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We investigated relationships between antemortem global cognitive scores and \u03b2-amyloid (A\u03b2), tau, TDP-43, synaptic proteins and other key AD neuropathological markers assessed by biochemical approaches in postmortem anterior parietal cortex samples from 36 subjects (12\u2009MCI, 12 AD and 12 not cognitively impaired) from the Religious Orders Study. Overall, the strongest negative correlation coefficients associated with global cognitive scores were obtained for insoluble phosphorylated tau (r2\u2009=\u2009\u22120.484), insoluble A\u03b242 (r2\u2009=\u2009\u22120.389) and neurofibrillary tangle counts (r2\u2009=\u2009\u22120.494) (all p\u2009&amp;lt;\u20090.001). Robust inverse associations with cognition scores were also established for TDP-43-positive cytoplasmic inclusions (r2\u2009=\u2009\u22120.476), total insoluble tau (r2\u2009=\u2009\u22120.385) and A\u03b2 plaque counts (r2\u2009=\u2009\u22120.426). Sarkosyl (SK)- or formic acid (FA)-extracted tau showed similar interrelations. On the other hand, synaptophysin (r2\u2009=\u2009+0.335), pS403\/404 TDP-43 (r2\u2009=\u2009+0.265) and septin-3 (r2\u2009=\u2009+0.257) proteins positively correlated with cognitive scores. This study suggests that tau and A\u03b242 in their insoluble aggregated forms, synaptic proteins and TDP-43 are the markers in the parietal cortex that are most strongly associated with cognitive function. This further substantiates the relevance of investigating these markers to understand the pathogenesis of AD and develop therapeutic tools.<\/jats:p>","DOI":"10.1093\/jnen\/nlw109","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T22:43:08Z","timestamp":1486161788000},"page":"70-88","source":"Crossref","is-referenced-by-count":49,"title":["Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease"],"prefix":"10.1093","volume":"76","author":[{"given":"Cyntia","family":"Tremblay","sequence":"first","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec (CHU-Q) Research Center, Neuroscience Axis, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec (CHU-Q) Research Center, Neuroscience Axis, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Delay","sequence":"additional","affiliation":[{"name":"Facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement (RID-AGE) Research Group, University of Lille, INSERM U1167, Lille University Medical Center, Institut Pasteur de Lille, Lille, France (CD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Freland","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec (CHU-Q) Research Center, Neuroscience Axis, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mil\u00e8ne","family":"Vandal","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec (CHU-Q) Research Center, Neuroscience Axis, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Calon","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec (CHU-Q) Research Center, Neuroscience Axis, Qu\u00e9bec, QC, 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