{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:43:05Z","timestamp":1786120985674,"version":"build-2736575974"},"reference-count":54,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alzheimer\u2019s Drug Discovery Foundation","award":["GC-202008-2020689"],"award-info":[{"award-number":["GC-202008-2020689"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG080502"],"award-info":[{"award-number":["R21AG080502"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG088509"],"award-info":[{"award-number":["R21AG088509"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG097508"],"award-info":[{"award-number":["R01AG097508"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>TDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE-NC). These proteinopathies exhibit subtype-specific aggregate architectures that may constrain epitope accessibility in situ. We compared a phosphorylation-independent monoclonal antibody targeting a C-terminal epitope (MAb No.\u202f9) with the phospho-specific pSer409\/410 antibody to determine whether its signal relates to regional neurodegeneration in a multicenter autopsy cohort spanning FTLD-TDP types A-C, ALS-TDP, and Alzheimer disease neuropathologic change (ADNC) with or without LATE-NC. Immunolabeling with MAb No.\u202f9 detected pathological TDP-43 across all diagnostic groups with enhanced labeling of dystrophic neurites and thread\/dot-like pathology in FTLD-TDP types A\/B and in ALS-TDP. MAb No. 9 performance was equivalent to p409\/410 in FTLD-TDP type C. In ADNC with stage 3 LATE-NC, MAb No.\u202f9 revealed a greater limbic burden and labeled both \u03b1 type and \u03b2 type inclusions. Dual label immunofluorescence demonstrated strong spatial overlap with p409\/410 but additionally highlighted fine punctate pathology. MAb No.\u202f9 burden in FTLD-TDP type A correlated strongly with cortical neurodegeneration but showed weaker and variable associations, particularly in severely atrophic cortex. These findings indicate that filament architecture governs C-terminal epitope accessibility and that MAb No.\u202f9 may be a complementary tool for subtype refinement, clinicopathologic correlation and translational biomarker development in TDP-43 proteinopathies.<\/jats:p>","DOI":"10.1093\/jnen\/nlag085","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:56:19Z","timestamp":1784807779000},"source":"Crossref","is-referenced-by-count":0,"title":["A phosphorylation\u2011independent monoclonal antibody improves detection of TDP\u201143 pathology across frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and limbic predominant age related TDP\u201143 encephalopathy neuropathological change"],"prefix":"10.1093","author":[{"given":"Xiaojing","family":"Zheng","sequence":"first","affiliation":[{"name":"Laboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University , Xi\u2019an, Shaanxi,","place":["P.R. 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