{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:18:43Z","timestamp":1793992723774,"version":"4.8.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"DOI":"10.1093\/jnen\/nlw105","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T20:50:13Z","timestamp":1483995013000},"page":"nlw105","source":"Crossref","is-referenced-by-count":15,"title":["A Quantitative Analysis of Brain Soluble Tau and the Tau Secretion Factor"],"prefix":"10.1093","author":[{"given":"Pengcheng","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geidy","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Beach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Caselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"2017010917500999000_nlw105v1.1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1042\/BST0380962","article-title":"Alzheimer\u2019s disease neurofibrillary degeneration: pivotal and multifactorial","volume":"38","author":"Iqbal","year":"2010","journal-title":"Biochemical Soc Trans"},{"key":"2017010917500999000_nlw105v1.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0486-3"},{"key":"2017010917500999000_nlw105v1.3","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00083"},{"key":"2017010917500999000_nlw105v1.4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fneur.2015.00038","article-title":"PET Imaging of tau pathology in Alzheimer\u2019s disease and tauopathies","volume":"6","author":"James","year":"2015","journal-title":"Front Neurol"},{"key":"2017010917500999000_nlw105v1.5","doi-asserted-by":"crossref","first-page":"e0140311","DOI":"10.1371\/journal.pone.0140311","article-title":"Longitudinal assessment of tau pathology in patients with Alzheimer\u2019s Disease using [18F]THK-5117 positron emission tomography","volume":"10","author":"Ishiki","year":"2015","journal-title":"PloS One"},{"key":"2017010917500999000_nlw105v1.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815140"},{"key":"2017010917500999000_nlw105v1.7","first-page":"565","article-title":"Biochemical and anatomical redistribution of tau protein in Alzheimer's disease","volume":"143","author":"Mukaetova-Ladinska","year":"1993","journal-title":"Am J Pathol"},{"key":"2017010917500999000_nlw105v1.8","first-page":"95","article-title":"Alterations in tau protein metabolism during normal aging","volume":"7","author":"Mukaetova-Ladinska","year":"1996","journal-title":"Dementia"},{"key":"2017010917500999000_nlw105v1.9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-2011-110161","article-title":"Tau transgenic mice as models for cerebrospinal fluid tau biomarkers","volume":"24(Suppl 2)","author":"Barten","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"2017010917500999000_nlw105v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/nn0905-1136"},{"key":"2017010917500999000_nlw105v1.11","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-1-6"},{"key":"2017010917500999000_nlw105v1.12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/NEN.0000000000000157","article-title":"Tau proteins in the temporal and frontal cortices in patients with vascular dementia","volume":"74","author":"Mukaetova-Ladinska","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"2017010917500999000_nlw105v1.13","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199710000-00002"},{"key":"2017010917500999000_nlw105v1.14","doi-asserted-by":"publisher","DOI":"10.2174\/156720509788929237"},{"key":"2017010917500999000_nlw105v1.15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181af79fb"},{"key":"2017010917500999000_nlw105v1.16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181af79e5"},{"key":"2017010917500999000_nlw105v1.17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/jamaneurol.2014.3625","article-title":"Association of pituitary adenylate cyclase-activating polypeptide with cognitive decline in mild cognitive impairment due to Alzheimer disease","volume":"72","author":"Han","year":"2015","journal-title":"JAMA Neurol"},{"key":"2017010917500999000_nlw105v1.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1991.tb00661.x"},{"key":"2017010917500999000_nlw105v1.19","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"2017010917500999000_nlw105v1.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2017010917500999000_nlw105v1.21","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31821300bc"},{"key":"2017010917500999000_nlw105v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70142-4"},{"key":"2017010917500999000_nlw105v1.23","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12189"},{"key":"2017010917500999000_nlw105v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.02.011"},{"key":"2017010917500999000_nlw105v1.25","unstructured":"Karcher DS McPherson RA , Cerebral, synovial, serous body fluids, and alternative specimens. In: MacPherson RA , eds. Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods , 23rd ed. St.Louis, MO: Elsevier, Inc. 2017:481\u2013508"},{"key":"2017010917500999000_nlw105v1.26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1001\/jamaneurol.2015.0202","article-title":"Cerebrospinal fluid markers of neurodegeneration and rates of brain atrophy in early Alzheimer disease","volume":"72","author":"Tarawneh","year":"2015","journal-title":"JAMA Neurol"},{"key":"2017010917500999000_nlw105v1.27","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.bbadis.2015.04.015","article-title":"Sequence-dependent abnormal aggregation of human Tau fragment in an inducible cell model","volume":"1852","author":"Liu","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2017010917500999000_nlw105v1.28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.616029"},{"key":"2017010917500999000_nlw105v1.29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01879.x"},{"key":"2017010917500999000_nlw105v1.30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1001\/jamaneurol.2015.1285","article-title":"Longitudinal cerebrospinal fluid biomarker changes in preclinical Alzheimer disease during middle age","volume":"72","author":"Sutphen","year":"2015","journal-title":"JAMA Neurol"},{"key":"2017010917500999000_nlw105v1.31","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv199"},{"key":"2017010917500999000_nlw105v1.32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s12035-013-8544-1","article-title":"Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics","volume":"49","author":"Kalani","year":"2014","journal-title":"Molec Neurobiol"},{"key":"2017010917500999000_nlw105v1.33","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.neurobiolaging.2014.05.019","article-title":"Cerebrospinal fluid sphingolipids, \u03b2-amyloid, and tau in adults at risk for Alzheimer\u2019s disease","volume":"35","author":"Mielke","year":"2014","journal-title":"Neurobiol Aging"},{"key":"2017010917500999000_nlw105v1.34","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2353"},{"key":"2017010917500999000_nlw105v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.03.022"}],"container-title":["Journal of Neuropathology & Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T05:52:17Z","timestamp":1568699537000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/nlw105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,9]]},"references-count":35,"alternative-id":["10.1093\/jnen\/nlw105"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlw105","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,9]]}}}