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Emerging molecular diagnostics such as circular RNA (circRNA) profiling show potential for enhancing diagnostic accuracy but are limited by the processing workflows associated with traditional fresh-frozen protocols that may lead to biomarker degradation. The NICO Automated Preservation System (APS) is a surgical tool that aspirates and resects intact tumor cores, quickly storing the removed tissue in a refrigerated environment of Ringer\u2019s Lactate fluid. To overcome the challenge of obtaining and preserving tissue for molecular diagnostics, we sought to test the extent to which the NICO APS enhances tissue preservation versus traditional protocols in 20 meningioma resections; we focused on circRNA profiles as potential clinical biomarkers. The NICO APS enhanced RNA integrity (P\u2009=\u2009.0023), yielding high-quality data (&amp;gt;Q30 median\u2009=\u200995%), which reduced the variation of circRNA detection. Weighted Gene Co-expression Network Analysis identified a total of 4 modules highlighting NICO and traditional protocols and meningioma grades. Modules belonging to WHO grade 2 meningiomas may be associated with cellular metabolism and epitranscriptomic regulation. Our results show that circRNA detection is highly improved using NICO APS.<\/jats:p>","DOI":"10.1093\/jnen\/nlag030","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:43:14Z","timestamp":1774356194000},"page":"1278-1290","source":"Crossref","is-referenced-by-count":0,"title":["NICO Myriad Automated Preservation System improves meningioma sample quality for molecular pathology assays"],"prefix":"10.1093","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-3598","authenticated-orcid":false,"given":"Glaucia Maria","family":"de Mendon\u00e7a Fernandes","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Florida International University Herbert Wertheim College of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-5049","authenticated-orcid":false,"given":"Kyle 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International University Herbert Wertheim College of Medicine , Miami, FL,","place":["United States"]},{"name":"Department of Neuropathology and Clinical Informatics, Baptist Health South Florida , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-2339","authenticated-orcid":false,"given":"Daniel M","family":"Prevedello","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The Ohio State University Wexner Medical Center and James Cancer Center , Columbus, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026101909022033000_nlag030-B1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a 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