{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:38:57Z","timestamp":1790462337879,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01 AG016976"],"award-info":[{"award-number":["U01 AG016976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"DOI":"10.1093\/jnen\/nlw026","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T23:13:28Z","timestamp":1461366808000},"page":"516-526","source":"Crossref","is-referenced-by-count":97,"title":["Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum"],"prefix":"10.1093","volume":"75","author":[{"given":"Alberto","family":"Serrano-Pozo","sequence":"first","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qian","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alona","family":"Muzikansky","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E","family":"Monsell","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Montine","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P","family":"Frosch","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A","family":"Betensky","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T","family":"Hyman","sequence":"additional","affiliation":[{"name":"From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washingt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B3","first-page":"S1","article-title":"The National Institute on Aging, and Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of alzheimer\u2019s disease","volume":"18","author":"Consensus recommendations for the postmortem diagnosis of Alzheimer\u2019s disease","year":"1997","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B4","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of a beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B8","doi-asserted-by":"crossref","first-page":"e1000180","DOI":"10.1371\/journal.pmed.1000180","article-title":"Epidemiological pathology of dementia: Attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study","volume":"6","author":"Matthews","year":"2009","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(00)03589-3","article-title":"Medical Research Council Cognitive Function and Aging Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)","volume":"357","author":"Neuropathology Group","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B10","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/NEN.0000000000000016","article-title":"Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center","volume":"72","author":"Serrano-Pozo","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/WAD.0b013e318142774e","article-title":"The National Alzheimer\u2019s Coordinating Center (NACC) database: The Uniform Data Set","volume":"21","author":"Beekly","year":"2007","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.wad.0000213865.09806.92","article-title":"The Uniform Data Set (UDS): Clinical and cognitive variables and descriptive data from Alzheimer Disease Centers","volume":"20","author":"Morris","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/WAD.0b013e318191c7dd","article-title":"The Alzheimer\u2019s Disease Centers\u2019 Uniform Data Set (UDS): The neuropsychologic test battery","volume":"23","author":"Weintraub","year":"2009","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ana.22055","article-title":"Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort","volume":"68","author":"Dolan","year":"2010","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B15","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/ana.21208","article-title":"Pathological correlates of dementia in a longitudinal, population-based sample of aging","volume":"62","author":"Sonnen","year":"2007","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B17","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): Current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B19","doi-asserted-by":"crossref","DOI":"10.1002\/0471249688","volume-title":"Categorical Data Analysis [Internet]","author":"Agresti","year":"2002"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v032.i10","article-title":"The VGAM package for categorical data analysis","volume":"32","author":"Yee","year":"2010","journal-title":"J Stat Softw"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B21","year":"2011"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B22","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/brain\/awv050","article-title":"Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer\u2019s disease spectrum","volume":"138","author":"Murray","year":"2015","journal-title":"Brain"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B23","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00401-014-1308-9","article-title":"A comparison of A\u03b2 amyloid pathology staging systems and correlation with clinical diagnosis","volume":"128","author":"Boluda","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B24","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jalz.2015.05.018","article-title":"[(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer\u2019s disease: Specific detection of advanced phases of amyloid-\u03b2 pathology","volume":"11","author":"Thal","year":"2015","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B25","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1212\/WNL.42.9.1681","article-title":"Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer\u2019s disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B26","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","article-title":"Neuropathology of cognitively normal elderly","volume":"62","author":"Knopman","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B27","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","article-title":"Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease","volume":"30","author":"Price","year":"2009","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1212\/WNL.55.3.370","article-title":"\u201cPreclinical\u201d AD revisited: Neuropathology of cognitively normal older adults","volume":"55","author":"Schmitt","year":"2000","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B29","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/BF00305876","article-title":"Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer\u2019s disease: Relationship with the intellectual status of 26 cases","volume":"81","author":"Dela\u00e8re","year":"1991","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1212\/WNL.43.1_Part_1.192","article-title":"Quantitative synaptic alterations in the human neocortex during normal aging","volume":"43","author":"Masliah","year":"1993","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B31","first-page":"1293","article-title":"Diffuse plaques do not accentuate synapse loss in Alzheimer\u2019s disease","volume":"137","author":"Masliah","year":"1990","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B32","first-page":"309","article-title":"Diffuse senile plaques occur commonly in the cerebellum in Alzheimer\u2019s disease","volume":"135","author":"Joachim","year":"1989","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00005072-199001000-00004","article-title":"Modified Bielschowsky and immunocytochemical studies on cerebellar plaques in Alzheimer\u2019s disease","volume":"49","author":"Suenaga","year":"1990","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B34","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00005072-199807000-00004","article-title":"Diffuse, lake-like amyloid-beta deposits in the parvopyramidal layer of the presubiculum in Alzheimer disease","volume":"57","author":"Wisniewski","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00334497","article-title":"Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia","volume":"81","author":"Grundke-Iqbal","year":"1990","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(89)90115-X","article-title":"Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease","volume":"24","author":"Itagaki","year":"1989","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B37","first-page":"1101","article-title":"Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors","volume":"136","author":"Mattiace","year":"1990","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00294609","article-title":"Microglia in cerebellar plaques in Alzheimer\u2019s disease","volume":"80","author":"Mattiace","year":"1990","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B39","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF00305864","article-title":"Increased senile plaques without microglia in Alzheimer\u2019s disease","volume":"81","author":"Ohgami","year":"1991","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B40","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s004010050713","article-title":"Microglial activation in early stages of amyloid beta protein deposition","volume":"94","author":"Sasaki","year":"1997","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t2018112211323950100_nlw026-B41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00005072-199603000-00002","article-title":"Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer\u2019s disease","volume":"55","author":"Mrak","year":"1996","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/75\/6\/516\/26697006\/nlw026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T18:55:45Z","timestamp":1718477745000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/75\/6\/516\/2579799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,20]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,4,20]]},"published-print":{"date-parts":[[2016,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlw026","relation":{},"ISSN":["1554-6578","0022-3069"],"issn-type":[{"value":"1554-6578","type":"electronic"},{"value":"0022-3069","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,6]]},"published":{"date-parts":[[2016,4,20]]}}}