{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:36:52Z","timestamp":1786113412625,"version":"build-2736575974"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017548","name":"Schoen Adams Research Institute at Spaulding Rehabilitation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017548","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wounded Warrior Project to conduct research relating to CTE and traumatic encephalopathy syndrome, but not for this study"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Astrocytes play essential roles in various functions including ionic homeostasis, energy metabolism, neurotransmission, and regulation of the blood-brain barrier. Researchers have reported that hyperphosphorylated tau in astrocytes can be identified in postmortem, particularly in individuals over the age of 60 years. Astrocytic p-tau has also been reported in association with chronic traumatic encephalopathy neuropathologic change (CTE-NC). This study investigates possible association between subpial aging-related tau astrogliopathy (ARTAG) and a history of playing high school American-style football. Postmortem brain tissue samples were obtained from 176 men (median age at death\u2009=\u200965\u2009years; range\u2009=\u200950-96) from the Lieber Institute for Brain Development. There were 128 with no known history of participating in contact or collision sports and 48 (27.3%) who participated in football. Subpial ARTAG was identified in 23 cases (13.1%). Those who participated in football had a higher percentage with subpial ARTAG than those who did not participate in football (20.8% vs 10.2%), although this difference was not statistically significant (P\u00a0=.061). The 2 groups did not differ in the percentages who had subpial ARTAG in a sulcal depth (10.4% of former football players and 7.8% of controls). More research is needed to understand possible associations between subpial ARTAG, aging, and CTE-NC.<\/jats:p>","DOI":"10.1093\/jnen\/nlag032","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:43:15Z","timestamp":1778845395000},"page":"868-880","source":"Crossref","is-referenced-by-count":0,"title":["Cortical subpial aging-related tau astrogliopathy in older adult men who participated in youth amateur American-style football"],"prefix":"10.1093","volume":"85","author":[{"given":"Grant L","family":"Iverson","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital , Charlestown, MA,","place":["United States"]},{"name":"Department of Physical Medicine and Rehabilitation, Schoen Adams Research Institute at Spaulding Rehabilitation , Charlestown, MA,","place":["United States"]},{"name":"Mass General Brigham for Children Sports Concussion Program , Boston, MA,","place":["United States"]},{"name":"Home Base, A Red Sox Foundation and Massachusetts General Hospital Program , Charlestown, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Deep-Soboslay","sequence":"additional","affiliation":[{"name":"Lieber Institute for Brain Development, Johns Hopkins Medical Campus , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Hyde","sequence":"additional","affiliation":[{"name":"Lieber Institute for Brain Development, Johns Hopkins Medical Campus , Baltimore, MD,","place":["United States"]},{"name":"Department of Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine , Baltimore, MD,","place":["United States"]},{"name":"Department of Neurology, Johns Hopkins School of Medicine , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E","family":"Kleinman","sequence":"additional","affiliation":[{"name":"Lieber Institute for Brain Development, Johns Hopkins Medical Campus , Baltimore, MD,","place":["United States"]},{"name":"Department of Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick, NSW,","place":["Australia"]},{"name":"School of Biomedical Sciences, University of New South Wales , Kensington, 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