"405","author":"Fekete","year":"2019","journal-title":"Neuroscience."},{"key":"2026062414274087900_nlag014-B90","first-page":"21","article-title":"Advances in the study of anti-tumor effects of Rhodiola rosea","volume":"4","author":"Jin","year":"2023","journal-title":"Trans Cancer"},{"key":"2026062414274087900_nlag014-B91","doi-asserted-by":"crossref","first-page":"1400981","DOI":"10.3389\/fphar.2024.1400981","article-title":"Effects of salidroside on atherosclerosis: potential contribution of gut microbiota","volume":"15","author":"Fei","year":"2024","journal-title":"Front Pharmacol."},{"key":"2026062414274087900_nlag014-B92","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med."},{"key":"2026062414274087900_nlag014-B93","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neulet.2018.10.048","article-title":"Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer\u2019s disease","volume":"690","author":"Ota","year":"2019","journal-title":"Neurosci Lett."},{"key":"2026062414274087900_nlag014-B94","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.neurobiolaging.2012.11.023","article-title":"A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer\u2019s disease","volume":"34","author":"Kashiwaya","year":"2013","journal-title":"Neurobiol Aging."},{"key":"2026062414274087900_nlag014-B95","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s13311-019-00792-7","article-title":"Picrorhiza kurroa prevents memory deficits by inhibiting NLRP3 inflammasome activation and BACE1 expression in 5xFAD mice","volume":"17","author":"Kim","year":"2020","journal-title":"Neurotherapeutics."},{"key":"2026062414274087900_nlag014-B96","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/cns.12983","article-title":"Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP 3 inflammasome activation in APP\/PS 1 transgenic mice","volume":"24","author":"Feng","year":"2018","journal-title":"CNS Neurosci Ther."},{"key":"2026062414274087900_nlag014-B97","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1089\/ars.2017.7440","article-title":"Dl-3-n-butylphthalide inhibits NLRP3 inflammasome and mitigates Alzheimer\u2019s-like pathology via Nrf2-TXNIP-TrX axis","volume":"30","author":"Wang","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"2026062414274087900_nlag014-B98","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12640-020-00284-z","article-title":"Liquiritigenin decreases A\u03b2 levels and ameliorates cognitive decline by regulating microglia M1\/M2 transformation in AD mice","volume":"39","author":"Du","year":"2021","journal-title":"Neurotox Res."},{"key":"2026062414274087900_nlag014-B99","first-page":"15620","article-title":"Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer\u2019s disease cell and mouse models for neuroprotection and cognitive improvement","volume":"13","author":"Chiu","year":"2021","journal-title":"Aging (Albany N Y)"},{"key":"2026062414274087900_nlag014-B100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2018.12.030","article-title":"MiR-34c ameliorates neuropathic pain by targeting NLRP3 in a mouse model of chronic constriction injury","volume":"399","author":"Xu","year":"2019","journal-title":"Neuroscience."},{"key":"2026062414274087900_nlag014-B101","doi-asserted-by":"crossref","first-page":"e21942","DOI":"10.1016\/j.heliyon.2023.e21942","article-title":"The study of therapeutic efficacy and mechanisms of Schisandra chinensis and Evodia rutaecarpa combined treatment in a rat model of Alzheimer\u2019s disease","volume":"9","author":"Cao","year":"2023","journal-title":"Heliyon."},{"key":"2026062414274087900_nlag014-B102","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3897\/pharmacia.70.e108995","article-title":"Pyroptosis and necroptosis inhibitor necrosulfonamide ameliorates lipopolysaccharide-induced inflammatory hyperalgesia in mice","volume":"70","author":"Ozgen","year":"2023","journal-title":"Pharmacia"},{"key":"2026062414274087900_nlag014-B103","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/s41467-020-18405-9","article-title":"Pre-symptomatic caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging","volume":"11","author":"Flores","year":"2020","journal-title":"Nat Commun."},{"key":"2026062414274087900_nlag014-B104","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s10020-021-00273-8","article-title":"Caspase-1\/IL-1\u03b2 represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer\u2019s disease","volume":"27","author":"Gu","year":"2021","journal-title":"Mol Med."},{"key":"2026062414274087900_nlag014-B105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A mutation in APP protects against Alzheimer\u2019s disease and age-related cognitive decline","volume":"488","author":"Jonsson","year":"2012","journal-title":"Nature."},{"key":"2026062414274087900_nlag014-B106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"Van Dyck","year":"2023","journal-title":"N Engl J Med."},{"key":"2026062414274087900_nlag014-B107","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/d41586-023-00030-3","article-title":"FDA approves Alzheimer\u2019s drug amid safety concerns","volume":"613","author":"Reardon","year":"2023","journal-title":"Nature."},{"key":"2026062414274087900_nlag014-B108","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early Alzheimer\u2019s disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N Engl J Med."},{"key":"2026062414274087900_nlag014-B109","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/d41573-024-00180-7","article-title":"Anti-tau antibody stumbles in phase II Alzheimer trial","volume":"23","author":"Mullard","year":"2024","journal-title":"Nat Rev Drug Discov."},{"key":"2026062414274087900_nlag014-B110","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41591-023-02326-3","article-title":"Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer\u2019s disease: a phase 1b, randomized, placebo-controlled trial","volume":"29","author":"Mummery","year":"2023","journal-title":"Nat Med."},{"key":"2026062414274087900_nlag014-B111","doi-asserted-by":"crossref","first-page":"101996","DOI":"10.1016\/j.arr.2023.101996","article-title":"Passive Alzheimer\u2019s immunotherapy: a promising or uncertain option?","volume":"90","author":"H\u00f8ilund-Carlsen","year":"2023","journal-title":"Ageing Res Rev."},{"key":"2026062414274087900_nlag014-B112","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.trsl.2022.06.016","article-title":"Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)","volume":"251","author":"de Rivero Vaccari","year":"2023","journal-title":"Transl Res."},{"key":"2026062414274087900_nlag014-B113","doi-asserted-by":"crossref","first-page":"1196413","DOI":"10.3389\/fphar.2023.1196413","article-title":"Alzheimer\u2019s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?","volume":"14","author":"Melchiorri","year":"2023","journal-title":"Front Pharmacol."},{"key":"2026062414274087900_nlag014-B114","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00221-020-05916-6","article-title":"Protection of MCC950 against Alzheimer\u2019s disease via inhibiting neuronal pyroptosis in SAMP8 mice","volume":"238","author":"Li","year":"2020","journal-title":"Exp Brain Res."},{"key":"2026062414274087900_nlag014-B115","doi-asserted-by":"crossref","first-page":"111826","DOI":"10.1016\/j.mad.2023.111826","article-title":"Involvement of miRNA on epigenetics landscape of Parkinson\u2019s disease: from pathogenesis to therapeutics","volume":"213","author":"Uppala","year":"2023","journal-title":"Mech Ageing Dev."},{"key":"2026062414274087900_nlag014-B116","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3390\/ph16111590","article-title":"Glibenclamide-loaded nanoparticles reduce NLRP3 inflammasome activation and modulate miR-223-3p\/miR-7-1-5p expression in THP-1 cells","volume":"16","author":"Mancuso","year":"2023","journal-title":"Pharmaceuticals"},{"key":"2026062414274087900_nlag014-B117","doi-asserted-by":"crossref","first-page":"1405423","DOI":"10.3389\/fphar.2024.1405423","article-title":"Functionalized nanoparticles to deliver nucleic acids to the brain for the treatment of Alzheimer\u2019s disease","volume":"15","author":"Muolokwu","year":"2024","journal-title":"Front Pharmacol"},{"key":"2026062414274087900_nlag014-B118","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s10142-023-01268-w","article-title":"NLRP3\/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia","volume":"23","author":"Wu","year":"2023","journal-title":"Funct Integr Genomics"},{"key":"2026062414274087900_nlag014-B119","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/molecules30010043","article-title":"A review on current aspects of curcumin-based effects in relation to neurodegenerative, neuroinflammatory and cerebrovascular diseases","volume":"30","author":"Moldoveanu","year":"2024","journal-title":"Molecules"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/85\/7\/697\/67340513\/nlag014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/85\/7\/697\/67340513\/nlag014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:27:59Z","timestamp":1782325679000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/85\/7\/697\/8519431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":119,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,3,13]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlag014","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,3,13]]}}}