{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:00:09Z","timestamp":1780106409947,"version":"3.54.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"DOI":"10.1093\/jnen\/nlw103","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T01:50:13Z","timestamp":1484013013000},"page":"nlw103","source":"Crossref","is-referenced-by-count":22,"title":["The Search for a Peripheral Biopsy Indicator of \u03b1-Synuclein Pathology for Parkinson Disease"],"prefix":"10.1093","author":[{"given":"John M.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Derkinderen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Kordower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner","family":"Zago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Hutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geidy E.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Beach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"2017010917501004000_nlw103v1.1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000113469","article-title":"Neuropathology of autonomic nervous system in Parkinson\u2019s disease","volume":"38 Suppl 2","author":"Wakabayashi","year":"1997","journal-title":"Eur Neurol"},{"key":"2017010917501004000_nlw103v1.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687767"},{"key":"2017010917501004000_nlw103v1.3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1679\/aohc.52.Suppl_191","article-title":"Lewy bodies in the enteric nervous system in Parkinson\u2019s disease","volume":"52 Suppl","author":"Wakabayashi","year":"1989","journal-title":"Arch Histol Cytol"},{"key":"2017010917501004000_nlw103v1.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294234"},{"key":"2017010917501004000_nlw103v1.5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/0016-5085(84)90079-9","article-title":"Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson\u2019s disease","volume":"87","author":"Qualman","year":"1984","journal-title":"Gastroenterology"},{"key":"2017010917501004000_nlw103v1.6","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1212\/WNL.37.7.1253","article-title":"Parkinson\u2019s disease and megacolon: Concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells","volume":"37","author":"Kupsky","year":"1987","journal-title":"Neurology"},{"key":"2017010917501004000_nlw103v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.11.012"},{"key":"2017010917501004000_nlw103v1.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0808-2"},{"key":"2017010917501004000_nlw103v1.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00874.x"},{"key":"2017010917501004000_nlw103v1.10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fpsyt.2010.00128","article-title":"Biopsable neural tissues: Toward new biomarkers for Parkinson\u2019s disease?","volume":"1","author":"Lebouvier","year":"2010","journal-title":"Front Psychiatry"},{"key":"2017010917501004000_nlw103v1.11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24648"},{"key":"2017010917501004000_nlw103v1.12","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22172"},{"key":"2017010917501004000_nlw103v1.13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2011.08.014","article-title":"A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson\u2019s disease","volume":"45","author":"Pouclet","year":"2012","journal-title":"Neurobiol Dis"},{"key":"2017010917501004000_nlw103v1.14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2015.07.005","article-title":"synuclein immunoreactivity patterns in the enteric nervous system","volume":"602","author":"Aldecoa","year":"2015","journal-title":"Neurosci Lett"},{"key":"2017010917501004000_nlw103v1.15","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25020"},{"key":"2017010917501004000_nlw103v1.16","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23838"},{"key":"2017010917501004000_nlw103v1.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012728"},{"key":"2017010917501004000_nlw103v1.18","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1111\/j.1365-2982.2009.01368.x","article-title":"Routine colonic biopsies as a new tool to study the enteric nervous system in living patients","volume":"22","author":"Lebouvier","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"2017010917501004000_nlw103v1.19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.162503"},{"key":"2017010917501004000_nlw103v1.20","first-page":"305","article-title":"A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson\u2019s disease","volume":"45","author":"Pouclet","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"2017010917501004000_nlw103v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.04.020"},{"key":"2017010917501004000_nlw103v1.22","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1214-6"},{"key":"2017010917501004000_nlw103v1.23","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25298"},{"key":"2017010917501004000_nlw103v1.24","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25776"},{"key":"2017010917501004000_nlw103v1.25","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1007\/s00415-014-7529-y","article-title":"Antemortem detection of colonic \u03b1-synuclein pathology in a patient with pure autonomic failure","volume":"261","author":"Masuda","year":"2014","journal-title":"J Neurol"},{"key":"2017010917501004000_nlw103v1.26","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001240"},{"key":"2017010917501004000_nlw103v1.27","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25789"},{"key":"2017010917501004000_nlw103v1.28","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1040-2"},{"key":"2017010917501004000_nlw103v1.29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/ene.12753","article-title":"Can we use peripheral tissue biopsies to diagnose Parkinson\u2019s disease? A review of the literature","volume":"23","author":"Schneider","year":"2016","journal-title":"Eur J Neurol"},{"key":"2017010917501004000_nlw103v1.30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/mds.26473","article-title":"\u03b1-synuclein in gastric and colonic mucosa in Parkinson\u2019s disease: Limited role as a biomarker","volume":"31","author":"Chung","year":"2016","journal-title":"Mov Disord"},{"key":"2017010917501004000_nlw103v1.31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/JAD-2006-9309","article-title":"Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders","volume":"9","author":"Abdi","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"2017010917501004000_nlw103v1.32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1212\/WNL.0000000000001904","article-title":"Colonic mucosal \u03b1-synuclein lacks specificity as a biomarker for Parkinson disease","volume":"85","author":"Woulfe","year":"2015","journal-title":"Neurology"},{"key":"2017010917501004000_nlw103v1.33","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1212\/WNL.0000000000002130","article-title":"Does REM sleep behavior disorder have the guts to be Parkinson disease?","volume":"85","author":"Unger","year":"2015","journal-title":"Neurology"},{"key":"2017010917501004000_nlw103v1.34","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1212\/WNL.0000000000002126","article-title":"Enteric nervous system \u03b1-synuclein immunoreactivity in idiopathic REM sleep behavior disorder","volume":"85","author":"Sprenger","year":"2015","journal-title":"Neurology"},{"key":"2017010917501004000_nlw103v1.35","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.3892\/mmr.2016.5166","article-title":"Post-translational modifications of \u03b1-synuclein contribute to neurodegeneration in the colon of elderly individuals","volume":"13","author":"Xuan","year":"2016","journal-title":"Mol Med Rep"},{"key":"2017010917501004000_nlw103v1.36","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12247"},{"key":"2017010917501004000_nlw103v1.37","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/mds.25779","article-title":"\u03b1-synuclein in the appendiceal mucosa of neurologically intact subjects","volume":"29","author":"Gray","year":"2014","journal-title":"Mov Disord"},{"key":"2017010917501004000_nlw103v1.38","first-page":"167038","article-title":"Clinical utility of skin biopsy in differentiating between Parkinson\u2019s disease and multiple system atrophy","volume":"2015","author":"Haga","year":"2015","journal-title":"Parkinsons Dis"},{"key":"2017010917501004000_nlw103v1.39","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.24567","article-title":"Skin nerve misfolded \u03b1-synuclein in pure autonomic failure and Parkinson disease","volume":"79","author":"Donadio","year":"2016","journal-title":"Ann Neurol"},{"key":"2017010917501004000_nlw103v1.40","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000316"},{"key":"2017010917501004000_nlw103v1.41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.autneu.2016.05.004","article-title":"Skin biopsy and microneurography disclose selective noradrenergic dysfunction due to dopamine-beta-hydroxylase deficiency","volume":"197","author":"Donadio","year":"2016","journal-title":"Auton Neurosci"},{"key":"2017010917501004000_nlw103v1.42","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1284-0"},{"key":"2017010917501004000_nlw103v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.02.030"},{"key":"2017010917501004000_nlw103v1.44","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cff6d5"},{"key":"2017010917501004000_nlw103v1.45","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318186de48"},{"key":"2017010917501004000_nlw103v1.46","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00702-014-1355-3","article-title":"Cutaneous autonomic denervation in Parkinson\u2019s disease","volume":"122","author":"Navarro-Otano","year":"2015","journal-title":"J Neural Transm"},{"key":"2017010917501004000_nlw103v1.47","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv138"},{"key":"2017010917501004000_nlw103v1.48","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/mds.25988","article-title":"In vivo gastric detection of \u03b1-synuclein inclusions in Parkinson\u2019s disease","volume":"30","author":"Sanchez-Ferro","year":"2015","journal-title":"Mov Disord"},{"key":"2017010917501004000_nlw103v1.49","first-page":"1714","article-title":"\u03b1-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease","volume":"7","author":"Ito","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"2017010917501004000_nlw103v1.50","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0664-3"},{"key":"2017010917501004000_nlw103v1.51","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3233\/JPD-150680","article-title":"Prevalence of submandibular gland synucleinopathy in Parkinson\u2019s disease, dementia with Lewy bodies and other Lewy body disorders","volume":"6","author":"Beach","year":"2016","journal-title":"J Parkinsons Dis"},{"key":"2017010917501004000_nlw103v1.52","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318258381b"},{"key":"2017010917501004000_nlw103v1.53","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182965886"},{"key":"2017010917501004000_nlw103v1.54","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182801cde"},{"key":"2017010917501004000_nlw103v1.55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00455-015-9612-7","article-title":"\u03b1-synuclein pathology in sensory nerve terminals of the upper aerodigestive tract of parkinson\u2019s disease patients","volume":"30","author":"Mu","year":"2015","journal-title":"Dysphagia"},{"key":"2017010917501004000_nlw103v1.56","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0665-2"},{"key":"2017010917501004000_nlw103v1.57","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182805c72"},{"key":"2017010917501004000_nlw103v1.58","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000204"},{"key":"2017010917501004000_nlw103v1.59","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/mds.26476","article-title":"Peripheral synucleinopathy in early Parkinson\u2019s disease: Submandibular gland needle biopsy findings","volume":"31","author":"Adler","year":"2016","journal-title":"Mov Disord"},{"key":"2017010917501004000_nlw103v1.60","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23344"},{"key":"2017010917501004000_nlw103v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.07.016"},{"key":"2017010917501004000_nlw103v1.62","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000641"},{"key":"2017010917501004000_nlw103v1.63","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(87)80001-8"},{"key":"2017010917501004000_nlw103v1.64","first-page":"233","article-title":"The mandate for a proper preservation in histopathological tissues","volume":"53","author":"Comanescu","year":"2012","journal-title":"Rom J Morphol Embryol"},{"key":"2017010917501004000_nlw103v1.65","doi-asserted-by":"publisher","DOI":"10.3109\/10520299609117164"},{"key":"2017010917501004000_nlw103v1.66","doi-asserted-by":"publisher","DOI":"10.3109\/00313028909061071"},{"key":"2017010917501004000_nlw103v1.67","doi-asserted-by":"publisher","DOI":"10.1177\/41.3.8429209"},{"key":"2017010917501004000_nlw103v1.68","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0409-8"},{"key":"2017010917501004000_nlw103v1.69","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/10520290903039052","article-title":"Special symposium: Fixation and tissue processing models","volume":"84","author":"Grizzle","year":"2009","journal-title":"Biotech Histochem"},{"key":"2017010917501004000_nlw103v1.70","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000264429.59379.d9"},{"key":"2017010917501004000_nlw103v1.71","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nbd.2012.07.018","article-title":"Expression pattern and localization of \u03b1-synuclein in the human enteric nervous system","volume":"48","author":"Bottner","year":"2012","journal-title":"Neurobiol Dis"},{"key":"2017010917501004000_nlw103v1.72","doi-asserted-by":"crossref","unstructured":"Schulz-Schaeffer WJ Fatzer R Vandevelde M , . Detection of PrP(Sc) in subclinical BSE with the paraffin-embedded tissue (PET) blot. Arch Virol Suppl 2000;173\u201380","DOI":"10.1007\/978-3-7091-6308-5_16"},{"key":"2017010917501004000_nlw103v1.73","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31829d2799"},{"key":"2017010917501004000_nlw103v1.74","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3233\/JPD-150670","article-title":"Optimizing Western blots for the detection of endogenous \u03b1-synuclein in the enteric nervous system","volume":"5","author":"Preterre","year":"2015","journal-title":"J Parkinsons Dis"},{"key":"2017010917501004000_nlw103v1.75","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a9f449"},{"key":"2017010917501004000_nlw103v1.76","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1212\/WNL.0000000000002919","article-title":"The diagnostic discrimination of cutaneous \u03b1-synuclein deposition in Parkinson disease","volume":"87","author":"Gibbons","year":"2016","journal-title":"Neurology"},{"key":"2017010917501004000_nlw103v1.77","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/mds.26189","article-title":"Skin biopsy and I-123 MIBG scintigraphy findings in idiopathic Parkinson\u2019s disease and parkinsonism: A comparative study","volume":"30","author":"Giannoccaro","year":"2015","journal-title":"Mov Disord"},{"key":"2017010917501004000_nlw103v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.12.027"},{"key":"2017010917501004000_nlw103v1.79","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S1474-4422(16)00080-6","article-title":"Assessment of \u03b1-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: A case-control study","volume":"15","author":"Vilas","year":"2016","journal-title":"Lancet Neurol"},{"key":"2017010917501004000_nlw103v1.80","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40478-016-0305-8","article-title":"Evaluation of \u03b1-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies","volume":"4","author":"Corbille","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"2017010917501004000_nlw103v1.81","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3233\/JPD-160888","article-title":"Multicenter assessment of immuno-histochemical methods for pathological \u03b1-synuclein in sigmoid colon of autopsied Parkinson\u2019s disease and control subjects","volume":"6","author":"Beach","year":"2016","journal-title":"J Parkinsons Dis"},{"key":"2017010917501004000_nlw103v1.82","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12189"},{"key":"2017010917501004000_nlw103v1.83","doi-asserted-by":"publisher","DOI":"10.1369\/0022155410396931"},{"key":"2017010917501004000_nlw103v1.84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600933200"},{"key":"2017010917501004000_nlw103v1.85","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5314-13.2014"},{"key":"2017010917501004000_nlw103v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.11.018"},{"key":"2017010917501004000_nlw103v1.87","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm302"},{"key":"2017010917501004000_nlw103v1.88","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-310686"},{"key":"2017010917501004000_nlw103v1.89","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26000"},{"key":"2017010917501004000_nlw103v1.90","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.arr.2016.01.001","article-title":"(123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in \u03b1-synucleinopathies","volume":"30","author":"Orimo","year":"2016","journal-title":"Ageing Res Rev"},{"key":"2017010917501004000_nlw103v1.91","doi-asserted-by":"crossref","first-page":"e0152746","DOI":"10.1371\/journal.pone.0152746","article-title":"On the utility of MIBG SPECT\/CT in evaluating cardiac sympathetic dysfunction in Lewy body diseases","volume":"11","author":"Odagiri","year":"2016","journal-title":"PLoS One"},{"key":"2017010917501004000_nlw103v1.92","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7135-4"},{"key":"2017010917501004000_nlw103v1.93","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12437"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T18:02:23Z","timestamp":1718992943000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/nlw103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,9]]},"references-count":93,"alternative-id":["10.1093\/jnen\/nlw103"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlw103","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,9]]}}}